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  4. RNF6 Antibody, Biotin conjugated

RNF6 Antibody, Biotin conjugated

  • 中文名稱：
    RNF6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA897080LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNF6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF6
  • 別名：
    E3 ubiquitin-protein ligase RNF6 antibody; Ring finger protein (C3H2C3 type) 6 antibody; Ring finger protein 6 antibody; RING H2 protein antibody; RING H2 protein RNF6 antibody; RNF 6 antibody; RNF6 antibody; RNF6_HUMAN antibody; SPG2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF6 protein (1-298AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
  • 基因功能參考文獻：
    1. High RNF6 expression is associated with breast cancer. PMID: 28223545
    2. This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia. PMID: 26971355
    3. Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics PMID: 16204183
    4. Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2, in human development. PMID: 18368307
    5. Functional anaylysis of the mouse homolog PMID: 11971979

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  • 相關疾病：
    Esophageal cancer (ESCR)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body.
  • 蛋白家族：
    RNF12 family
  • 組織特異性：
    Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
  • 數據庫鏈接：

    HGNC: 10069

    OMIM: 133239

    KEGG: hsa:6049

    STRING: 9606.ENSP00000342121

    UniGene: Hs.136885



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