在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RLBP1 Antibody, FITC conjugated

RLBP1 Antibody, FITC conjugated

  • 中文名稱：
    RLBP1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA019743LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RLBP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RLBP1
  • 別名：
    Cellular retinaldehyde binding protein 1 antibody; Cellular retinaldehyde binding protein antibody; Cellular retinaldehyde-binding protein antibody; MGC3663 antibody; Retinaldehyde binding protein 1 antibody; Retinaldehyde-binding protein 1 antibody; RLBP 1 antibody; RLBP1 antibody; RLBP1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Retinaldehyde-binding protein 1 protein (10-91AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
  • 基因功能參考文獻(xiàn)：
    1. RLBP1 gene geographical area-related mutation is associated with retinitis punctata albescens. PMID: 28764803
    2. we provide evidence for an allosteric modulation of the enzymatic activity by 11-cis retinoids. This regulation is independent from cellular retinaldehyde-binding protein (CRALBP), the major cis-retinoid binding protein. PMID: 28096191
    3. These results show that joint tests of main effects and gene-gene interaction reveal associations at some novel loci that were missed when considering main effects alone. PMID: 28813576
    4. Different mutations in RLBP1 are correlated with quite different morphological and functional characteristics outlines the complexity of the protein. PMID: 25429852
    5. RLBP1 gene is upregulated in patients with reactive retinal astrocytic tumors. PMID: 24921169
    6. Patients with retinitis punctata albescens (RPA) show variable degrees of foveal cone death, even at an early stage. This finding has implications for future treatment. PMID: 23929416
    7. The two RLBP1 genotypes presented a phenotypical and electrophysiological expression of progressive retinal disease similar to that previously described in homozygotes for the c.700C>T (p.R234W) RLBP1 mutation. PMID: 22551409
    8. The clinical characteristics of a Japanese patient with a homozygous R234W mutation in RLBP1 are very similar to that of Swedish patients with Bothnia dystrophy. PMID: 22171637
    9. Identification of autoantibodies specific for two retinal antigens (CRALBP and S-Ag) supports the concept of an autoimmunological origin of the disease. PMID: 21904838
    10. The R234W mutation reveals impaired 11-cis-retinal release through stabilization of the ligand complex. PMID: 22183382
    11. mutations in RLBP1 are responsible for fundus albipunctatus in the affected individuals of these consanguineous Pakistani families. PMID: 21447491
    12. In the RLBP1-Bothnia dystrophy phenotype, a loss of function and thinning of the central macula are found, indicating early damage of the cone photoreceptors in this disease of the visual cycle. PMID: 20696998
    13. Newfoundland rod-cone dystrophy, an early-onset retinal dystrophy, is caused by splice-junction mutations in RLBP1 PMID: 11868161
    14. the M225K mutation abolishes and the R233W mutation tightens retinoid binding and both impair CRALBP function in the visual cycle as an 11-cis-retinol acceptor and as a substrate carrier. PMID: 12536144
    15. Trp-165, Met-208, Met-222, Met-225, and Trp-244 are components of the CRALBP ligand binding cavity. PMID: 12536149
    16. Patients with a clinical presentation of RPA (retinitis punctata albescens) can have genetically different mutations. PMID: 14718298
    17. Only eight RLBP1 mutations have been reported to date, and here we describe two novel mutations. PMID: 15234312
    18. Cellular retinaldehyde binding protein 1 (CRALBP) inhibits the reduction of 11-cis-retinal stronger than the oxidation of 11-cis-retinol, in accord with its higher affinity for 11-cis-retinal. PMID: 15865448
    19. A novel mutation in RLBP1 gene was found in a Japanese patient with retinitis punctata albescens. Degenerative changes of the outer retina were detected by optical coherence tomography PMID: 15953459
    20. Because of the high density of Alu elements in RLBP1, a systematic search should be made for deletions in this gene when one or both alleles lack point mutations, in the case of RPA or flecked retinal dystrophy. PMID: 17065479
    21. analysis of CRALBP ligand and protein interactions PMID: 17249612
    22. CRALBP transcripts in retinal pigment epithelium cells contain a noncoding exon in addition to a newly described promoter and, by definition, an additional intron PMID: 17652763
    23. The presence of CRALBP autoantibodies in 54% of tested uveitis patients supports CRALBP as a possible autoantigen in human autoimmune uveitis PMID: 18317528
    24. Bothnia dystrophy is caused by the loss of CRALBP function due to changed physical features and impaired activity of retinoid binding. PMID: 18344446
    25. These results reveal an unanticipated domino-like structural transition causing Bothnia-type retinal dystrophy by the impaired release of 11-cis-retinal from R234W. PMID: 19846785
    26. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Bothnia retinal dystrophy (BRD); Rod-cone dystrophy Newfoundland (NFRCD); Retinitis punctata albescens (RPA)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 組織特異性：
    Retina and pineal gland. Not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10024

    OMIM: 136880

    KEGG: hsa:6017

    STRING: 9606.ENSP00000268125

    UniGene: Hs.1933



主站蜘蛛池模板： 成人无码av一区二区三区| 疯狂做受xxxx高潮不断| 亚洲狠狠婷婷综合久久| 久久久亚洲精华液精华液精华液| 亚洲国内精品自在线影院| 少妇高潮惨叫久久久久电影| 国产在线观看www污污污| 国产av一区二区三区最新精品 | 天堂网在线.www天堂在线资源| 免费男人下部进女人下部视频| 蜜臀av在线无码国产| 亚洲欧洲美洲在线观看| 欧美激情a∨在线视频播放| 亚洲欧洲美洲无码精品va| 色一情一乱一伦一区二区三区小说 | 18禁在线永久免费观看 | 性做久久久久久免费观看| 久久亚洲精品无码播放| 午夜福利视频极品国产83| 国产又色又刺激高潮视频| 熟妇人妻中文字幕| 日日噜噜夜夜狠狠久久丁香五月| 欧美乱妇xxxxxbbbbb| 国产精品扒开腿做爽爽爽a片唱戏 久久99国产精品久久99 | 少妇极品熟妇人妻200片| 无码h肉动漫在线观看| 国产成人综合久久久久久| 老司机性色福利精品视频| 亚洲全部无码中文字幕| 人人妻人人澡人人爽| 亚洲精品国产嫩草在线观看东京热 | 色欲久久综合亚洲精品蜜桃| 欧美在线精彩视频免费播放| 少妇无码av无码专区在线观看| 在线 无码 中文字幕 强 乱 | 337p日本欧洲亚洲大胆69影院| 亚洲日韩国产av无码无码精品 | 呦系列视频一区二区三区| 性色av无码中文av有码vr| 免费无码av片流白浆在线观看| 久久狠狠高潮亚洲精品|