在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RMI1 Antibody, FITC conjugated

  • 中文名稱:
    RMI1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA875699LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RMI1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RMI1
  • 別名:
    BLAP75 antibody; BLM associated polypeptide 75 kDa antibody; BLM associated protein 75 kDa antibody; BLM-associated protein of 75 kDa antibody; C9orf76 antibody; FAAP75 antibody; FLJ12888 antibody; Homolog of yeast RecQ mediated genome instability 1 antibody; RecQ mediated genome instability 1 antibody; RecQ-mediated genome instability protein 1 antibody; Rmi1 antibody; RMI1 homolog antibody; RMI1 RecQ mediated genome instability 1 homolog antibody; RMI1_HUMAN antibody; RP11-346I8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human RecQ-mediated genome instability protein 1 protein (181-443AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
  • 基因功能參考文獻:
    1. RMI1 knockdown cells exhibit accumulation of broken DNAs after being released from hydroxyurea treatment. Moreover, we demonstrate that RMI1 facilitates the recovery from activated checkpoint and resuming the cell cycle after replicative stress. PMID: 29042194
    2. RMI1 protein level does not change through G1, S and G2 phases, but significantly increases in M phase. PMID: 26556339
    3. a model that maps all functionally important structural features for yeast Rmi1 and structure-prediction-based alignment with the recently established crystal structure of the N-terminus of human Rmi1, is proposed. PMID: 26717309
    4. The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex. PMID: 25200081
    5. two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner. PMID: 24108125
    6. RMI1 is required to promote normal replication fork progression PMID: 22645306
    7. Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex PMID: 20826342
    8. human topoisomerase IIIalpha functions as a decatenase with the assistance of BLM and RMI1 to facilitate the processing of homologous recombination intermediates without crossing over as a mechanism to preserve genome integrity PMID: 20445207
    9. No evidence was found for an association between RMI1 S455N (rs1982151) and colorectal cancer risk. PMID: 19945966
    10. BLAP75/RMI1 acts by recruiting TOPO IIIalpha to double Holliday junctions PMID: 16537486
    11. BLM, Topo IIIalpha, and BLAP75 constitute a dissolvasome complex that processes HR intermediates to limit DNA crossover formation PMID: 16595695
    12. BLM is stably associated with RMI1 protein. PMID: 17728255
    13. Genetic variant of the human homologous recombination-associated gene RMI1 is associated with acute myeloid leukemia, myelodysplatic syndromes and malignant melanoma PMID: 17900800
    14. evolutionarily conserved N-terminal third of BLAP75 mediates complex formation with BLM and Topo IIIalpha and that the DNA binding activity resides in the C-terminal third of this novel protein. PMID: 18390547
    15. Individuals carrying genetic variants of the BLM-TOP3A-RMI1 complex have an increased risk of acute myeloid leukemia/myelodysplatic syndromes, malignant melanoma, bladder and breast cancer. PMID: 19432957

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Forms foci in response to DNA damage.
  • 蛋白家族:
    RMI1 family
  • 數據庫鏈接:

    HGNC: 25764

    OMIM: 610404

    KEGG: hsa:80010

    STRING: 9606.ENSP00000317039

    UniGene: Hs.726327



主站蜘蛛池模板: 国产在线精品一区二区夜色| 亚洲va国产va天堂va久久| 在线观看特色大片免费网站| 国产suv精品一区二区883| av高清无码 在线播放| 久久婷婷色综合老司机| 伊人久久精品无码二区麻豆 | 国产98在线 | 欧美| 日韩毛片免费无码无毒视频观看| 丰满岳乱妇在线观看中字无码| 超碰色偷偷男人的天堂| 中文字幕亚洲制服在线看| 在线看片免费人成视频国产片| 国产亚洲精品久久无码98| 久久久久久成人毛片免费看| 人妻少妇偷人精品无码| 曰韩精品无码一区二区视频| 18禁男女无遮挡啪啪网站| 欧美丰满老熟妇aaaa片| 真人祼交二十三式视频| 人人玩人人添人人澡| 鲁一鲁一鲁一鲁一曰综合网| 7777久久久国产精品消防器材| 亚洲精品一线二线三线无人区| 欧美大屁股xxxxhd黑色| 天天躁日日躁狠狠久久| 无码人妻一区二区三区免费n鬼逝 好爽好湿好硬好大免费视频 | 少妇愉情理伦片丰满丰满午夜| 老湿机国产福利视频| 超碰成人人人做人人爽| 天天摸天天做天天爽| 99精品国产99久久久久久97| 97人人添人澡人人爽超碰| 免费无码国产欧美久久18| 在线天堂中文在线资源网| 国产99在线 | 免费| 久久国产欧美成人网站| 精品丰满人妻无套内射| 国产精久久一区二区三区| 午夜免费无码福利视频| 亚洲国产a∨无码中文777|