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  4. REPS2 Antibody

REPS2 Antibody

  • 中文名稱：
    REPS2兔多克隆抗體
  • 貨號：
    CSB-PA019566GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    REPS2
  • 別名：
    REPS2 antibody; POB1 antibody; RalBP1-associated Eps domain-containing protein 2 antibody; Partner of RalBP1 antibody; RalBP1-interacting protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Human REPS2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway. By controlling growth factor receptors endocytosis may regulate cell survival. Through ASAP1 may regulate cell adhesion and migration.
  • 基因功能參考文獻：
    1. miR-675-5p might play an oncogenic role in esophageal squamous cell carcinoma (ESCC) through RalBP1/RAC1/CDC42 signaling pathway by inhibiting REPS2 and might serve as a valuable prognostic biomarker and therapeutic target for ESCC patients. PMID: 27120794
    2. downregulation of REPS2 may contribute to malignant progression of esophageal squamous cell carcinoma and represent a novel prognostic marker and a potential therapeutic target for esophageal squamous cell carcinoma patients. PMID: 23803043
    3. These results suggest that POB1 interacts with PAG2 through its proline-rich motif, thereby regulating cell migration. PMID: 12149250
    4. POB1, through its influence on the Ral signalling pathway, is involved in growth factor signalling and consequently in control of cell proliferation PMID: 12771942
    5. decreased expression of REPS2 might be a key factor, causing prostate cancer cells to become resistant to induction of apoptosis by androgen deprivation. PMID: 15184881
    6. Decreased REPS2 expression is associated with androgen-independent state of advanced prostate cancer PMID: 15455380
    7. These results show for the first time that POB1 can regulate the transport function of RLIP76 and are consistent with our previous studies showing that inhibition of RLIP76 induces apoptosis in cancer cells. PMID: 15707977
    8. Hsf-1 causes specific and saturable inhibition of the transport activity of Ralbp1 and that the combination of Hsf-1 and POB1 causes nearly complete inhibition through specific bindings with Ralbp1. PMID: 18474607
    9. REPS2 may be a useful tumor marker for favorable prognosis in breast cancer. PMID: 19776672

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  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Isoform 2 is down-regulated during progression of prostate cancer.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9963

    OMIM: 300317

    KEGG: hsa:9185

    STRING: 9606.ENSP00000349824

    UniGene: Hs.186810



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