在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RGS5 Antibody

  • 中文名稱:
    RGS5兔多克隆抗體
  • 貨號:
    CSB-PA782441
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA782441(RGS5 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RGS5
  • 別名:
    MST092 antibody; MST106 antibody; MST129 antibody; MSTP032 antibody; MSTP092 antibody; MSTP106 antibody; MSTP129 antibody; Regulator of G Protein Signalling 5 antibody; Regulator of G-protein signaling 5 antibody; RGS 5 antibody; RGS5 antibody; RGS5_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human RGS5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
  • 基因功能參考文獻:
    1. The chimeric RGS8 domains containing the first or the second exon part of RGS5 showed strong inhibitory effects similar to that of wild type RGS8, but the chimeric domain with the third exon part of RGS5 lost its activity PMID: 26754208
    2. Rgs5 prevents vagal-related bradycardia and atrial tachycardia by negatively regulating the IKA Ach current. PMID: 26961238
    3. The rs16849802 of RGS5 and haplotype GAA independently increased the risk of essential hypertension in Mongolian patients, and may be used as a risk factor for the prediction of high blood pressure. PMID: 26782409
    4. Downregulation of RGS5 is an important prerequisite for smooth muscle cell proliferation in vascular injury model. PMID: 26663397
    5. The pericyte marker RGS5 may be of future clinical utility for the evaluation of pericytic differentiation in soft tissue tumors. PMID: 26558691
    6. RGS5 enhanced the cytotoxic effect of radiation in the human lung cancer cells. Our results indicated that RGS5 may be a potential target for cancer therapy. PMID: 25891540
    7. Our work identifies a new genetic variant in RGS5 demonstrating additive effect with PDE4D, both implicated in modulation of asthma treatment. PMID: 23193110
    8. ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected. PMID: 24297163
    9. RGS1 is largely upregulated, whereas RGS2 is downregulated in the majority of solid tumors, whereas RGS5 transcripts are greatly increased in eight subtypes of lymphoma with no reports of downregulation in hematological malignancies PMID: 23464602
    10. Over-expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma cells. PMID: 23868206
    11. demonstrate RGS5 in the blood vessels of other cancer models endowed with a proangiogenic environment, such as human melanoma and renal carcinoma xenografts PMID: 22130514
    12. Low expression of RGS5 was strongly associated with cancer vasculature invasion and lymph node metastasis in non-small cell lung cancer. PMID: 21780128
    13. examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans PMID: 21881522
    14. regulator of G-protein signaling 5 can act as a physiological regulator of calcium sensing by calcium sensing receptor in the parathyroid gland PMID: 21393447
    15. Repetitive beta(2)-agonist use may not only lead to reduced bronchoprotection but also to sensitization of excitation-contraction signaling pathways as a result of reduced RGS5 expression PMID: 21278382
    16. RGS5 expression level in gastric carcinoma is associated with the differentiation and microvascular density of the tumor, and may be used as an important parameter for determining the prognosis of gastric carcinoma patients. PMID: 21105200
    17. used transgenic mice show that the cardiac constitutive expression of human Rgs5 protects against cardiac hypertrophy and fibrosis by blocking MEK-ERK1/2 signaling, whereas Rgs5-/- mice displayed the opposite phenotype. PMID: 20643937
    18. Multiple SNPs in combination in RGS5 may confer risk for hypertension. Our results also lend support for the effect of RGS5 SNPs on lipid metabolism PMID: 19863299
    19. There is a contribution of RGS5 to schizophrenia susceptibility. PMID: 14755443
    20. Elevated levels of RGS-5 in pericytes are also observed during wound healing and ovulation indicating a strong correlation between RGS-5 expression and active vessel remodeling. PMID: 15459006
    21. The loss of RGS5 in the fibrous cap is of particular interest because of its role in vessel development and physiology and loss in fibrous cap of atherosclerosis PMID: 16293795
    22. x-ray crystallography of the complex of RGS5 and Galphai(3) proteins with GDP/Mg(2+)/AlF(4)(-) at 3.0 A resolution PMID: 17100651
    23. examined function, receptor specificity, and expression of R4 subfamily RGS proteins, RGS2, -3, -4, -5, and -8 via missense mutations introduced PMID: 17220356
    24. RGS5 dimerization was confirmed by the analysis of a GFP tagged RGS5 fusion in yeast and with two-hybrid assays PMID: 17762159
    25. Rgs5 and Notch3 are expressed in pericytes of developing and injured teeth and have roles along with vascular-derived stem cells during pulp healing PMID: 17939118
    26. RGS5 genotypes predicted severity of baseline symptoms in schizophrenia. These data suggest a possible role for multiple RGS proteins in schizophrenia. PMID: 18262772
    27. RGS5 is a novel HIF-1-dependent, hypoxia-induced gene that is involved in the induction of endothelial apoptosis. PMID: 19564336

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cytoplasm. Membrane.; [Isoform 2]: Cytoplasm.
  • 數據庫鏈接:

    HGNC: 10001

    OMIM: 603276

    KEGG: hsa:8490

    STRING: 9606.ENSP00000319308

    UniGene: Hs.24950



主站蜘蛛池模板: 日本丰满少妇高潮呻吟| 中文毛片无遮挡高潮免费| 伦伦影院午夜理论片| 免费男人下部进女人下部视频| 欧美嫩交一区二区三区| 国产av无码专区亚洲aⅴ| 色欲国产麻豆一精品一av一免费 | 欧美一区二区三区啪啪| 很色很爽很黄裸乳视频| 欧美人与动zozo在线播放| 免费床视频大全叫不停欧美| 在线a亚洲视频播放在线观看| 欧美老妇牲交videos| 激情综合婷婷丁香五月情| 国产亚洲综合欧美一区二区| 成人精品一区二区三区电影| 日韩av无码国产精品| 色悠久久久久综合先锋影音下载| 最近中文av字幕在线中文| 欧美激情一区二区| 国产美女嘘嘘嘘嘘嘘| 亚洲.日韩.欧美另类| 亚洲熟女少妇一区二区| 免费看成人欧美片爱潮app| 国产成人av国语在线观看| 久久99精品久久久久蜜芽| 精品久久久久久人妻无码中文字幕 | 最近中文字幕免费大全在线| 国产作爱激烈叫床视频| 欧美俄罗斯乱妇| 亚洲国产一卡2卡3卡4卡5公司| 真实国产乱子伦在线视频| 最爽爱爱高潮免费视频| 欲香欲色天天天综合和网| 亚洲人成77在线播放网站| 337p日本欧洲亚洲大胆在线| 97久久国产亚洲精品超碰热 | 啪啪激情婷婷久久婷婷色五月| 破了亲妺妺的处免费视频国产| 全球av集中精品导航福利| 亚洲成a人v在线蜜臀|