在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF138 Antibody, FITC conjugated

RNF138 Antibody, FITC conjugated

  • 中文名稱：
    RNF138兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA851971LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RNF138 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF138
  • 別名：
    E3 ubiquitin protein ligase RNF138 antibody; E3 ubiquitin-protein ligase RNF138 antibody; hNARF antibody; HSD 4 antibody; HSD4 antibody; MGC8758 antibody; NARF antibody; Nemo like kinase associated RING finger protein antibody; Nemo-like kinase-associated RING finger protein antibody; NLK associated RING finger protein antibody; NLK-associated RING finger protein antibody; RING finger protein 138 antibody; ring finger protein 138, E3 ubiquitin protein ligase antibody; RN138_HUMAN antibody; Rnf138 antibody; STRIN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF138 protein (2-245AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
  • 基因功能參考文獻(xiàn)：
    1. Study suggested that RNF138 was important for the proliferation, migration and invasion of glioma cells. Its downregulation inhibited the process of EMT by suppressing Erk signaling pathway in glioma. PMID: 30272353
    2. This study identify RNF138 as the E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human CaV2.1 protein. PMID: 28167673
    3. Rad51d mediated by E3 Ligase Rnf138 has a role in the homologous recombination repair pathway PMID: 27195665
    4. RNF138 is a newly identified regulatory component of the HR mediated DNA repair pathway that has implications toward understanding how ubiquitination modifies the functions of the RAD51 paralog protein complex PMID: 27161866
    5. Data show that ubiquitin E3 ligase RNF138 regulates Ku80 antigen ubiquitylation in response to DNA damage. PMID: 26502055
    6. Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual. PMID: 26502057
    7. The RNF138 gene is highly expressed in glioma tissue and glioma cell lines and plays an important role in glioma cell proliferation, apoptosis, and cell cycle. PMID: 22155992

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Chromosome.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17765

    OMIM: 616319

    KEGG: hsa:51444

    STRING: 9606.ENSP00000261593

    UniGene: Hs.302408



主站蜘蛛池模板： 亚洲国产福利一区二区三区| 久久亚洲道色综合久久| 国产午夜成人无码免费| 国产成人一区二区三区app | 欧美日韩色另类综合| 国产精品香港三级国产av| 7777精品伊久久久大香线蕉| 玖玖资源站无码专区| 人妻夜夜添夜夜无码av| 色狠狠色噜噜av天堂一区| 午夜电影网va内射| 国内久久婷婷六月综合欲色啪 | 日韩一区二区三区北条麻妃| 精品国产一区二区三区av色诱| 精品人无码一区二区三区| 成人无码www免费视频| 亚洲第一成年免费网站| 国产果冻豆传媒麻婆| 国产裸拍裸体视频在线观看| 特级做a爰片毛片免费看108| 国产在线无码一区二区三区| 久久99精品网久久| 88国产精品视频一区二区三区| 久久中文字幕人妻丝袜| 做性久久久久久| 欧美黑人巨大videos精品| 小蜜被两老头吸奶头在线观看| 一二三四视频社区3在线高清| 又粗又黄又猛又爽大片免费| 乱人伦人妻精品一区二区| 99久久精品无码一区二区毛片| 少妇乳大丰满在线播放| 国产精品区av| 韩国精品福利一区二区三区| 国产无限次数成版人视频在线| 日本特黄aaaaaa大片| 国产精品自在线拍国产手机版| 亚洲欧美日韩国产综合在线一区| 蜜臀av片在线观看| 亚洲日韩欧美国产高清αv| 亚洲久久中文字幕www网站|