在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNASET2 Antibody

RNASET2 Antibody

  • 中文名稱：
    RNASET2兔多克隆抗體
  • 貨號：
    CSB-PA443565
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA443565(RNASET2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RNASET2
  • 別名：
    bA514O12.3 antibody; Ribonuclease 6 antibody; Ribonuclease T2 antibody; RNASE6PL antibody; Rnaset2 antibody; RNT2_HUMAN antibody; RP11 514O12.3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human RNASET2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
  • 基因功能參考文獻：
    1. High RNASET2 expression is associated with reduced sperm motility. PMID: 29581387
    2. Studied association of and RNASET2, GPR174, and PTPN22 gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 were significantly associated with altered GD-derived LD risk. PMID: 28568286
    3. RNASET2 is the enzyme that degrades the RNAs PMID: 28730546
    4. RNASET2, an IBD susceptibility gene, is a component of TL1A-mediated pathways regulating cytokine production. PMID: 28400196
    5. inhibits melanocyte outgrowth through interacting with shootin1; this effect may be associated with vitiligo pathogenesis PMID: 26293343
    6. Biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation. PMID: 25797262
    7. RNASET2 may contribute to the development of vitiligo by inhibiting TNF Receptor-Associated Factor 2 expression and lead directly to apoptosis of melanocytes PMID: 26067323
    8. describe a multi-step strategy that allows production of highly pure, catalytically competent recombinant RNASET2 in both wild-type and mutant forms PMID: 25663099
    9. RNASET2 has antitumorigenic and antiangiogenic activities; a truncated version of human RNASET2, starting at E50 (trT2-50) and devoid of ribonuclease activity, has actin binding and anticancer-related biological activities PMID: 25426551
    10. RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population PMID: 25928629
    11. Results show that downregulation of RNASET2 and GGNBP2 in drug-resistant ovarian cancer tissues/cells contributes to the regulation of drug resistance in ovarian cancer. PMID: 24842157
    12. RNASET2 contributes to vitiligo pathogenesis by inhibiting TRAF2 expression. PMID: 24457966
    13. Genotypes of single nucleotide polymorphisms (SNPs) in RNASET2 gene were determined. PMID: 24327149
    14. Ribonuclease T2, an ancient and phylogenetically conserved RNase, has a role in development of ovarian neoplasms PMID: 23630276
    15. Higher expression of RNASET2 in the semen of asthenozoospermia individuals may contribute to sperm motility impairment. PMID: 23258633
    16. RNASET2--an autoantigen in anaplastic large cell lymphoma identified by protein array analysis. PMID: 22732457
    17. The catalytic features of RNase T2 in presence of bivalent cations were analyzed and the structural consequences of known clinical mutations were investigated. PMID: 22735700
    18. a possible involvement of RNASET2 in P-body formation in mammalian cells. PMID: 22188480
    19. Tax represses expression of RNase T2. PMID: 21994792
    20. Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells. PMID: 21646684
    21. The expression of the human tumor suppressor protein RNASET2 was studied in baculovirus-insect cell and Pichia pastoris heterologous systems. PMID: 21446958
    22. Familial cystic leukoencephalopathy arising in RNASET2-deficient humans is a manifestation of an lysosomal storage disorders in which rRNA is the best candidate for the noxious storage material. PMID: 21199949
    23. RNaseT2 is a cell growth regulator and it does not induce senescence in SV40 immortalized cell lines. PMID: 19382914
    24. RNASET2 found to significantly decrease the metastatic potential of ovarian cancer cell line in vivo; tumor suppression by RNASET2 is suggested to not be mediated by its ribonuclease activity PMID: 15809705
    25. The results presented herein represent a further advancement toward the molecular understanding of the tumour suppressive properties of the human RNASET2 protein. PMID: 16620762
    26. Loss of RNASET2 is associated with melanoma PMID: 18543608
    27. Study shows that loss-of-function mutations in the gene encoding the RNASET2 glycoprotein lead to cystic leukoencephalopathy, an autosomal recessive disorder with an indistinguishable clinical and neuroradiological phenotype. PMID: 19525954

    顯示更多

    收起更多

  • 相關疾病：
    Leukoencephalopathy, cystic, without megalencephaly (LCWM)
  • 亞細胞定位：
    Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Mitochondrion intermembrane space.
  • 蛋白家族：
    RNase T2 family
  • 組織特異性：
    Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
  • 數據庫鏈接：

    HGNC: 21686

    OMIM: 612944

    KEGG: hsa:8635

    STRING: 9606.ENSP00000422846

    UniGene: Hs.529989



主站蜘蛛池模板： 免费夫妻生活片av| 免费无遮挡禁18污污网站| 精品人妻无码一区二区三区蜜桃一| 精品久久国产综合婷婷五月| 午夜精品国产精品大乳美女| 亚洲综合区图片小说区| 无码熟妇人妻av在线影片免费 | √最新版天堂资源网在线下载 | 免费的污污的网站在线观看| 狠狠爱亚洲五月婷婷av| 野外做受又硬又粗又大视频| 亚洲а∨天堂男人色无码| 伊人蕉影院久亚洲高清| 久久精品国产久精国产一老狼| 苍井空张开腿实干12次| 亚洲精品国产精品乱码不卡√| 日韩免费人妻av无码专区蜜桃| 欧美极品video粗暴| 国产 麻豆 日韩 欧美 久久 | 国产9 9在线 | 免费| 亚洲综合色自拍一区| 国产精品麻豆欧美日韩ww| 日本三级在线播放线观看视频| 人妻护士在线波多野结衣| 亚洲精品美女久久久久99| 免费人成在线观看视频播放| 国产成人无码一区二区三区| 欧美精品18videos性欧美| 一区三区不卡高清影视| 婷婷五月婷婷五月| 国产对白老熟女正在播放| 亚洲风情亚aⅴ在线发布 | 久久精品人人做人人爱爱漫画 | 先锋人妻无码av电影| 先锋影音xfyy5566男人资源| 亚洲 另类 熟女 字幕| 国产精品久久久福利| 99精品国产福久久久久久| 草草网站影院白丝内射| 日日摸日日碰夜夜爽免费| 天堂网在线最新版www中文网|