在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RNF34 Antibody

  • 中文名稱:
    RNF34兔多克隆抗體
  • 貨號:
    CSB-PA019886GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    RNF34
  • 別名:
    CARP 1 antibody; CARP-1 antibody; CARP1 antibody; Caspase regulator CARP1 antibody; Caspases-8 and -10-associated RING finger protein 1 antibody; E3 ubiquitin-protein ligase RNF34 antibody; FYVE-RING finger protein Momo antibody; hRFI antibody; Human RING finger homologous to inhibitor of apoptosis protein antibody; RFI antibody; RIF antibody; RIFF antibody; RING finger protein 34 antibody; RING finger protein RIFF antibody; RNF34 antibody; RNF34_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RNF34
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
  • 基因功能參考文獻(xiàn):
    1. Data indicate that E3 ligase RNF34 is associated with nucleotide-binding oligomerization domain-containing protein 1 (NOD1). PMID: 25012219
    2. Data indicate AE induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of CARP mRNAs in a p53-independent manner. PMID: 21308745
    3. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. PMID: 20564261
    4. a novel gene, hRFI, preferentially expressed in esophageal cancer (hRFI) PMID: 12118383
    5. hRFI may act as an oncogenic molecule affecting the apoptotic pathway PMID: 15595643
    6. CARPs together with MDM2 enhance p53 degradation, thereby inhibiting p53-mediated cell death. PMID: 18382127

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Nucleus. Nucleus speckle. Cytoplasm, cytosol.
  • 組織特異性:
    Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17297

    OMIM: 608299

    KEGG: hsa:80196

    STRING: 9606.ENSP00000376258

    UniGene: Hs.292804



主站蜘蛛池模板: 久久国产偷任你爽任你| 青草视频在线观看视频| 又黄又硬又湿又刺激视频免费 | 妺妺窝人体色www在线| 亚洲色成人网站永久| 国产亚洲精品一区二三区| 国产成人av男人的天堂| 无码欧精品亚洲日韩一区 | 高清欧美性猛交xxxx黑人猛交| 国产人妻鲁鲁一区二区| av色国产色拍| 又紧又黄的免费视频网站| 乱人伦人妻中文字幕无码| 欧美丰满少妇xxxx性| 久久亚洲色www成人男男| 午夜精品影视国产一区在线麻豆 | 国产一区二区三区不卡在线看 | 无码一区二区三区| 日韩欧美亚洲综合久久影院d3| 蜜柚av久久久久久久| 亚洲一区二区三区影院| 精品人妻一区二区三区四区在线| 国产精品免费观看调教网| 亚洲人毛茸茸bbxx| 99久久久国产精品无码免费| 大桥未久亚洲一区二区| 中文字幕 乱码 中文乱码视频| 亚洲综合久久一区二区| 妺妺窝人体色www在线| 欧美人与动zozo在线播放| 中文字幕av一区| 国产人妻精品一区二区三区| 麻豆精品人妻一区二区三区蜜桃 | 一本一久本久a久久精品综合| 亚洲精品无码久久久久久| 国产99视频精品专区| 无码帝国www无码专区色综合| 午夜亚洲www湿好爽| 成年片色大黄全免费软件到| 最近日本精品一卡2卡3卡4卡| 18禁免费无码无遮挡不卡网站|