在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RNF31 Antibody, Biotin conjugated

  • 中文名稱:
    RNF31兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA856927LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RNF31 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    E3 ubiquitin protein ligase RNF31 antibody; FLJ10111 antibody; FLJ23501 antibody; HOIL 1L interacting protein antibody; HOIL-1-interacting protein antibody; HOIL1L interacting protein antibody; HOIP antibody; RING finger protein 31 antibody; RNF31 antibody; RNF31_HUMAN antibody; ZIBRA antibody; Zinc in between ring finger ubiquitin associated domain antibody; Zinc in-between-RING-finger ubiquitin-associated domain protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation. Binds polyubiquitin of different linkage types.
  • 基因功能參考文獻:
    1. The binding of SHARPIN or HOIL-1L facilitates the E2 loading of HOIP. PMID: 28978479
    2. SPATA2 has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP and CYLD, thereby enabling recruitment of CYLD to signaling complexes. PMID: 27545878
    3. This review highlights recent discoveries on RNF31 functions in nuclear factor modifications, breast cancer progression and possible therapeutic inhibitors targeting RNF31. [review] PMID: 27460922
    4. The data reveal SPATA2 as a high-affinity binding partner of CYLD and HOIP, and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB signaling. PMID: 27591049
    5. LUBAC components control TLR3-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation. PMID: 27810922
    6. Study found that RNF31 is cleaved under apoptosis conditions through various stimulations; findings elucidate a novel regulatory loop between cell death and the survival signal PMID: 27669734
    7. These results indicate that caspase-mediated cleavage of HOIP divides critical functional regions of HOIP, and that this regulates linear (de)ubiquitination of substrates upon apoptosis. PMID: 28189684
    8. RNF31 decreased p53 stability. RNF31 depletion caused cell cycle arrest and cisplatin-induced apoptosis in a p53-dependent manner. RNF31 associated with the p53/MDM2 complex, facilitating p53 polyubiquitination and degradation by stabilizing MDM2. PMID: 26148235
    9. This study describes a novel posttranslational regulation of the HOIP-containing linear-ubiquitin-chain assembly complex (LUBAC)-mediated linear ubiquitination that is critical for specifically directing TLR4-mediated NF-kappaB activation. PMID: 26578682
    10. These findings collectively indicated an oncogene role of RNF31 in PCa progression which can be regulated by miR-503, suggesting that RNF31 could serve as a potential prognostic biomarker and therapeutic target for PCa. PMID: 26231797
    11. we identified BCL10 as a bona fide target of BCR-induced linear ubiquitylation and demonstrated an important role of the linear ubiquitin ligase HOIP in BCR-induced phosphorylation PMID: 26038114
    12. crystal structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation PMID: 26789245
    13. human HOIP is essential for the assembly and function of LUBAC, which includes HOIL-1, and for various processes governing inflammation and immunity in both hematopoietic and nonhematopoietic cells PMID: 26008899
    14. Two rare germline polymorphisms affecting the LUBAC subunit RNF31 were identified and enriched among patients with activated B cell-like subtype of diffuse large B-cell lymphoma. PMID: 24491438
    15. RNF31, via stabilizing ESR1 levels, controls the transcription of estrogen-dependent genes linked to breast cancer cell proliferation. PMID: 24441041
    16. Phosphorylation of OTULIN prevents HOIP binding, whereas unphosphorylated OTULIN is part of the endogenous LUBAC complex. PMID: 24726323
    17. HOIP binding to OTULIN is required for the recruitment of OTULIN to the TNF receptor complex. PMID: 24726327
    18. target specificity toward NEMO is determined by multiple LUBAC components, whereas linear ubiquitin chain elongation is realized by a specific interplay between HOIP and ubiquitin. PMID: 24030825
    19. crystal structure of the catalytic core of HOIP in its apo form and in complex with ubiquitin PMID: 24141947
    20. The HOIP component of the linear ubiquitin assembly complex catalyzes the formation of M1-polyubiquitin chains in response to interleukin-1. PMID: 23986494
    21. The data showed how HOIP combines a general RING-IBR-RING ubiquitin ligase mechanism with unique, 'Linear ubiquitin chain Determining Domain'-dependent specificity for producing linear ubiquitin chains. PMID: 22863777
    22. analysis of differentially expressed genes indicates systemic role for SF-1 in adrenal cortex affecting differentiation, proliferation and steroidogenesis and establishes RNF31 as an important regulator of adrenal steroidogenesis PMID: 22427816
    23. The study highlights the versatility and specificity of protein-protein interactions involving Ub-like domain (UBL) of HOIL-1L/the Ub-associated domain (UBA) of HOIP and their cognate proteins. PMID: 22430200
    24. ZIBRA was identified and its genomic organization, regulation, and expression studied in breast cancer cells. PMID: 15093743
    25. RNF31 functions to stabilize DAX-1; RNF31 appears to be required for DAX-1 to repress transcription PMID: 19237537

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 組織特異性:
    Expressed in both normal and transformed breast epithelial cell lines.
  • 數據庫鏈接:

    HGNC: 16031

    OMIM: 612487

    KEGG: hsa:55072

    STRING: 9606.ENSP00000315112

    UniGene: Hs.375217



主站蜘蛛池模板: 一边捏奶一边高潮视频| 亚洲大尺度无码无码专线| 精品国产v无码大片在线观看| 四虎精品成人a在线观看| 又粗又硬又大又爽免费视频播放 | 无码一区二区波多野结衣播放搜索| 2019最新久久久视频精品| 中文人妻无码一区二区三区在线| 少妇群交换bd高清国语版| 欧美老熟妇xb水多毛多| 亚洲国产欧美在线观看| 国产av麻豆mag剧集| 国产亚洲一卡2卡3卡4卡网站| 久久国产欧美成人av| 18女下面流水不遮图| 人妻av中文系列| 性色欲情网站iwww| 无码免费无线观看在线视| 朝鲜女子内射杂交bbw| 亚洲色偷拍另类无码专区| 久久中文字幕人妻av熟女| 日韩亚洲国产综合高清 | 波多野结衣不打码视频| 99精品国产99久久久久久97| 伊人精品成人久久综合| 亚洲自偷自拍另类12p| 秋霞av在线露丝片av无码 | 一区二区传媒有限公司| 国精产品一二三区精华液| 伊人久久精品在热线热| 在线|国产精品女主播阳台| 国产欧美va天堂在线观看视频| 大学生高潮无套内谢视频| 免费看成人午夜福利专区| 国产av无码专区影视| 97色偷偷色噜噜狠狠爱网站| 亚洲日韩久热中文字幕| 亚洲综合精品香蕉久久网| 四虎国产精品永久在线观看| 无码国产69精品久久久久同性 | 精品国产成人高清在线观看|