在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ROBO4 Antibody

  • 中文名稱:
    ROBO4兔多克隆抗體
  • 貨號:
    CSB-PA121728
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA121728(ROBO4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ECSM4 antibody; FLJ20798 antibody; Magic roundabout antibody; MGC133352 antibody; MGC133353 antibody; MRB antibody; Robo 4 antibody; ROBO4 antibody; ROBO4_HUMAN antibody; Roundabout homolog 4 antibody; Roundabout homolog 4 magic roundabout antibody; Roundabout homolog 4 Precursor antibody; Roundabout, axon guidance receptor, homolog 4 (Drosophila) antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Fusion protein of Human ROBO4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organization and function.
  • 基因功能參考文獻:
    1. Low expression level of ROBO4 is associated with evasive resistance and disease progression in cancer. PMID: 26956051
    2. GM-CSF and IL-1beta. Taken together, we demonstrated novel Robo4 functions in inflammation, i.e., it promotes IL-6 production by endothelial cells and immune cells via crosstalk. PMID: 29137978
    3. Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions. PMID: 28341181
    4. Overexpression of Roundabout4 is associated with glioma. PMID: 25859844
    5. there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy PMID: 27041242
    6. These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs. PMID: 26713366
    7. results indicate that AP-1 complexes regulate Robo4 gene expression in endothelial cells PMID: 26459591
    8. BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression. PMID: 25794001
    9. Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K/AKT and FAK signaling pathways. PMID: 25833462
    10. Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha suggesting that Robo4 is positively regulated by HIF-1alpha under normoxic and hypoxic conditions in microvascular endothelial cells in vitro. PMID: 26066603
    11. Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB PMID: 25360813
    12. This study demonistrated that roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression. PMID: 25470344
    13. Endothelial cell-specific DNA methylation pattern of the Robo4 proximal promoter is determined during cell differentiation and contributes to regulation of EC-specific Robo4 gene expression. PMID: 24855053
    14. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. PMID: 24090675
    15. Slit2-Robo4 is a key regulator of endothelial inflammation, and its dysregulation during endotoxemia is a novel mechanism for LPS-induced vascular pathogenesis. PMID: 24272999
    16. Here I will discuss the regulation mechanism of Robo4 gene expression by transcription factors and epigenetic control. [Review] PMID: 23023422
    17. SiRNA knockdown of Robo4 in pulmonary microvascular endothelial cells prevented Slit2 inhibition of Andes virus induced permeability demonstrating that Robo4 receptors determine pulmonary microvascular endothelial cells responsiveness to Slit2 PMID: 23702092
    18. targeting Slit2/Robo4 signaling may protect the integrity of the lymphatic barrier and limit the dissemination of HIV in the host. PMID: 22241990
    19. Protein expression of Slit2/3 and Robo1/4 was also identified in OVCAR-3 and SKOV-3 cells. PMID: 21465248
    20. REVIEW: Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm PMID: 21423011
    21. Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm. PMID: 20375003
    22. roundabout gene family extends beyond neuronal tissue and that roundabout/slit interactions are likely to have a role in angiogenesis PMID: 11944987
    23. We therefore hypothesize that expression of MRB is involved in regulating the migration of endothelial cells during tumor angiogenesis. PMID: 15894287
    24. Expression of Robo1 is mainly in tumor cells, whereas Robo4 is primarily in endothelial cells of tumor vessels. Therefore, the Robo proteins provide potential target structures for the anti-tumorigenic and anti-angiogenic therapy of colorectal carcinoma. PMID: 16685377
    25. 3-kb upstream promoter of human Robo4 contains information for cell type-specific expression in the intact endothelium. PMID: 17495228
    26. No evidence for association between Gilles de la Tourette Syndrome and either the ROBO4 gene. Thus, this gene is unlikely to be the susceptibility genes contributing to GTS on 11q24. PMID: 17671968
    27. One SNP of ROBO3 showed association with autism PMID: 18270976
    28. role of the GABP-binding motif in mediating Robo4 expression in the intact endothelium PMID: 18519813
    29. Robo1 is essential for Robo4-mediated filopodia induction PMID: 18948384
    30. The knockdown of robo4 abrogated the chemotactic response of endothelial cells to serum but enhanced a chemokinetic response to Slit2, while robo1 knockdown cells do not display chemotactic response to serum or VEGF. PMID: 18980679
    31. Investigated Robo4 in fibrovascular membranes (FVMs) from patients with proliferative diabetic retinopathy and in 2 cell lines. The level of Robo4 mRNA was high in FVMs. Found Robo4 may play a role in the formation of FVMs. PMID: 19495426
    32. data reveal that a Slit2-Robo4-paxillin-GIT1 network inhibits the cellular protrusive activity underlying neovascularization and vascular leak, and identify a new therapeutic target for ameliorating diseases involving the vascular system PMID: 19855388
    33. ROBO4 mRNA decreases during pulmonary fibrosis and hypertension PMID: 17496152

    顯示更多

    收起更多

  • 蛋白家族:
    Immunoglobulin superfamily, ROBO family
  • 組織特異性:
    Specifically expressed in endothelial cells. Expressed in endothelial and intimal cells of the ascending aorta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17985

    OMIM: 607528

    KEGG: hsa:54538

    STRING: 9606.ENSP00000304945

    UniGene: Hs.524121



主站蜘蛛池模板: 久青青视频在线观看久| 男女下面一进一出好爽视频| 中国xxx农村性视频| 国精产品一区一区三区| 欧美人禽杂交狂配| 成人欧美一区二区三区黑人 | 精品久久久噜噜噜久久久| 大陆精大陆国产国语精品| 亚洲gv天堂无码男同在线观看 | 国产香蕉97碰碰久久人人| 97人妻人人揉人人躁人人| 久久久精品久久久久久96| 亚洲国产精品久久久久网站| 免费观看又色又爽又湿的软件| 未满小14洗澡无码视频网站| 超碰色偷偷男人的天堂| 国精品人妻无码一区免费视频电影| 日韩 亚洲 欧美 国产 精品| 国产成人无码www免费视频播放| 欧美国产综合欧美视频| 国产高清乱码又大又圆| 久久精品亚洲综合专区| 国产乱人伦偷精品视频不卡| 精品爆乳一区二区三区无码av| 男女下面一进一出好爽视频| 精品免费国产一区二区三区四区介绍| 久久精品一区二区三区四区| 2019最新久久久视频精品| 丰满人妻被黑人中出849| 性高朝久久久久久久| 色狠狠久久av五月综合| 天天澡日日澡狠狠欧美老妇| 国产av天堂亚洲国产av麻豆| 美女无遮挡免费视频网站| 女人18毛片水真多免费看| 少妇被又大又粗又爽毛片| 国内精品久久久久影院日本| 免费观看全黄做爰的视频| 免费看美女部位隐私网站| 国产成人一区二区三区免费| 亚洲人亚洲精品成人网站|