在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RDH5 Antibody

  • 中文名稱:
    RDH5兔多克隆抗體
  • 貨號:
    CSB-PA856423ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA856423ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA856423ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RDH5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RDH5
  • 別名:
    RDH5 antibody; HSD17B9 antibody; RDH1 antibody; SDR9C5 antibody; Retinol dehydrogenase 5 antibody; EC 1.1.1.209 antibody; EC 1.1.1.315 antibody; EC 1.1.1.53 antibody; 11-cis retinol dehydrogenase antibody; 11-cis RDH antibody; 11-cis RoDH antibody; 9-cis retinol dehydrogenase antibody; 9cRDH antibody; Short chain dehydrogenase/reductase family 9C member 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 11-cis retinol dehydrogenase protein (24-318AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal. Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates.
  • 基因功能參考文獻:
    1. a novel homozygous missense mutation, (c.602 C > T) in exon 4 of the RDH5 gene (MIM: 601617) was identified. This mutation resulted in substitution of phenyl alanine for serine at amino acid 201 (p.Ser201Phe) of the RDH5 gene. Identification of this mutation reveals the allelic heterogeneity of RDH5 in patients with retinitis pigmentosa phenotype. PMID: 29892959
    2. We conclude that the expression of Rlbp1 and Rdh5 critically depends on functional Mitf in the RPE and suggest that MITF has an important role in controlling retinoid processing in the RPE. PMID: 26876013
    3. A novel c.832C>T (p.Arg278Ter) nonsense mutation in RDH5 was identified. Preserved rod function was observed in one young subject in this study. PMID: 25170858
    4. Macular cone density is lower and the regularity of the macular cone mosaic spatial arrangement is disrupted in eyes with fundus albipunctatus. PMID: 24246574
    5. RDH5 sequence analysis revealed a novel five base pair deletion, c.913_917delGTGCT (p.Val305Hisfs*29), in family A, and a novel missense mutation, c.758T>G (p.Met253Arg), in family B with fundus albipunctatus. PMID: 22736946
    6. Four novel RDH5 gene mutations were identified in fundus albipunctatus Israeli patients. Of them, the null mutations c.343C>T (p.R54X) and c. 242delTGCC were the most prevalent. PMID: 22815624
    7. The proband had a compound heterozygotic missense mutation of Cys59Ser (TGC --> AGC) and a nonsense mutation of Trp95ter (TGG --> TGA) in the RDH5 gene. PMID: 22669287
    8. The clinical and electrophysiologic phenotype of patients with RDH5 retinopathy is variable. PMID: 21529959
    9. Mutations in RDH5 associated with fundus albipunctatus seem to prevent normal lipofuscin accumulation. PMID: 20829743
    10. An amino acid important for steroid/retinoid discrimination was identified and its significance was highlighted by the results of molecular modeling studies. PMID: 20382160
    11. Macular dystrophy is caused by the RDH5 mutation as a phenotype variation in fundus albipunctus. PMID: 11812441
    12. Macular dystrophy is caused by the RDH5 gene mutation as a phenotype variation in fundus albipunctatus. PMID: 12788147
    13. Fundus changes due to Fundus albipunctatus associated with mutations in the RDH5 gene. PMID: 12860821
    14. RDH5 gene mutations cause a progressive cone dystrophy or macular dystrophy as well as night blindness. The clinical phenotype including electrophysiological responses varied among patients with the RDH5 gene mutations. PMID: 12906118
    15. A homozygous G490T (Val164Phe) missense RDH5 gene mutation was detected. PMID: 12967826
    16. Homozygous Gly107Arg mutation in the RDH5 gene in two unrelated Japanese families with fundus albipunctatus. PMID: 15007239
    17. Cone dystrophy can be present in patients with fundus albipunctatus, not only elderly men but also young women. PMID: 15302662
    18. Our study indicates that different mutations in the RDH5 gene can cause phenotypic variations of either fundus albipunctatus or familial fleck retina with night blindness. PMID: 16637847
    19. study describes an unusual family which included a mother with fundus albipunctatus and three children with typical retinitis pigmentosa; a novel RDH5 mutation was found PMID: 18363170

    顯示更多

    收起更多

  • 相關疾病:
    Fundus albipunctatus (FALBI)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side.
  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性:
    Widely expressed. In the eye, abundant in the retinal pigment epithelium.
  • 數據庫鏈接:

    HGNC: 9940

    OMIM: 136880

    KEGG: hsa:5959

    STRING: 9606.ENSP00000257895

    UniGene: Hs.600940



主站蜘蛛池模板: 大地资源在线观看官网第三页| 动漫无遮挡羞视频在线观看| 亚洲最大无码中文字幕网站| 免费无码肉片在线观看| 国产乱人无码伦av在线a| 久久精品中文字幕大胸| 亚洲va在线va天堂xx xx| 成人免费无码大片a毛片户外| 极品美女扒开粉嫩小泬| 亚洲欧美国产精品久久久久久久 | 亚洲成av人片在线观看无码| 香蕉久久久久久av成人| 欧洲美熟女乱又伦免费视频| 国产亚洲视频在线观看网址| 国产无人区码一码二码三mba| 美女又黄又免费的视频| 婷婷丁香六月激情综合在线人 | 国产精品一区波多野结衣| 国产高清视频在线观看97| 极品少妇被猛的白浆直喷白浆| 无码人妻精品一区二区在线视频| 亚洲人成网站在线播放小说| 五月丁香六月综合缴情在线| 亚洲人成人网站在线观看| 又黄又爽又无遮挡免费的网站| 精品久久一区二区乱码| 国产产在线精品亚洲aavv| 三个男吃我奶头一边一个视频| 色屁屁www影院免费观看入口| 99久久无码一区人妻a片潘金莲| 久久精品一区二区av999| 国产免费久久精品99久久| 国产精品无码日韩欧| 久久久国产精品无码一区二区| 色综合久久网| 欧美熟妇另类久久久久久多毛 | 亚洲乱亚洲乱妇| 印度妓女野外xxww| 亚洲人成网亚洲欧洲无码| 天天噜日日噜狠狠噜免费| 翘臀后进少妇大白嫩屁股|