在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RFX1 Antibody, HRP conjugated

  • 中文名稱:
    RFX1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA019610LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RFX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RFX1
  • 別名:
    AI047719 antibody; AI385641 antibody; EF-C antibody; EFC antibody; Enhancer factor C antibody; MHC class II regulatory factor RFX antibody; MHC class II regulatory factor RFX1 antibody; Regulatory factor X 1 antibody; Regulatory factor X, 1 (influences HLA class II expression) antibody; Regulatory factor X1 antibody; RFX antibody; RFX-1 antibody; Rfx1 antibody; RFX1_HUMAN antibody; Trans-acting regulatory factor 1 antibody; Transcription factor RFX1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human MHC class II regulatory factor RFX1 protein (36-133AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.
  • 基因功能參考文獻:
    1. RFX1 interacts with the D sequence of adeno-associated virus inverted terminal repeat and regulates AAV transduction. PMID: 29317724
    2. RFX1 expression was significantly lower in HCC tissues compared to the corresponding non-tumor tissues. In vitro studies suggested that knocking down RFX1 facilitated HCC cell invasion, while overexpression of RFX1 reduced the invasion of HCC cells. RFX1 regulated expression of some epithelial-mesenchymal transition markers. PMID: 29764705
    3. Findings indicate that RFX1 functions downstream of STAT3 and phosphorylated STAT3 can inhibit RFX1 expression and suggest a unique role for RFX1 in Th17-related autoimmune diseases. PMID: 29422534
    4. Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR-124 regulation; identified the binding site through which RFX1 directly regulates ApoE, may explain the missing link between decreased miRNA-124 and ineffective Abeta uptaking during aging. PMID: 28003160
    5. induction of ciliogenesis increases the expression of RFX and dyslexia candidate genes PMID: 27451412
    6. Data show that transcription factor regulatory factor X 1 (RFX1) protein expression can be tightly regulated by polyubiquitination-mediated proteosomal degradation via STIP1 homology and U-box containing protein 1 (STUB1). PMID: 27283392
    7. therapeutic targets for childhood severe asthmatics identified thru DNA microarray PMID: 25979195
    8. Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells. PMID: 24952874
    9. regulatory factor 1 directly regulates CD44 expression in glioblastoma PMID: 24526308
    10. Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs. PMID: 22415835
    11. RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription. PMID: 22582395
    12. NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis-regulatory elements. PMID: 22490869
    13. RFX1 recruits SUV39H1 to the promoter regions of the CD11a and CD70 genes in CD4(+) T cells, thereby regulating local H3K9 tri-methylation levels. PMID: 21192791
    14. regulates autoimmunity via epigenetic modifications in T cells of systemic lupus erythematosus patients PMID: 20223637
    15. We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transc PMID: 20381594
    16. RFX1 may negatively regulate the self-renewal of GBM-SCs through modulating FGF-1B and FGF1 expression levels by binding the 18-bp cis-elements of the F1B promoter. PMID: 20189986
    17. Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells. PMID: 12411430
    18. Disruption of the RFX site within 263P blunts repressor activity in transfected GC cells; however, repression is only abolished when both PSE-A/RFX and PSE-B/NF-1 sites are mutated. PMID: 12624117
    19. novel role for the RFX family of transcription factors as modulators of Ras signalling in epithelial cells PMID: 15024578
    20. RFX1 gene may be epigenetically silenced in human gliomas and involved in glioma tumorigenesis. PMID: 15334059
    21. Six novel S'-Y' regulatory modules have been identified that are controlled by the human major histocompatibility class II-specific regulatory factor RFX complex. PMID: 15528357
    22. evidence for a common mechanism for Crt1 and Rfx1 expression and for the conservation of their mode of action in response to a DNA replication block in yeasts and humans PMID: 16287876
    23. The binding of alpha Adducin to RFX-I and their nuclear co-localization suggests that Adducin can have a role in modulating the transcriptional regulating activity of RFX-I. PMID: 16289097
    24. results demonstrate that RFX1 and RFX5 differentially interact with class I HDACs underlying the different pathways when repressing collagen synthesis PMID: 16464847
    25. RFX1 mediates the immediate early response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells. PMID: 17630394
    26. RFX1 specifically bind to promoter region and negatively regulate the transcription of the human PNRC gene. PMID: 19334528
    27. RFX and/or enhanceosome assembly plays a key role independent of transcriptional coactivator CIITA in protecting major histocompatibility class II antigen promoters against DNA methylation. PMID: 19620312

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    RFX family
  • 數據庫鏈接:

    HGNC: 9982

    OMIM: 600006

    KEGG: hsa:5989

    STRING: 9606.ENSP00000254325

    UniGene: Hs.655215



主站蜘蛛池模板: 特级毛片内射www无码| 无码午夜人妻一区二区不卡视频| 色在线亚洲视频www| 亚洲日韩乱码中文无码蜜桃臀| 日本妇人成熟免费| 亚洲精品无码av中文字幕电影网站| 伊人久久大香线蕉综合狠狠| 免费网站看sm调教视频| 好吊视频一区二区三区| 国产精品沙发午睡系列990531| 一二三四视频社区在线播放中国| 人人妻碰人人免费| 97精品超碰一区二区三区| 国产男女性潮高清免费网站| 国产成人免费无码av在线播放| 亚洲大片av毛片免费| 草的我好爽视频| 色妞色视频一区二区三区四区| 亚洲精品第一国产综合境外资源| 成人麻豆亚洲综合无码精品| 日本va在线视频播放| 成人欧美一区二区三区1314| 日夜啪啪一区二区三区| 亚洲色成人影院在线观看| 啦啦啦www在线观看免费视频| 亚洲欧美日韩中文久久| 女性自慰网站免费看ww| 免费看国产zzzwww色| 波多野结衣办公室双飞| 久久香蕉国产线看观看怡红院妓院| 九九热久久只有精品2| 国产乱码二卡3卡四卡| 久久精品国产免费观看| 天天综合天天做天天综合| 国产无夜激无码av毛片| 亚洲.日韩.欧美另类| 国产精品盗摄!偷窥盗摄| 久久精品国产一区二区三区| 国产成人精品一区二区三区免费看 | 男人和女人高潮免费网站| 亚洲香蕉网久久综合影视|