在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RIPK2 Antibody, Biotin conjugated

  • 中文名稱:
    RIPK2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA019736LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RIPK2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CARD 3 antibody; CARD carrying kinase antibody; CARD containing ICE associated kinase antibody; CARD containing IL 1 beta ICE kinase antibody; CARD containing IL1 beta ICE kinase antibody; CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody; CARD containing interleukin 1 beta converting enzyme associated kinase antibody; CARD-containing IL-1 beta ICE-kinase antibody; CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody; CARD3 antibody; CARDIAK antibody; CCK antibody; CLARP kinase antibody; GIG 30 antibody; GIG30 antibody; Growth inhibiting gene 30 antibody; Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody; Receptor interacting protein 2 antibody; Receptor interacting serine threonine kinase 2 antibody; Receptor interacting serine/threonine protein kinase 2 antibody; Receptor-interacting protein 2 antibody; Receptor-interacting serine/threonine-protein kinase 2 antibody; RICK antibody; RIP 2 antibody; RIP like interacting CLARP kinase antibody; RIP-2 antibody; RIP-like-interacting CLARP kinase antibody; RIPK 2 antibody; Ripk2 antibody; RIPK2_HUMAN antibody; TNFRSF antibody; Tyrosine-protein kinase RIPK2 antibody; UNQ277/PRO314/PRO34092 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Receptor-interacting serine/threonine-protein kinase 2 protein (1-540AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling.
  • 基因功能參考文獻:
    1. Two Single-Nucleotide Polymorphisms associated with susceptibility to develop dengue in NOD1 or RIPK2 genes were observed Children from Colombia. PMID: 30332343
    2. Nine compounds from the ZINC database show satisfactory results, yielding among those selected, the compound ZINC01540228, as the most promising RIPK2 inhibitor. After binding free energy calculations, the following molecular dynamics simulations showed that the receptor protein's backbone remained stable after the introduction of ligands. PMID: 30088101
    3. Results showed that the expressions of RIP2 and BclxL were positively correlated with the malignant grade of astrocytoma. RIP2 promoted human glioblastoma cell proliferation by inducing expression of BclxL. PMID: 29693188
    4. Together, these data show that RIP2 promotes survival of breast cancer cells through NF-kappaB activation and that targeting RIP2 may be therapeutically beneficial for treatment of TNBC. PMID: 29421659
    5. RIP2 kinase auto-phosphorylation is intimately coupled to dimerization. PMID: 28545134
    6. study provides structural and dynamic insights into the NOD1-RIP2 oligomer formation, which will be crucial in understanding the molecular basis of NOD1-mediated CARD-CARD interaction in higher and lower eukaryotes PMID: 28114344
    7. a new function of PAX5 in regulating RIP1 and RIP2 activation, which is at least involved in chemotherapeutic drug resistance in B-lymphoproliferative disorders, is reported. PMID: 27122187
    8. this study reveals that LRRK2 is a new positive regulator of Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway. PMID: 27830463
    9. Data indicate that receptor-interacting protein 2 (Rip2) polymorphisms are associated with increased risk of subclinical atherosclerosis (SA) and with some clinical and metabolic parameters. PMID: 27939575
    10. Together, the data demonstrate that the NOD2-RIP2 pathway is activated in murine and human visceral leishmaniasis and plays a role in shaping adaptive immunity toward a Th1 profile. PMID: 27651416
    11. RIP2 and RhoGDI bind to p75(NTR) death domain at partially overlapping epitopes with over 100-fold difference in affinity, revealing the mechanism by which RIP2 recruitment displaces RhoGDI upon ligand binding. PMID: 26646181
    12. that Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia PMID: 26130752
    13. up-regulated in failing hearts PMID: 26463597
    14. NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6. PMID: 24670424
    15. RIP2 protein, human is involved in human colon tumorigenesis and could be a predictive marker for colon carcinoma progression PMID: 25374171
    16. Data indicate that receptor-interacting protein kinase 2 (RIP2) is an activator of the NF-kappa B and c-Jun N-terminal kinase pathways. PMID: 24642040
    17. NOD1 and RIP2 interact with bacterial peptidoglycan on endosomes to promote autophagy and inflammatory signaling. PMID: 24746552
    18. the NOD1-RIP2 signaling axis is more complex than previously assumed, that simple engagement of RIP2 is insufficient to mediate signaling PMID: 24958724
    19. Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death. PMID: 24658576
    20. The Nod1/2-Rip2 axis was critical to induce optimal cytokine and chemokine responses to A. baumannii infection. PMID: 24366254
    21. LRRK2 and RIPK2 variants in the NOD 2-mediated signaling pathway are associated with susceptibility to Mycobacterium leprae in Indian populations. PMID: 24015287
    22. Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation. PMID: 23892723
    23. In an attempt to explore TRAF3 binding partners that may be involved in TRAF3-regulated signaling, a yeast two-hybrid screen of a human spleen cDNA library was undertaken. RIP2 was identified as a TRAF3 binding partner. PMID: 23333941
    24. inositol phosphatase SHIP-1 inhibits NOD2-induced NF-kappaB activation by disturbing the interaction of XIAP with RIP2 PMID: 22815893
    25. RIPK2 might play an important role in hepatic cell migration. These findings could shed new light on carcinogenesis and on liver regeneration. PMID: 22993319
    26. Association has been found between RIPK2 (rs42490) and cancer risk. PMID: 22504414
    27. regulates reduced prostaglandin E2 production in chronic periodontitis PMID: 22828789
    28. RIP2 tyrosine kinase activity is not only required for NOD2-dependent autophagy but plays a dual role in this process. PMID: 22665475
    29. These findings mechanisms whereby HBeAg modulates intracellular signaling pathways by targeting RIPK2, supporting the concept that HBeAg could impair both innate and adaptive immune responses to promote chronic HBV infection. PMID: 22615316
    30. IL-4 failed to up-regulate expression of RP105 at the cell surface. In conclusion, the anti-inflammatory actions of IL-4 occur independently of IL-10, RP105, and the kinase activity of RIPK2 PMID: 22484241
    31. RIP2 gene polymorphisms may be associated with susceptibility to systemic lupus erythematosus in the Chinese population. PMID: 22075569
    32. GEF-H1 mediated the activation of Rip2 during signaling by NOD2, but not in the presence of the 3020insC variant of NOD2 associated with Crohn's disease. GEF-H1 functioned downstream of NOD2 as part of Rip2-containing signaling complexes. PMID: 21887730
    33. the CARD of procaspase-1 is differently involved in the formation of procaspase-1 activating platforms and procaspase-1-mediated, RIP2-dependent NF-kappaB activation. PMID: 21862576
    34. Tri-DAP interacts directly with the LRR domain of NOD1 and consequently increases RICK/NOD1 association and RICK phosphorylation activity PMID: 21757725
    35. RIP2 polymorphisms are not associated with inflammatory bowel diseases. PMID: 20645315
    36. RIP2 undergoes autophosphorylation on Tyr 474 and this event is necessary for effective NOD2 signaling PMID: 21123652
    37. MS80 inhibits CD40-NF-kappaB pathway via targeting RIP2. PMID: 19911254
    38. detected on all female reproductive tract tissues PMID: 19406482
    39. Data suggest that inhibition of rip2 upregulation after wounding might contribute to the reduced and delayed wound re-epithelialization phenotype seen in glucocorticoid-treated patients. PMID: 20025869
    40. Elevated RIP-2 protein levels promote NF-kappaB function via interaction with IKK gamma PMID: 19693652
    41. the NOD2/RIP2 pathway has a role in recognition of Yersinia, but caspase-12 does not modulate innate host defense against Y. pestis PMID: 19721713
    42. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses PMID: 11894097
    43. These results implicate RIP2 in a previously unrecognized role: a checkpoint for myogenic proliferation and differentiation. PMID: 12138198
    44. equilibrium and kinetic folding of a unique protein domain, caspase recruitment domain (CARD), of the RIP-like interacting CLARP kinase (RICK) (RICK-CARD), which adopts a alpha-helical Greek key fold PMID: 12755636
    45. role in CARD6 modulation of NF-kappa B activation PMID: 12775719
    46. Rip2 has an important role in TCR-induced NF-kappaB activation and T-cell function PMID: 14638696
    47. NOD2-dependent ubiquitinylation of NEMO (a key component of the NF-kB signaling complex) is dependent on the scaffolding protein kinase RIP2. PMID: 15620648
    48. Caspase-1-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop; alterations of this balance may contribute to aberrant caspase-1-mediated pathogenesis in Huntington's disease. PMID: 16354923
    49. CARD6 is a regulator of NF-kappaB activation that modulates the functions of RICK protein PMID: 16418290
    50. NOD2-S interacts with both, NOD2 and receptor-interacting protein kinase 2 and inhibits the "nodosome" assembly by interfering with the oligomerization of NOD2 PMID: 16492792

