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  4. RHEBL1 Antibody, Biotin conjugated

RHEBL1 Antibody, Biotin conjugated

  • 中文名稱：
    RHEBL1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA855034LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RHEBL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RHEBL1
  • 別名：
    RHEBL1 antibody; GTPase RhebL1 antibody; Ras homolog enriched in brain like-1 c antibody; RhebL1c antibody; Ras homolog enriched in brain-like protein 1 antibody; Rheb-like protein 1 antibody; Rheb2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GTPase RhebL1 protein (1-180AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
  • 基因功能參考文獻(xiàn)：
    1. High RHEBL1 expression is associated with lung cancer. PMID: 28209923
    2. These results establish CAD as a downstream effector of Rheb and suggest a possible role of Rheb in regulating de novo pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) PMID: 25422319
    3. RhebL1 may be impacting the mTOR pathway in a different manner than Rheb1. PMID: 21655954
    4. Data show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal, and identify critical residues in Rheb and RhebL1 which are required for their efficient activation of mTOR signaling. PMID: 16098514
    5. RHEBL1 is a positive regulator of NF-kappa B-mediated gene transcription. PMID: 16328882

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  • 亞細(xì)胞定位：
    Endomembrane system; Lipid-anchor; Cytoplasmic side. Cytoplasm.
  • 蛋白家族：
    Small GTPase superfamily, Rheb family
  • 組織特異性：
    Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21166

    KEGG: hsa:121268

    STRING: 9606.ENSP00000301068

    UniGene: Hs.159013



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