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RNASEH2A Antibody

  • 中文名稱：
    RNASEH2A兔多克隆抗體
  • 貨號：
    CSB-PA019805LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA019805LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNASEH2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNASEH2A
  • 別名：
    RNASEH2A antibody; RNASEHI antibody; RNHIA antibody; Ribonuclease H2 subunit A antibody; RNase H2 subunit A antibody; EC 3.1.26.4 antibody; Aicardi-Goutieres syndrome 4 protein antibody; AGS4 antibody; RNase H(35) antibody; Ribonuclease HI large subunit antibody; RNase HI large subunit antibody; Ribonuclease HI subunit A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ribonuclease H2 subunit A protein (201-299AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，RNASEH2A Antibody (CSB-PA019805LA01HU)，的標記方式是Non-conjugated。對于RNASEH2A Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA019805LB01HU RNASEH2A Antibody, HRP conjugated ELISA
    FITC CSB-PA019805LC01HU RNASEH2A Antibody, FITC conjugated
    Biotin CSB-PA019805LD01HU RNASEH2A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
  • 基因功能參考文獻：
    1. The expression levels of RNASEH2A, CDK1, and CD151 and their combination could predict the survival of renal cell carcinoma patients. PMID: 29843367
    2. RNaseH2A may be involved in human gliomagenesis. PMID: 27176716
    3. This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2A in patients with Aicardi-Goutieres Syndrome. PMID: 27643693
    4. RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner. PMID: 24986920
    5. Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA. PMID: 25703292
    6. study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype PMID: 23592335
    7. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome PMID: 21454563

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  • 相關疾病：
    Aicardi-Goutieres syndrome 4 (AGS4)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    RNase HII family, Eukaryotic subfamily
  • 數據庫鏈接：

    HGNC: 18518

    OMIM: 606034

    KEGG: hsa:10535

    STRING: 9606.ENSP00000221486

    UniGene: Hs.532851



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