在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RDX Antibody

  • 中文名稱:
    RDX兔多克隆抗體
  • 貨號:
    CSB-PA593723
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA593723(RDX Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA593723(RDX Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, human fetal brain tissue, Human hepatocellular carcinoma tissue, Primary antibody: CSB-PA593723(RDX Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CB567 antibody; CG12537 antibody; DFNB24 antibody; ESP10 antibody; Hh-induced MATH and BTB domain-containing protein antibody; HIB antibody; Moesin-B antibody; Protein roadkill antibody; RADI_HUMAN antibody; Radixin antibody; RDX antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human RDX
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
  • 基因功能參考文獻:
    1. CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family. PMID: 27793041
    2. The results reveal a supportive role of ERMs in cortical activities during cytokinesis, and also provide insight into the selective mechanism that preferentially associates cytokinesis-relevant proteins with the division site. PMID: 28889652
    3. Radixin knockdown suppresses the metastasis of SGC-7901 cells in vitro by up-regulation of E-cadherin. The NF-kappaB/snail pathway contributes to the regulation of E-cadherin in response to depletion of radixin. PMID: 27855404
    4. Phospho-Ezrin/Radixin/Moesin (ERM) inhibit cell adhesion, and therefore, dephosphorylation of ERM proteins is essential for cell adhesion.Phospho-ERM induce formation and/or maintenance of spherical cell shape. PMID: 26555866
    5. These studies identify Akt2 as a critical kinase that regulates radixin phosphorylation and leads to Mrp-2 translocation and function. PMID: 26500117
    6. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. PMID: 26209696
    7. High Radixin expression is associated with glioblastoma. PMID: 25520109
    8. Ezrin, radixin and moesin are unlikely targets for autoantibodies in demyelinating neuropathies. PMID: 25286001
    9. These data suggest an association between RDX polymorphisms and the clinical features of RA patients, particularly the ESR PMID: 24854655
    10. Radixin was identified as a target gene of miR-196a/-196b. Elevated miR-196a/-196b expression in GC cells led to reduced radixin protein levels and vice versa. PMID: 24933454
    11. This study finding have implications concerning the importance of concomitant radixin upregulation in tumor progression and poor prognosis of patients with gliomas. PMID: 24380686
    12. important role of ezrin-moesin-radixin proteins during HCV infection at the postentry level and highlight possible novel targets for HCV treatment. PMID: 23703860
    13. ERM proteins play important differential roles in the thrombin-induced modulation of EC permeability, with moesin promoting barrier dysfunction and radixin opposing it. PMID: 23729486
    14. Data suggest that P-glycoprotein associate with the F-actin cytoskeleton through ezrin/radixin/moesin (ERM) in CCR9/CCL25 induced multidrug resistance of acute T-lymphocytic leukemia (T-ALL) cells. PMID: 23326330
    15. Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling. PMID: 23116763
    16. Data show that silencing of radixin (RDX) phenocopied the effects of miR-409 overexpression, whereas restoration of RDX in miR-409-overexpressed gastric cancer (GC) cells reversed the suppressive effects of miR-409. PMID: 22179828
    17. Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein. PMID: 22891241
    18. results suggest that radixin might play a critical role in pancreatic cancer progression, possibly through involvement of down-regulation of TSP-1 and E-cadherin expression. PMID: 22631643
    19. role of CCM3 and ezrin/radixin/moesin family of proteins in cell's response to oxidative stress PMID: 22291017
    20. Ano1, ezrin, and moesin/radixin colocalize apically in salivary gland epithelial cells, and overexpression of moesin and Ano1 in HEK cells alters the subcellular localization of both proteins PMID: 22685202
    21. Radixin selectively modulates the expression and function of MRP2 in human gastric adenocarcinoma. PMID: 22469515
    22. MiR-31 targeted radixin predominantly via inhibition of protein translation instead of degradation of mRNA. PMID: 22089331
    23. results indicate that ezrin influences the expression of P-gp at the translational level, whereas radixin is involved in membrane localization of P-gp in HepG2 cells PMID: 21837648
    24. The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers. PMID: 22132106
    25. Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability. PMID: 21659656
    26. the ezrin, radixin and moesin proteins differentially modulate sphingosine 1 phosphate-induced alterations in lung endoethlial cell cytoskeleton and permeability PMID: 21864676
    27. This study provides the novel evidence that increased phosphorylation of Ezrin/radixin/moesin proteins may contribute to proliferation of rheumatoid fibroblast-like synoviocytes. PMID: 21278069
    28. Dysregulation of the ezrin/radixin/moesin-RAGE complex might be an important step in rearrangement of the actin cytoskeleton during proinflammatory cytokine-induced epithelial-mesenchymal transition of human alveolar epithelial cells. PMID: 21278261
    29. ezrin, radixin and moesin play similar roles in the tumor cell metastatic potential and their roles of upregulating the expression of E-cadherin may be important in tumor progression PMID: 21352885
    30. Polar distribution of radixin suggest a role in promoting formation and plasticity of membrane surface projections and also suggest that radixin is an organizer and regulator of Mrp-2 and cell polarity in hepatocytes. PMID: 21160029
    31. the identification of radixin as a scaffolding unit for both cAMP effectors, Epac and PKA PMID: 21047789
    32. Results demonstrate a new regulatory mechanism of ezrin-radixin-moesin phosphorylation by sphingolipids with opposing actions of ceramide and sphingosine 1-phosphate. PMID: 20679347
    33. Data suggest that ezrin-radixin-moesin proteins are involved in the spatial regulation of Epac1 and cooperate with cAMP- and Rap-mediated signaling to regulate adhesion to the extracellular matrix. PMID: 20855527
    34. amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products and have a role in diabetes PMID: 12734202
    35. Disrupted localization of radixin and MRP2 supports the concept that radixin contributes to the canalicular localization of MRP2. PMID: 14568249
    36. ezrin/radixin/moesin proteins are recruited by NHE1 Na+/H+ exchanger and have roles in regulating Akt-dependent cell survival PMID: 15096511
    37. All three ERM family members can localise to the nucleus; a specific nuclear localisation sequence, which is conserved and functional in all ERM family members, is identified, implying specific regulated nuclear import. PMID: 15149851
    38. results suggest that ezrin-radixin-moesin proteins are required for microvillar positioning of L-selectin and that this is important both for leukocyte tethering and L-selectin shedding PMID: 15178693
    39. Ezrin, radixin and moesin are ADP-ribosylated by Pseudomonas aeruginosa ExoS PMID: 15252013
    40. Conformational regulation of radixin protein function occurs by association of the FERM and C-terminal domains, whereby the membrane- and actin-binding activities are mutually suppressed [review] PMID: 15313460
    41. Expression of ExoS in HeLa cells led to a loss of phosphorylation of Ezrin/radixin/moesin proteins that was dependent upon the expression of ADP-ribosyltransferase activity. PMID: 16889625
    42. 2 mutant alleles of RDX in 2 consanguineous families associated with neurosensory hearing loss; sequence analysis of RDX from original DFNB24 family revealed a c.463C>T transition substitution predicted to truncate radixin in the FERM domain PMID: 17226784
    43. increased CD44, ezrin, radixin, and moesin phosphorylation represents a key molecular abnormality that guides T cell adhesion and migration in SLE patients. PMID: 17237445
    44. RDX was differentially expressed in sclerotic hippocampi compared to non-sclerotic ones. PMID: 17515952
    45. Report disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases. PMID: 17725603
    46. Radixin and ezrin play similar roles in the apical membrane localization of ABCC2 (MRP2) and their expression level and subcellular distribution are important factors in the regulation of ABCC2 (MRP2) at the post-transcriptional level. PMID: 17825285
    47. the ezrin, radixin, and moesin proteins function as positive regulators of infection by X4-tropic HIV-1 PMID: 18295815
    48. Unlike ezrin and moesin, radixin (a member of the ezrin-radixin-moesin protein family)is not expressed in Jurkat cells, nor is it involved in apoptotic signaling following Fas receptor triggering in these cells. PMID: 18941185
    49. No aspects of T cell receptor signaling uniquely require transgenic ezrin or moesin; instead, T cell activation appears to depend on net ezrin, radixin, and moesin (ERM)protein expression, while ezrin and moesin function together. PMID: 19124745
    50. In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin PMID: 19129194

