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  4. RIN3 Antibody

RIN3 Antibody

  • 中文名稱：
    RIN3兔多克隆抗體
  • 貨號：
    CSB-PA004010
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using RIN3 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RIN3
  • 別名：
    RIN3 antibody; Ras and Rab interactor 3 antibody; Ras interaction/interference protein 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RIN3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
  • 基因功能參考文獻：
    1. RIN3 may be involved in endolysosomal transport-a process known to be important to development of early onset AD. PMID: 28738127
    2. RIN3 may contribute to Paget's disease of bone susceptibility by affecting osteoclast function. PMID: 25701875
    3. discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3 PMID: 26296892
    4. The study reports a novel association between a variant within RIN3 and lower limb-bone mineral density and note its previous association with risk of Paget's disease. PMID: 24945404
    5. RIN3 is a negative regulator of mast cell responses to SCF PMID: 23185384
    6. RIN3 specifically acts as a GEF for Rab31. PMID: 21586568
    7. RIN3 biochemically characterized as the stimulator and stabilizer for GTP-Rab5 plays an important role in the transport pathway from plasma membrane to early endosomes PMID: 12972505
    8. Tyrosine-phosphorylation signals are involved in the RIN3 activation and translocation to early endocytic vesicles. PMID: 18486601

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  • 亞細胞定位：
    Cytoplasm. Cytoplasmic vesicle. Early endosome.
  • 蛋白家族：
    RIN (Ras interaction/interference) family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 18751

    OMIM: 610223

    KEGG: hsa:79890

    STRING: 9606.ENSP00000216487

    UniGene: Hs.326822



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