在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RIT1 Antibody, HRP conjugated

  • 中文名稱:
    RIT1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA846116LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RIT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GTP binding protein Roc1 antibody; GTP-binding protein Rit1 antibody; NS8 antibody; Ras like protein expressed in many tissues antibody; Ras like without CAAX 1 antibody; Ras-like protein expressed in many tissues antibody; Ras-like without CAAX protein 1 antibody; RIBB antibody; Ric like expressed in many tissues antibody; Ric-like protein without CAAX motif 1 antibody; RIT antibody; RIT1 antibody; RIT1_HUMAN antibody; ROC1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human GTP-binding protein Rit1 protein (1-219AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.
  • 基因功能參考文獻:
    1. The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. PMID: 29402968
    2. Our report contributes to the delineation of the phenotype associated with RIT1 mutations and underlines that lymphatic involvement is part of this spectrum PMID: 27109146
    3. RIT1 is one of the major genes for NS. The RIT1-associated phenotype differs gradually from other NS subtypes, with a high prevalence of cardiovascular manifestations, especially hypertrophic cardiomyopathy. PMID: 27101134
    4. Congenital left main coronary artery atresia in a Noonan syndrome is associated with RIT1 variant, leading to unrescued sudden death. PMID: 28347726
    5. Noonan patients with germline RIT1 mutations are not at high risk to developing JMML or ALL, and that RIT1 has at most a marginal role in these sporadic malignancies. PMID: 26757980
    6. Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1). PMID: 27226556
    7. We report on a 2.5-year-old male patient with clinical signs of NS and hematologic abnormalities, in whom a novel heterozygous substitution in RIT1 with probable pathogenicity was detected. PMID: 26518681
    8. Mutations in RIT1 cause Noonan syndrome. Mutations in RIT1 affect RAS-MAPK/MEK-ERK signaling. The mutant RIT1 protein may possess reduced GTPase activity or a diminished ability to interact with cellular GTPase activating proteins. PMID: 25959749
    9. elevated expression of RIT1 may contribute to the progression of endometrial cancer and thus may serve as a novel prognostic marker and a promising molecular target for the treatment of endometrial cancer. PMID: 26617739
    10. Because of the relatively high frequency of mutations in RIT1 among patients with NS and its occurrence in different populations, we suggest that it should be added to the list of genes included in panels for the molecular diagnosis of NS. PMID: 25124994
    11. A genotype-phenotype correlation analysis of available records indicated that germline RIT1 mutations cause a noonan syndrome phenotype characterized by a mild facial appearance. PMID: 26714497
    12. four additional cases of Noonan syndrome with mutations in RIT1, were identified. PMID: 24939608
    13. Data identify RIT1 as a driver oncogene in a specific subset of lung adenocarcinomas. PMID: 24469055
    14. we highlight recent studies using transgenic and knockout animal models which have begun to elucidate the physiological roles for the Rit subfamily, including emerging roles in the regulation of neuronal morphology and cellular survival signaling PMID: 23770287
    15. ROC1 knockdown remarkably inhibited bladder cancer cell growth, arrested cells at the G2 phase of the cell cycle, and induced the p53-dependent cell senescence. PMID: 23667514
    16. study demonstrates that RIT1 abnormalities, including activating mutations and locus amplifications, are novel lesions in a subgroup of patients with myeloid neoplasms, particularly frequent in chronic myelomonocytic leukemia PMID: 23765226
    17. Five RIT1 alterations identified in children with Noonan syndrome enhanced ELK1 transactivation. PMID: 23791108
    18. the present studies identify a critical role for the Rit-p38 MAPK signaling cascade in promoting hippocampal neuron survival following oxidative stress PMID: 23123784
    19. the Rit-p38-MSK1/2 signaling pathway may have an important role in the stress-dependent regulation of CREB-dependent gene expression. PMID: 23038261
    20. the studies establish Rit as a central regulator of a p38 MAPK-dependent signaling cascade that functions as a critical cellular survival mechanism in response to stress PMID: 21444726
    21. Rit plays a key role in human neuronal development and regeneration through activating both known and as yet undefined signaling pathways PMID: 12668729
    22. Gene amplification is one of the main activating ways of RIT1 gene in hepatocellular carcinoma (HCC), and its amplification might be correlated with HCC carcinogenesis, while point mutation might be not. PMID: 14767908

    顯示更多

    收起更多

  • 相關疾病:
    Noonan syndrome 8 (NS8)
  • 亞細胞定位:
    Cell membrane.
  • 蛋白家族:
    Small GTPase superfamily, Ras family
  • 組織特異性:
    Expressed in many tissues.
  • 數據庫鏈接:

    HGNC: 10023

    OMIM: 609591

    KEGG: hsa:6016

    STRING: 9606.ENSP00000357306

    UniGene: Hs.491234



主站蜘蛛池模板: 亚洲乱码精品久久久久..| 国产丝袜美女| 欧美人妻日韩精品| 色资源av中文无码先锋| 亚洲一码二码三码精华液| av无码中出一区二区三区| 欧美又粗又大aaa片| 国产精品va在线观看无码| 女同亚洲一区二区无线码| 亚洲欧美不卡高清在线观看| 96国产xxxx免费视频| 欧美激情日韩精品久久久| 亚洲高清有码中文字| 亚洲高清国产拍精品26u| 欧洲成人午夜精品无码区久久| 人人妻人人澡人人爽人人dvd| 国产成人亚洲精品无码蜜芽| 人妻性奴波多野结衣无码| 99国产精品久久久久久久成人热| 精品人妻少妇一区二区三区在线| 成 人 亚洲 综合天堂| 国产制服丝袜欧美在线观看| 欧美乱妇高清无乱码| 图片区小说区激情区偷拍区| 97色成人综合网站| 国产偷窥熟女精品视频| 中国国语毛片免费观看视频| 色综合 图片区 小说区| 欲色欲色天天天www| 日韩av无码中文无码不卡电影| 久久综合给合久久狠狠狠97色69 | 熟妇人妻中文av无码| 国产人妻大战黑人第1集| 久久精品一本到东京热| 日日噜噜夜夜爽爽| 中国xxxx做受视频| 久久精品日日躁夜夜躁| 成人无码视频| 老妇高潮潮喷到猛进猛出| 久久人人爽人人爽爽久久小说| 亚洲熟妇丰满多毛xxxx|