在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF185 Antibody

RNF185 Antibody

  • 中文名稱：
    RNF185兔多克隆抗體
  • 貨號：
    CSB-PA251137
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA251137(RNF185 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    RNF185; E3 ubiquitin-protein ligase RNF185; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human RNF185
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
  • 基因功能參考文獻：
    1. increased RNF185 expression facilitated GC cell migration in vitro and promoted GC metastasis in vivo by downregulating JWA expression. PMID: 29481911
    2. this study uncovers RNF185 as the first E3 ubiquitin ligase of cyclic GMP-AMP synthase (cGAS), shedding light on the regulation of cGAS activity in innate immune responses PMID: 28273161
    3. these results indicate that RNF185 negatively regulates osteogenesis through the degradation of Dvl2 and down-regulation of canonical Wnt signaling pathway and suggest a possible therapeutic target in osteoporosis. PMID: 24727453
    4. data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR degradation. PMID: 24019521
    5. Human BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage in vivo. PMID: 21931693

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 26783

    KEGG: hsa:91445

    STRING: 9606.ENSP00000320508

    UniGene: Hs.517553



主站蜘蛛池模板： 女人与牲口性恔配视频免费| 成人av片无码免费网站| 成人免费视频在线观看| 国产99视频精品免费视看9| 欧洲熟妇色xxxxx视频 | 国产偷窥盗摄一区二区| 成人免费无码大片a毛片户外| 国产成人小说视频在线观看| 精品无人国产偷自产在线| 亚洲精品自在在线观看| 国产午夜精品理论片| 亚洲色无码专线精品观看| 人人爽人人爽人人片a免费| 亚洲aⅴ无码专区在线观看q| 成人免费国产精品视频| 熟女无套内射线观56| 末发育女av片一区二区| 国产午夜鲁丝片av无码免费| 国产 亚洲 制服 无码 中文 | 国产草草影院ccyycom| 国产熟女一区二区三区四区五区| 亚洲一区无码中文字幕乱码| 大香伊蕉在人线国产最新75 | 最近日本免费观看高清视频| 中文字幕乱码人妻一区二区三区| 久久久天堂国产精品女人| 变态另类牲交乱| 亚洲性无码av在线dvd| 在线a亚洲视频播放在线观看| 欧美牲交a欧美牲交aⅴ另类| 国产饥渴孕妇在线播放| 九九久久精品国产| 亚洲人成无码网站久久99热国产| 99er国产这里只有精品视频免费 | 国产午夜鲁丝片av无码免费| 搡老女人老妇女老熟妇| 久久人人爽人人爽人人片ⅴ| 日韩亚洲中字无码一区二区三区| 中文字幕亚洲综合久久蜜桃| 精品黑人一区二区三区久久| 四虎成人永久在线精品免费|