在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RPL5 Antibody

RPL5 Antibody

  • 中文名稱：
    RPL5兔多克隆抗體
  • 貨號(hào)：
    CSB-PA020297GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RPL5
  • 別名：
    60S ribosomal protein L5 antibody; DBA6 antibody; L5 antibody; MSTP030 antibody; PPP1R135 antibody; protein phosphatase 1, regulatory subunit 135 antibody; Ribosomal protein L5 antibody; RL5 antibody; RL5_HUMAN antibody; RP L5 antibody; RPL 5 antibody; RPL5 antibody; U21 RNA antibody; U21RNA antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human RPL5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.
  • 基因功能參考文獻(xiàn)：
    1. RPL5 remains an interesting candidate in multiple myelom(MM )because it is deleted in 20-40% of MM cases PMID: 28428269
    2. Whole exome sequencing in the differential diagnosis of Diamond-Blackfan anemia: Clinical and molecular study of three patients with novel RPL5 and mosaic RPS19 mutations PMID: 28376382
    3. Low RPL5 expression is associated with cancer. PMID: 28147343
    4. Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition. PMID: 25301064
    5. RPL5 mutation is associated with Diamond Blackfan Anemia. PMID: 25132370
    6. Findings uncover a mechanism by which RPL5 and RPL11 can co-operatively suppress c-Myc expression, allowing a tightly controlled ribosome biogenesis in cells. PMID: 24141778
    7. Unlike other tumor suppressors, RPL5 and RPL11 play essential roles in normal cell proliferation. PMID: 24061479
    8. High frequency of RPL5 gene deletion is associated with Italian Diamond-Blackfan anemia. PMID: 22689679
    9. Oncogenic splicing factor SRSF1 stabilizes the tumor suppressor protein p53 via RPL5, inducing cell senescence. PMID: 23478443
    10. Mutations affect the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias. PMID: 23263491
    11. disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stress PMID: 23169665
    12. Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A deletion, 3 with RPS17 deletions, and 1 with an RPS19 deletion. PMID: 22262766
    13. Data show that all patients with RPS19 and RPL5 mutations had physical abnormalities. PMID: 20378560
    14. An analysis and fine mapping of GFI-EVI5-RPL5-FAM69A locus, genotyping eight Tag-single nucleotide polymorphisms in 732 multiple sclerosis patients and 974 controls from Spain, was performed. PMID: 20087403
    15. Knockdown of L29 or L30 enhanced the interaction of MDM2 with L11 and L5 and markedly inhibited MDM2-mediated p53 ubiquitination, suggesting that direct perturbation of 60 S ribosomal biogenesis activates p53 via L11- and L5-mediated MDM2 suppression. PMID: 20554519
    16. The study reports a high frequency of RPL5 (9.3%) and RPL11 (9.3%) mutations in a Diamond-Blackfan anemia cohort. PMID: 19773262
    17. the presence of multiple NLSs in ribosomal protein L5 appears to allow for efficient nuclear transport via utilisation of multiple, mechanistically different import pathways. PMID: 11824785
    18. the MDM2-L5-L11-L23 complex functions to inhibit MDM2-mediated p53 ubiquitination and thus activates p53 PMID: 15308643
    19. interaction of NVL2 with L5 is ATP-dependent and likely contributes to the nucleolar translocation of NVL2 PMID: 15469983
    20. Cancer-associated missense mutations targeting MDM2's central zinc finger disrupt the interaction of MDM2 with L5 and L11. PMID: 17116689
    21. 5-FU treatment triggers a ribosomal stress response so that ribosomal proteins L5, L11, and L23 are released from ribosome to activate p53 by ablating the MDM2-p53 feedback circuit PMID: 17242401
    22. L11 cooperates with L5, resulting in a robust inhibition of the E3 activity of MDM2, and a stabilization and activation of p53 approaching that achieved by p14(ARF). PMID: 18560357
    23. Susceptibility gene for multiple sclerosis in Australians. PMID: 18650830
    24. RPL5 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. PMID: 19061985
    25. Mutations in RPL5 were identified in eight patients from 6 out of 28 families (21.4%). PMID: 19191325

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Diamond-Blackfan anemia 6 (DBA6)
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus, nucleolus.
  • 蛋白家族：
    Universal ribosomal protein uL18 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10360

    OMIM: 603634

    KEGG: hsa:6125

    STRING: 9606.ENSP00000359345

    UniGene: Hs.532359



主站蜘蛛池模板： 欧美一区二区日韩国产| 99精品无人区乱码1区2区3区| 性欧美大战久久久久久久| 欧美freesex黑人又粗又大| 亚洲国产制服丝袜无码av| a毛片免费全部播放自慰| 国产成人精品无码a区在线观看| 少妇系列之白嫩人妻| 成人区精品一区二区婷婷| 日本人妻中文字幕乱码系列| 国产成人精品午夜福利不卡| 国产成人a视频高清在线观看| 快好爽射给我视频| 手机看黄av免费网址| 老子影院午夜伦手机不四虎卡| 青青草97国产精品免费观看| 日本五月天婷久久网站| 国产高清视频色拍| 亚洲日韩一区二区| 欧美一区二区| 青青草国产免费久久久| 欧美人与动牲交zooz| 无码中文字幕日韩专区视频| 国产麻豆乱子伦午夜视频观看| 综合色区国产亚洲另类| 成人精品天堂一区二区三区| 国产成人一区二区三区别| 奇米777国产在线视频| 亚洲国产成人一区二区三区| 久久久www成人免费无遮挡大片 | 日本阿v网站在线观看中文| 业余 自由 性别 成熟视频 视频 | 国产亚洲人成无码网在线观看| 男女下面进入的视频免费午夜 | 亚洲偷自拍国综合色帝国| 中文字幕av无码免费一区| 国产精品午夜无码av天美传媒| 无码av天天av天天爽| 久久99精品久久久久久2021| 亚洲人成色777777老人头| 极品嫩模高潮叫床|