在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RNF139 Antibody

  • 中文名稱:
    RNF139兔多克隆抗體
  • 貨號:
    CSB-PA280050
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA280050(RNF139 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA280050(RNF139 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RNF139
  • 別名:
    RNF139 antibody; TRC8 antibody; E3 ubiquitin-protein ligase RNF139 antibody; EC 2.3.2.27 antibody; RING finger protein 139 antibody; RING-type E3 ubiquitin transferase RNF139 antibody; Translocation in renal carcinoma on chromosome 8 protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human RNF139
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination.
  • 基因功能參考文獻:
    1. Low RNF139 expression is associated with progression of tongue cancer. PMID: 28662643
    2. interaction with Bag1 then shifts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as determined by siRNA screening PMID: 27998983
    3. TRC8 and TMEM129 are endoplasmic reticulum-associated degradation ubiquitin E3 ligases for viral and cellular targeting of MHC class I. (Review) PMID: 26210183
    4. TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation. PMID: 22689053
    5. TRC8 function may provide a regulatory link between the lipid and protein biosynthetic pathways. PMID: 20068067
    6. TRC8 modulation of sterol response element binding protein activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway. PMID: 17016439
    7. The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages. PMID: 17539022
    8. TRC8 is a novel sterol-sensing endoplasmic reticulum membrane protein that hinders SREBP-2 processing through interaction with SREBP-2 and SCAP, regulating its own turnover rate by means of its E3 ubiquitin ligase activity PMID: 19706601
    9. Data show that the TRC8 E3 ligase is required for MHC I dislocation from the ER and identify a new complex associated with mammalian ERAD. PMID: 19720873

    顯示更多

    收起更多

  • 相關疾病:
    Renal cell carcinoma (RCC)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 組織特異性:
    Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney.
  • 數據庫鏈接:

    HGNC: 17023

    OMIM: 144700

    KEGG: hsa:11236

    STRING: 9606.ENSP00000304051

    UniGene: Hs.744151



主站蜘蛛池模板: 亚洲欧美日韩二三区在线| 六月丁香亚洲综合在线视频 | 曰本极品少妇videossexhd| 97se亚洲综合自在线| 国产男女免费完整视频在线| √天堂中文最新版在线中文| 国产熟妇乱子伦视频在线观看| 亚洲女人被黑人巨大进入| 日本大尺度吃奶呻吟视频| 狠狠色综合网久久久久久| 中文字幕人妻熟女人妻a片| 好日子在线观看视频大全免费动漫| 日产精品中文一区二区三区| 伊人久久大香线蕉综合中文字幕| 麻豆av一区二区三区| 伊人激情av一区二区三区| 久久99精品久久久久久齐齐 | 日韩aⅴ人妻无码一区二区| 精品无码国产一区二区三区51安| 中文字幕乱码人妻一区二区三区| 欧美高清性色生活片免费观看| 国产丝袜在线精品丝袜不卡| 午夜人成免费视频| 国产精品久久久爽爽爽麻豆色哟哟 | 国产无套精品一区二区| 一区二区三区人妻无码| 成人亚洲欧美在线观看| 男女猛烈无遮挡免费视频app| 天天干天天日夜夜操| 肥臀浪妇太爽了快点再快点| 亚洲另类成人小说综合网| 日韩人妻少妇一区二区三区| 少妇无码一区二区三区免费| 伊人情人综合网| 国产香港明星裸体xxxx视频| a毛片免费全部播放自慰| 久久精品伊人一区二区三区| 无码av免费精品一区二区三区 | 激情偷乱人伦小说视频在线| 熟妇人妻无码中文字幕老熟妇| 自拍校园亚洲欧美另类|