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family
  • 組織特異性:
    Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
  • 數據庫鏈接:

    HGNC: 10020

    OMIM: 603455

    KEGG: hsa:8767

    STRING: 9606.ENSP00000220751

    UniGene: Hs.103755



主站蜘蛛池模板: 中文字幕v亚洲ⅴv天堂| 久久精品亚洲综合专区| 影视先锋男人无码在线| 无码成a毛片免费| 少妇被黑人到高潮喷出白浆| 老司机久久99久久精品播放| 老司机性色福利精品视频| 国产专区免费资源网站| 亚洲五月天综合| 亚洲熟妇无码乱子av电影| 三级做a全过程在线观看| 亚洲人成77777在线播放网站| 国产精品vr虚拟专区| 无码av永久免费专区麻豆| 久久久www成人免费无遮挡大片 | 先锋影音av资源站av| 中文字幕亚洲码在线观看| 无码福利日韩神码福利片| 国产草莓精品国产av片国产| 日韩内射美女片在线观看网站| 性xxxx欧美老妇胖老太性多毛| 免费精品国产人妻国语| 真人做人试看60分钟免费视频| 国产在线第一区二区三区| 131mm少妇做爰视频| 久久无码人妻精品一区二区三区| 中国熟妇浓毛hdsex| 国产男女猛烈视频在线观看| 一区一区三区产品乱码| 福利一区二区三区视频在线观看| 狠狠色丁香婷婷综合| 伊人久久大香线蕉综合bd高清| 中国china露脸自拍性hd| 精品国产一区二区三区四区阿崩| 西西人体扒开下部试看120秒| 国产成年码av片在线观看| 中字幕视频在线永久在线观看免费| 一边添奶一边添p好爽视频| 国产末成年av在线播放| 国产av无码专区影视| 欧美日本国产va高清cabal|