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  4. RHOBTB3 Antibody

RHOBTB3 Antibody

  • 中文名稱：
    RHOBTB3兔多克隆抗體
  • 貨號：
    CSB-PA008260
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using RHOBTB3 Polyclonal Antibody
    • Western blot analysis of customer's lysis using RHOBTB3 antibody.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RHOBTB3
  • 別名：
    RHOBTB3 antibody; KIAA0878 antibody; Rho-related BTB domain-containing protein 3 antibody; EC 3.6.1.- antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RHOBTB3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IHC 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.
  • 基因功能參考文獻：
    1. RHOBTB3 serves as a scaffold to organize a multi-subunit complex that promotes the hydroxylation, ubiquitination and degradation of HIFalpha. PMID: 26215701
    2. Reveal a novel role for a RhoBTB3 in catalyzing cyclin E turnover during S phase, as well as an unexpected, essential role for the Golgi as a ubiquitylation platform for cell cycle control. PMID: 24145166
    3. The interaction between RhoBTB3 and the 5-HT7a receptor strongly inhibits proteasomal degradation of the 5-HT7a receptor. PMID: 22245496
    4. Study reports that the atypical Rho GTPase family member, RhoBTB3, binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. PMID: 19490898
  • 亞細胞定位：
    Golgi apparatus.
  • 組織特異性：
    Ubiquitous. Highly expressed in neural and cardiac tissues, pancreas, placenta and testis.
  • 數據庫鏈接：

    HGNC: 18757

    OMIM: 607353

    KEGG: hsa:22836

    STRING: 9606.ENSP00000369318

    UniGene: Hs.445030



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