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RPS6KA2 Antibody

  • 中文名稱:
    RPS6KA2兔多克隆抗體
  • 貨號:
    CSB-PA618003LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA618003LA01HU at dilution of 1:100
    • Immunofluorescence staining of Hela cells with CSB-PA618003LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RPS6KA2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    90 kDa ribosomal protein S6 kinase 2 antibody; HU 2 antibody; KS6A2_HUMAN antibody; MAP kinase activated protein kinase 1c antibody; MAP kinase-activated protein kinase 1c antibody; MAPK-activated protein kinase 1c antibody; MAPKAP kinase 1c antibody; MAPKAPK-1c antibody; MAPKAPK1C antibody; Mitogen.activated protein kinase-activated protein kinase 1C antibody; p90 RSK3 antibody; p90-RSK 2 antibody; p90RSK2 antibody; pp90RSK3 antibody; Ribosomal protein S6 kinase alpha-2 antibody; ribosomal protein S6 kinase; 90kDa; polypeptide 2 antibody; Ribosomal S6 kinase 3 antibody; RPS6KA2 antibody; RSK 3 antibody; RSK antibody; RSK-3 antibody; S6K alpha antibody; S6K alpha 2 antibody; S6K-alpha-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ribosomal protein S6 kinase alpha-2 protein (228-395AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,RPS6KA2 Antibody (CSB-PA618003LA01HU),的標記方式是Non-conjugated。對于RPS6KA2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA618003LB01HU RPS6KA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA618003LC01HU RPS6KA2 Antibody, FITC conjugated
    Biotin CSB-PA618003LD01HU RPS6KA2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
  • 基因功能參考文獻:
    1. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
    2. Data indicate that S6 kinase 2 (S6K2) can phosphorylate histone H3 at position Thr45, which may play a role during cell proliferation and/or differentiation. PMID: 23564320
    3. Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis. PMID: 24403857
    4. genetic association study in Han population in China: Data suggest that SNPs in RSK3 (rs2229712) and in MEK1 (rs28730804) demonstrate gene-gene interaction that affects antidepressant drug outcome in female patients with major depressive disorder. PMID: 23727904
    5. Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. PMID: 23635776
    6. p90RSK2 is dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-internal tandem duplication-induced hematopoietic transformation. PMID: 21527514
    7. Characterization of the terminal domain as a protein kinase PMID: 12016217
    8. chronic activation CREB and p90RSK in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis PMID: 14646589
    9. The accumulation of S6K2 in the nuclei of cancer cells and the correlation with the expression of PCNA and Ki-67 suggest the involvement of S6K2 in the regulation of malignant growth PMID: 15995633
    10. p90Rsk-mediated modulation of Hdm2 nuclear is linked to cytoplasmic shuttling with the diminished ability of p53 to regulate cell cycle checkpoints that ultimately leads to transformation PMID: 16621805
    11. The above results suggest that RPS6KA2 is a putative tumour suppressor gene to explain allele loss at 6q27. PMID: 16878154
    12. there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17 PMID: 16895915

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  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 組織特異性:
    Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
  • 數據庫鏈接:

    HGNC: 10431

    OMIM: 601685

    KEGG: hsa:6196

    STRING: 9606.ENSP00000427015

    UniGene: Hs.655277



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