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RPRD1A Antibody

  • 中文名稱：
    RPRD1A兔多克隆抗體
  • 貨號：
    CSB-PA850404LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: RPRD1A antibody at 2μg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to Rabbit IgG at 1/10000 dilution
      Predicted band size: 36, 32 kDa
      Observed band size: 36 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RPRD1A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RPRD1A
  • 別名：
    C77387 antibody; CDKN2B-related protein antibody; Cyclin dependent kinase 2B inhibitor related protein antibody; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein) antibody; Cyclin dependent kinase inhibitor 2B related protein antibody; Cyclin dependent kinase inhibitor related protein antibody; Cyclin-dependent kinase inhibitor 2B-related protein antibody; FLJ10656 antibody; HsT3101 antibody; Hypothetical protein FLJ10656 antibody; KIAA4077 antibody; MGC19513 antibody; MGC29396 antibody; MGC36325 antibody; mKIAA4077 antibody; p15INK4B related protein antibody; p15INK4B-related protein antibody; Putative uncharacterized protein P15RS antibody; Regulation of nuclear pre mRNA domain containing 1A antibody; Regulation of nuclear pre-mRNA domain-containing protein 1A antibody; RGD1307374 antibody; RPR1A_HUMAN antibody; RPRD1A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A protein (2-276AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RPRD1A Antibody (CSB-PA850404LA01HU)，的標記方式是Non-conjugated。對于RPRD1A Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA850404LB01HU RPRD1A Antibody, HRP conjugated ELISA
    FITC CSB-PA850404LC01HU RPRD1A Antibody, FITC conjugated
    Biotin CSB-PA850404LD01HU RPRD1A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
  • 基因功能參考文獻：
    1. Data suggest that p15RS (p15INK4b-related sequence) acts as an intrinsic transcriptional repressor for Wnt/beta-catenin-mediated gene transcription through recruiting HDAC2 histone deacetylase. PMID: 25697359
    2. RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2. PMID: 24997600
    3. The p15RS expression specifically downregulates the expression of cathepsin B and MMP-9 at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins. PMID: 22580456
    4. p15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters. PMID: 20739273
    5. molecular cloning and characterization of P15RS, a novel P15(INK4b) related gene involved in G1/S progression PMID: 12470661

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  • 蛋白家族：
    UPF0400 (RTT103) family
  • 數據庫鏈接：

    HGNC: 25560

    OMIM: 610347

    KEGG: hsa:55197

    STRING: 9606.ENSP00000349955

    UniGene: Hs.464912



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