在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RPA3 Antibody

  • 中文名稱:
    RPA3兔多克隆抗體
  • 貨號:
    CSB-PA16239A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA16239A0Rb at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RPA3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    p14 antibody; REPA 3 antibody; REPA3 antibody; Replication factor A protein 3 antibody; Replication protein A 14 kDa subunit antibody; Replication protein A3 14kD antibody; Replication protein A3 14kDa antibody; Replication protein A3 antibody; RF A antibody; RF A protein 3 antibody; RF-A protein 3 antibody; RFA protein 3 antibody; RFA3_HUMAN antibody; RP A antibody; RP A p14 antibody; RP-A p14 antibody; RPA 14 antibody; RPA 3 antibody; RPA p14 antibody; rpa3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Replication protein A 14 kDa subunit protein (1-119AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,RPA3 Antibody (CSB-PA16239A0Rb),的標記方式是Non-conjugated。對于RPA3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA16239B0Rb RPA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA16239C0Rb RPA3 Antibody, FITC conjugated
    Biotin CSB-PA16239D0Rb RPA3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER), probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA. As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
  • 基因功能參考文獻:
    1. RPA3 is a potential marker of prognosis, radioresistance and survival in nasopharyngeal carcinoma. PMID: 28557284
    2. Elevated expression of RPA3 promotes tumor progression in hepatocellular carcinoma cells. PMID: 28683444
    3. Up-regulation of RPA3 is involved in gastric cancer tumorigenesis and is associated with poorer patient survival. PMID: 28766245
    4. The allele "T" of rs6947203 in the RPA3 gene acts as a protective allele in glioma. PMID: 23573956
    5. RPA3 interacts directly with ssDNA on the 3'-side on a 31 nt ssDNA. PMID: 19010961

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 10291

    OMIM: 179837

    KEGG: hsa:6119

    STRING: 9606.ENSP00000223129

    UniGene: Hs.487540



主站蜘蛛池模板: 无码中文av有码中文av| 国产老熟妇精品观看| 少妇性l交大片欧洲热妇乱xxx| 永久免费无码日韩视频| 日韩精品人妻无码久久影院| 亚洲国产精品久久久久4婷婷| 国产乱了伦视频大全亚琴影院| 国产成人一区二区三区在线| 国产精品成人久久电影| 成人亚洲欧美久久久久| 国产精品毛片在线完整版sab| 天堂www天堂在线资源| 久久久久免费精品国产| 久久婷婷五月综合色丁香| 无码色偷偷亚洲国内自拍| 欧美色欧美亚洲日韩在线播放| 亚洲精品久久久久午夜福利| 国产精品a无线| 99re6在线视频精品免费| 国产精品理论片在线观看| 亚洲中文字幕乱码一区| 99热精品毛片全部国产无缓冲| 国产超碰人人做人人爱ⅴa| 国产婷婷色一区二区三区在线| yyyy11111少妇影院| 丰满少妇高潮惨叫久久久| 久久亚洲精精品中文字幕| 国产国语毛片在线看国产| 女人被躁到高潮免费视频软件 | 亚洲va在线va天堂xx xx| 成码无人av片在线电影网站| 成年美女黄网站色大片免费看 | 无码人妻精品一区二区三18禁| 少妇与黑人一二三区无码| 亚洲成av人片天堂网老年人| 欧美亚洲另类自拍丝袜| 国产午夜手机精彩视频| 国产互换人妻hd| 在线精品亚洲一区二区| 国产成人一区二区不卡免费视频| 国产乱码精品一区二区三区中文|