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  4. RFK Antibody, HRP conjugated

RFK Antibody, HRP conjugated

  • 中文名稱：
    RFK兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA836167LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RFK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RFK
  • 別名：
    0610038L10Rik antibody; AF031381 antibody; ATP:riboflavin 5' phosphotransferase antibody; ATP:riboflavin 5''-phosphotransferase antibody; Flavokinase antibody; FLJ11149 antibody; KOI 4 antibody; Rfk antibody; Riboflavin kinase antibody; RIFK antibody; RIFK_HUMAN antibody; RP11-422N19.2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Riboflavin kinase protein (1-154AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
  • 基因功能參考文獻：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that RFK is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. DR4 and DR5 have a capability to activate Nox1 by recruiting RFK, resulting in ROS-mediated apoptotic cell death in tumor cells. PMID: 22158615
    3. levels of riboflavin kinase expression correlate well with Gleason score, known as a good indicator of patient prognosis PMID: 21308351
    4. the structure of riboflavin kinase cocrystallized with both MgADP and FMN is reported; drastic conformational changes associated with flavin binding are observed primarily at the so-called Flap I and Flap II loop regions PMID: 14580199
    5. results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase PMID: 19641494

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  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Detected in brain, placenta and urinary bladder.
  • 數據庫鏈接：

    HGNC: 30324

    OMIM: 613010

    KEGG: hsa:55312

    STRING: 9606.ENSP00000365926

    UniGene: Hs.37558



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