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RINT1 Antibody, HRP conjugated

  • 中文名稱:
    RINT1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA747351LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RINT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RINT1
  • 別名:
    DKFZp667H2324 antibody; FLJ11785 antibody; HsRINT 1 antibody; HsRINT-1 antibody; HsRINT1 antibody; RAD50 interacting protein 1 antibody; RAD50 interactor 1 antibody; RAD50-interacting protein 1 antibody; RINT 1 antibody; RINT-1 antibody; RINT1 antibody; RINT1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human RAD50-interacting protein 1 protein (401-700AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
  • 基因功能參考文獻:
    1. Study presents evidence that in the Caucasian population, RINT1 does not represent a moderate- penetrance breast cancer susceptibility gene, and find no evidence to support an association of RINT1 mutation with Lynch syndrome-related cancer incidence in breast cancer families. PMID: 27544226
    2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer. PMID: 28264000
    3. HPV E2 protein targets Rad50-interacting protein 1 (Rint1) to facilitate virus genome replication. PMID: 28031358
    4. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. PMID: 27530925
    5. Results suggest that high RAD50 interactor 1 (RINT1) expression may represent a risk factor for low-grade gliomas (LGGs)-related seizures. PMID: 25304616
    6. Results identified RINT1 as a putative breast cancer predisposition gene that also seems to be associated with risk for a spectrum of other cancers similar to those that have previously been described for Lynch syndrome. PMID: 25050558
    7. RINT-1 is also required for endosome-to-trans-Golgi network trafficking. PMID: 23885118
    8. RINT1 was validated as a novel glioblastoma oncogene PMID: 23074196
    9. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division. PMID: 17470549
    10. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596

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  • 亞細胞定位:
    Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族:
    RINT1 family
  • 數據庫鏈接:

    HGNC: 21876

    OMIM: 610089

    KEGG: hsa:60561

    STRING: 9606.ENSP00000257700

    UniGene: Hs.531388



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