在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RHOU Antibody

  • 中文名稱:
    RHOU兔多克隆抗體
  • 貨號:
    CSB-PA987503
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse stomach and human fetal muscle tissue, Primary antibody: CSB-PA987503(RHOU Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RHOU
  • 別名:
    ARHU antibody; CDC42 L1 antibody; CDC42 like GTPase antibody; CDC42-like GTPase 1 antibody; CDC42L1 antibody; G28K antibody; GTP binding protein like 1 antibody; GTP binding protein SB128 antibody; GTP-binding protein-like 1 antibody; hG28K antibody; mG28K antibody; Ras homolog gene family member U antibody; Ras homolog gene family member U isoform CRA a antibody; Ras like gene family member U antibody; Rho GTPase like protein ARHU antibody; Rho GTPase-like protein ARHU antibody; Rho related GTP binding protein RhoU antibody; Rho-related GTP-binding protein RhoU antibody; Rhou antibody; RHOU_HUMAN antibody; Ryu GTPase antibody; Wnt-1 responsive Cdc42 homolog 1 antibody; Wnt1 responsive Cdc42 homolog antibody; WRCH 1 antibody; WRCH-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human RHOU
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
  • 基因功能參考文獻:
    1. These results unravel a role for RhoU not only in regulating the migratory features of malignant plasma cells, but also in controlling cell cycle progression. PMID: 29440639
    2. This review addresses the developmental roles of 2 GTPases of the Rho family, RhoV/Chp and RhoU/Wrch. PMID: 26555387
    3. PAK4 and RhoU cooperate to drive adhesion turnover and promote cell migration. PMID: 26598620
    4. Data indicate that upregulated miR-126 upon coxsackievirus B3 (CVB3) infection targets SPRED1, LRP6, and WRCH1 genes, mediating cross-talk between ERK1/2 and Wnt/beta-catenin pathways, and thus promoting viral replication. PMID: 23811937
    5. multiple upstream signals may converge on Wrch1 directly through its SH3 domain-binding properties PMID: 23183748
    6. results indicate that NOTCH1 mutation stimulates T-cell acute lymphoblastic leukaemia cell migration through RhoU upregulation that could contribute to the leukaemia cell dissemination PMID: 22349824
    7. data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio PMID: 21508312
    8. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. PMID: 21565175
    9. Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src. PMID: 20547754
    10. Down regulation of WRCH1 by estradiol in breast cancer and altered expression of WRCH1 is associated with other cancers PMID: 11894124
    11. G28K cDNA encodes a protein of 258 amino acids with homology to the cell division cycle 42/G25K protein; this gene is located at 1q42.11-q42.3; G28K was abundantly expressed in the stomach and the small intestine PMID: 14731133
    12. These data suggest that Wrch-1 regulates cell migration by multiple mechanisms: on the one hand Wrch-1 controls focal adhesions by regulating myosin light chain and on the other hand Wrch-1 stimulates the activation of Akt and JNK. PMID: 17504809
    13. Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of tight junction and actin organization. PMID: 19064640
    14. As an essential actor of osteoclast differentiation, the atypical RhoGTPase Wrch1/RhoU could be an interesting target for the development of novel antiresorptive drugs. PMID: 19135548

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome.
  • 蛋白家族:
    Small GTPase superfamily, Rho family
  • 組織特異性:
    Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
  • 數據庫鏈接:

    HGNC: 17794

    OMIM: 606366

    KEGG: hsa:58480

    STRING: 9606.ENSP00000355652

    UniGene: Hs.647774



主站蜘蛛池模板: 凹凸国产熟女精品视频| av天堂午夜精品一区| 亚洲精品456在线播放| 国产成人久久a免费观看| 久久久久久国产精品mv| 国产女人高潮抽搐喷水视频| 中国极品少妇xxxxx| 欧美精品乱码99久久蜜桃| 天天爽亚洲中文字幕| 国产美女精品视频线免费播放软件| 女人被强╳到高潮喷水在线观看| 蜜桃视频网站| 成人午夜电影福利免费| 成在人线无码aⅴ免费视频| 日韩精品一区二区三区视频 | 久久久久国产精品熟女影院| 老太婆性杂交欧美肥老太| 国产成+人+综合+亚洲欧美丁香花| 无码人妻久久1区2区3区| av片在线播放| 西西人体www大胆高清| 呻吟国产av久久一区二区| 最近中文字幕mv在线视频看| 天天狠天天透天干天天怕∴| 亚洲精品久久久久久下一站| 四虎永久在线精品免费观看视频| 色在线亚洲视频www| 国产精品水嫩水嫩| 无码专区 人妻系列 在线| 又黄又爽又色的免费网站| 日韩精品射精管理在线观看| 日本肥老妇色xxxxx日本老妇| 蜜桃av久久久一区二区三区麻豆| 欧美黑人巨大xxxxx视频| 国产国拍亚洲精品av在线| 亚洲乱亚洲乱妇24p| 国产精品美女久久久m| 无码国产成人午夜电影在线观看 | 亚洲 欧美精品suv| 综合亚洲另类欧美久久成人精品| 欧美性xxxxx极品少妇|