在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RPA3 Antibody

  • 中文名稱:
    RPA3兔多克隆抗體
  • 貨號:
    CSB-PA16239A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA16239A0Rb at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RPA3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    p14 antibody; REPA 3 antibody; REPA3 antibody; Replication factor A protein 3 antibody; Replication protein A 14 kDa subunit antibody; Replication protein A3 14kD antibody; Replication protein A3 14kDa antibody; Replication protein A3 antibody; RF A antibody; RF A protein 3 antibody; RF-A protein 3 antibody; RFA protein 3 antibody; RFA3_HUMAN antibody; RP A antibody; RP A p14 antibody; RP-A p14 antibody; RPA 14 antibody; RPA 3 antibody; RPA p14 antibody; rpa3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Replication protein A 14 kDa subunit protein (1-119AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,RPA3 Antibody (CSB-PA16239A0Rb),的標記方式是Non-conjugated。對于RPA3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA16239B0Rb RPA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA16239C0Rb RPA3 Antibody, FITC conjugated
    Biotin CSB-PA16239D0Rb RPA3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER), probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA. As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
  • 基因功能參考文獻:
    1. RPA3 is a potential marker of prognosis, radioresistance and survival in nasopharyngeal carcinoma. PMID: 28557284
    2. Elevated expression of RPA3 promotes tumor progression in hepatocellular carcinoma cells. PMID: 28683444
    3. Up-regulation of RPA3 is involved in gastric cancer tumorigenesis and is associated with poorer patient survival. PMID: 28766245
    4. The allele "T" of rs6947203 in the RPA3 gene acts as a protective allele in glioma. PMID: 23573956
    5. RPA3 interacts directly with ssDNA on the 3'-side on a 31 nt ssDNA. PMID: 19010961

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 10291

    OMIM: 179837

    KEGG: hsa:6119

    STRING: 9606.ENSP00000223129

    UniGene: Hs.487540



主站蜘蛛池模板: 1区2区3区高清视频| 日本高清色倩视频在线观看| 日韩乱码人妻无码超清蜜桃| 色欲久久久天天天综合网| 中文av岛国无码免费播放| 高潮好爽视频在线观看| 在线精品视频一区二区三区| 999久久久国产精品消防器材| 久久久综合九色合综国产精品| 先锋影音人妻啪啪va资源网站| 男女猛烈激情xx00免费视频| 国产亚洲精品aaaa片app| 亚洲在av人极品无码| 久久无码精品一一区二区三区| 国产裸体美女永久免费无遮挡| 国产亚洲精品久久久久久大师| 特黄做受又粗又长又大又硬| 老湿机香蕉久久久久久| 国产成人精品三级麻豆| 欧美成人片在线观看| 日韩久久无码免费毛片软件 | 欧美嫩交一区二区三区| 国产av一二三无码影片| 无遮挡又黄又刺激的视频| 亚洲国产成人久久综合碰| 欧美国产日韩亚洲中文| 小宝极品内射国产在线| 熟妇人妻久久中文字幕| 免费永久看黄神器无码软件| 国产亚洲精品久久久闺蜜| 精品国精品国产自在久国产应用| 久久久天堂国产精品女人| 亚洲欧洲日产国产 最新| 青青草原亚洲| 99久久婷婷国产综合精品 | 狠狠躁夜夜躁人人躁婷婷| 麻豆国产成人av在线播放欲色 | 久久国产福利播放| 国产特级毛片aaaaaaa高清 | 亚洲男人最新版本天堂| 欧美熟妇xxxxx欧美老妇不卡|