在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RPS6KA2 Antibody

RPS6KA2 Antibody

  • 中文名稱：
    RPS6KA2兔多克隆抗體
  • 貨號：
    CSB-PA618003LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA618003LA01HU at dilution of 1:100
    • Immunofluorescence staining of Hela cells with CSB-PA618003LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RPS6KA2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    90 kDa ribosomal protein S6 kinase 2 antibody; HU 2 antibody; KS6A2_HUMAN antibody; MAP kinase activated protein kinase 1c antibody; MAP kinase-activated protein kinase 1c antibody; MAPK-activated protein kinase 1c antibody; MAPKAP kinase 1c antibody; MAPKAPK-1c antibody; MAPKAPK1C antibody; Mitogen.activated protein kinase-activated protein kinase 1C antibody; p90 RSK3 antibody; p90-RSK 2 antibody; p90RSK2 antibody; pp90RSK3 antibody; Ribosomal protein S6 kinase alpha-2 antibody; ribosomal protein S6 kinase; 90kDa; polypeptide 2 antibody; Ribosomal S6 kinase 3 antibody; RPS6KA2 antibody; RSK 3 antibody; RSK antibody; RSK-3 antibody; S6K alpha antibody; S6K alpha 2 antibody; S6K-alpha-2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ribosomal protein S6 kinase alpha-2 protein (228-395AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RPS6KA2 Antibody (CSB-PA618003LA01HU)，的標記方式是Non-conjugated。對于RPS6KA2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA618003LB01HU RPS6KA2 Antibody, HRP conjugated ELISA
    FITC CSB-PA618003LC01HU RPS6KA2 Antibody, FITC conjugated
    Biotin CSB-PA618003LD01HU RPS6KA2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
  • 基因功能參考文獻：
    1. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
    2. Data indicate that S6 kinase 2 (S6K2) can phosphorylate histone H3 at position Thr45, which may play a role during cell proliferation and/or differentiation. PMID: 23564320
    3. Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis. PMID: 24403857
    4. genetic association study in Han population in China: Data suggest that SNPs in RSK3 (rs2229712) and in MEK1 (rs28730804) demonstrate gene-gene interaction that affects antidepressant drug outcome in female patients with major depressive disorder. PMID: 23727904
    5. Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. PMID: 23635776
    6. p90RSK2 is dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-internal tandem duplication-induced hematopoietic transformation. PMID: 21527514
    7. Characterization of the terminal domain as a protein kinase PMID: 12016217
    8. chronic activation CREB and p90RSK in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis PMID: 14646589
    9. The accumulation of S6K2 in the nuclei of cancer cells and the correlation with the expression of PCNA and Ki-67 suggest the involvement of S6K2 in the regulation of malignant growth PMID: 15995633
    10. p90Rsk-mediated modulation of Hdm2 nuclear is linked to cytoplasmic shuttling with the diminished ability of p53 to regulate cell cycle checkpoints that ultimately leads to transformation PMID: 16621805
    11. The above results suggest that RPS6KA2 is a putative tumour suppressor gene to explain allele loss at 6q27. PMID: 16878154
    12. there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17 PMID: 16895915

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 組織特異性：
    Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
  • 數據庫鏈接：

    HGNC: 10431

    OMIM: 601685

    KEGG: hsa:6196

    STRING: 9606.ENSP00000427015

    UniGene: Hs.655277



主站蜘蛛池模板： 亚洲午夜福利院在线观看| 亚洲一区天堂九一| 欧美日韩视频在线第一区 | 成在人线av无码免费漫画| 人妻aⅴ中文字幕无码| 欧美多毛肥胖老妇做爰| 无码国产精成人午夜视频一区二区| 国内精品九九久久久精品| 日本少妇人妻xxxxx18| 欧洲av无码放荡人妇网站| 髙清国产性猛交xxxand| 亚洲337少妇裸体艺术| 国产精品无码久久综合网| 久久精品无码一区二区三区免费| 成人性做爰片免费视频| 国产98色在线 | 国| 国产在线看片无码人精品| 亚洲午夜成人av电影| 亚洲日韩中文无码久久| 乱人伦无码中文视频在线| 精品少妇无码一区二区三批| 少妇人妻av无码专区| 放荡的美妇在线播放| 狠狠色噜噜狠狠狠7777米奇| 精品欧美成人高清在线观看| 久久天天躁夜夜躁狠狠85麻豆 | 午夜在线a亚洲v天堂网2018| 青青草国产免费国产是公开| 50岁熟妇大白屁股真爽| 国产精品成人国产乱| 热99re久久精品国产首页免费| 亚洲乱码在线卡一卡二卡新区 | 噜噜色综合噜噜色噜噜色| 最新69国产成人精品视频| 日韩乱码人妻无码中文视频| 深夜福利在线观看视频 | 欧美黑人巨大videos精品男男 | 国产日韩精品一区二区三区在线| 免费无码又爽又刺激一高潮| 免费精品国产自在| 69精品人人人人|