在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF11 Antibody

RNF11 Antibody

  • 中文名稱：
    RNF11兔多克隆抗體
  • 貨號：
    CSB-PA134767
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA134767(RNF11 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA134767(RNF11 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RNF11
  • 別名：
    CGI 123 antibody; RING finger protein 11 antibody; RNF11 antibody; RNF11_HUMAN antibody; Sid 1669 antibody; SID1669 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human RNF11
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
  • 基因功能參考文獻：
    1. data suggest for the first time that the choice of binding partners for SMURF2 can sustain or repress TGFbeta signaling, and RNF11 may promote TGFbeta-induced cell migration. PMID: 28292929
    2. Up-regulation of COPII components requires the transcriptional regulator RNF11, which localizes to early endosomes and appears additionally in the cell nucleus upon continuous EGF stimulation. PMID: 27872256
    3. RNF11 is at the center of a finally regulated system where it acts both as an adaptor and a modulator of itch-mediated control of ubiquitination events underlying membrane traffic. PMID: 25195858
    4. Our data exemplifies the relevance of RNF11 and persistent NF-kappaB activation in Parkinson's disease PMID: 23669642
    5. The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. PMID: 23222715
    6. RNF11 functions together with TAX1BP1 to restrict antiviral signaling and IFN-beta production. PMID: 23308279
    7. RNF11 negatively regulates canonical NF-kappaB signaling in the nervous system. PMID: 22507528
    8. Microglial RNF11 is a negative regulator of NF-kappaB signalling pathway and could be a strong potential target for modulating inflammatory responses in neurodegenerative diseases. PMID: 22975135
    9. Data show that membrane anchoring through acylation is necessary for RNF11 to be post-translationally modified by the addition of several ubiquitin moieties. PMID: 20676133
    10. overexpression of RNF11, through its interaction with Smurf2, can restore TGFbeta responsiveness in transfected tumor cells PMID: 14562029
    11. characterization of ring finger protein 11 PMID: 16123141
    12. RNF11 is a small RING E3 ligase that affects transforming growth factorbeta and EGF-R signaling and is overexpressed in invasive breast cancers PMID: 16925951
    13. these findings identify RNF11 as a strong candidate gene at the PARK10 locus and highlight its potential significance in the development of the common form of Parkinson disease PMID: 17917589
    14. Analysis reveals that the main determinants of selectivity between ubiquitin ligases RNF11 and E2 ubiquitin-conjugating enzymes resides on ring domains, rather than on the E2s. PMID: 18615712
    15. RNF11, together with TAX1BP1 and Itch, is an essential component of an A20 ubiquitin-editing protein complex that ensures transient activation of inflammatory signalling pathways. PMID: 19131965

    顯示更多

    收起更多

  • 亞細胞定位：
    Early endosome. Recycling endosome. Cytoplasm. Nucleus.
  • 組織特異性：
    Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skele
  • 數據庫鏈接：

    HGNC: 10056

    OMIM: 612598

    KEGG: hsa:26994

    STRING: 9606.ENSP00000242719

    UniGene: Hs.309641



主站蜘蛛池模板： 真人抽搐一进一出视频| 国产深夜福利视频在线| 精品亚洲国产成人av在线小说| 亚洲熟妇av一区二区三区漫画| 国产精品乱码一区二区三区| 国产ae86亚洲福利入口| 国产成人综合亚洲看片| 亚洲色丰满少妇高潮18p| 国模欢欢炮交啪啪150| 久久久久青草线蕉亚洲麻豆| 国产欧美另类久久久精品不卡| 日韩少妇内射免费播放18禁裸乳 | 无码一区二区三区av免费| 男女性潮高清免费网站| 无码av高潮喷水无码专区线| 香港aa三级久久三级| 国产综合色在线视频区| 中文天堂在线资源www| 亚洲国产香蕉碰碰人人| 伦伦影院午夜理论片| 国产午夜鲁丝无码拍拍| 一边做一边喷17p亚洲乱妇50p| 夜夜高潮夜夜爽夜夜爱爱一区| 中国国语毛片免费观看视频| 日本久久综合久久综合| 亚洲国产精品无码专区影院| 日韩乱码人妻无码超清蜜桃| 国产精品亚洲综合一区在线观看 | 狠狠躁夜夜躁人人爽天天| 伊人久久大香线蕉av仙人| 亚洲精品中文字幕无码蜜桃| 久久久久久久极品内射| 日韩一区二区三区射精| 男女猛烈无遮挡免费视频在线观看| 亚洲精品一区二区三区四区五区| 亚洲妇女水蜜桃av网网站| 熟女丝袜潮喷内裤视频网站| 日日躁夜夜躁狠狠久久av| 好大好湿好硬顶到了好爽视频| 无码中文字幕免费一区二区三区 | 曰韩内射六十七十老熟女影视|