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  4. RPL26 Antibody

RPL26 Antibody

  • 中文名稱：
    RPL26兔多克隆抗體
  • 貨號：
    CSB-PA020207LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA020207LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • IHC image of CSB-PA020207LA01HU diluted at 1:600 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RPL26 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RPL26
  • 別名：
    tibody; 60S ribosomal protein L26 antibody; 60S ribosomal protein L26 like 1 antibody; DBA11 antibody; FLJ46904 antibody; L26 antibody; OTTHUMP00000135333 antibody; PTB associated splicing factor antibody; Ribosomal protein L26 antibody; Ribosomal protein L26 homolog antibody; Ribosomal protein L26 like 1 antibody; Ribosomal protein L26 pseudogene 1 antibody; RL26_HUMAN antibody; rpl26 antibody; RPL26P1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human 60S ribosomal protein L26 protein (48-143AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，RPL26 Antibody (CSB-PA020207LA01HU)，的標(biāo)記方式是Non-conjugated。對于RPL26 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA020207LB01HU RPL26 Antibody, HRP conjugated ELISA
    FITC CSB-PA020207LC01HU RPL26 Antibody, FITC conjugated
    Biotin CSB-PA020207LD01HU RPL26 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the large ribosomal subunit.
  • 基因功能參考文獻：
    1. ionizing radiation (IR) inhibits the activity of SMG1, a phosphoinositide-3-kinase-like kinase family member, reducing the binding of SMG1 to a specific region near exon 9 of p53 precursor mRNA and promoting the binding of ribosomal protein L26 (RPL26) to p53 pre-mRNA PMID: 28288992
    2. In colorectal tumor cells RPL26 regulates p73 expression via two distinct mechanisms: protein stability and mRNA translation. PMID: 27825141
    3. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
    4. The results showed that knockdown of RPL26 or RPL29 expression significantly suppressed cell proliferation, induced cell arrest at G0/G1 phase and enhanced cell apoptosis PMID: 22868929
    5. Northern Blot Together with RPL5, RPL11, and RPS7, RPL26 is the fourth RP regulating p53 activity that is linked to diamond-blackfan anemia. PMID: 22431104
    6. suggest a model in which the base pairings in the p53 UTR interaction regions are critical for both translational repression and stress induction of p53 by NCL and RPL26 PMID: 22433872
    7. Mdm2 binds L26 and drives its polyubiquitylation and proteasomal degradation. PMID: 18951086

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  • 相關(guān)疾病：
    Diamond-Blackfan anemia 11 (DBA11)
  • 蛋白家族：
    Universal ribosomal protein uL24 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10327

    OMIM: 603704

    KEGG: hsa:6154

    STRING: 9606.ENSP00000293842

    UniGene: Hs.482144



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