    顯示更多

    收起更多

  • 相關疾病:
    Deafness, autosomal recessive, 24 (DFNB24)
  • 亞細胞定位:
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
  • 數據庫鏈接:

    HGNC: 9944

    OMIM: 179410

    KEGG: hsa:5962

    STRING: 9606.ENSP00000342830

    UniGene: Hs.263671



主站蜘蛛池模板: 在线涩涩免费观看国产精品| 欧美老妇交乱视频在线观看| 18禁网站免费无遮挡无码中文| 日本sm/羞辱/调教/捆绑视频| 亚洲 自拍 另类小说综合图区| 亚洲毛片无码不卡av在线播放| 国精品人妻无码一区二区三区蜜柚| 久久综合给合久久狠狠97色| 欧美亚洲精品一区二区 | 成人性做爰aaa片免费看不忠| 韩国理伦片一区二区三区在线播放| 亚洲欧美一区二区三区| 人人澡人人曰人人摸看| 成人午夜精品无码一区二区三区| 成熟女人牲交片免费观看视频| 四虎影成人精品a片| 上司揉捏人妻丰满双乳电影| 最近高清中文在线字幕在线观看1| 亚洲精品无码专区在线播放| 1000部夫妻午夜免费| 播放男人添女人下边视频| 无码专区—va亚洲v专区vr| 东北老女人高潮大喊舒服死了| 亚洲精品无码成人av电影网| 护士人妻hd中文字幕| 麻豆人妻少妇精品无码专区| 色婷婷综合和线在线| 麻豆成人久久精品综合网址| 亚洲中文字幕无码永久在线| 国内自产少妇自拍区免费| 成 人 a v免费视频在线观看 | 免费国产午夜视频在线| 成人永久免费网站在线观看| 亚洲另类无码专区国内精品| 九九热久久只有精品2| 综合五月激情二区视频| 色又黄又爽18禁免费网站现观看 | 久久av无码αv高潮αv喷吹| 欧美亚洲一区二区三区| 国产在线码观看超清无码视频| 免费看成人毛片无码视频|