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  4. RCC2 Antibody

RCC2 Antibody

  • 中文名稱：
    RCC2兔多克隆抗體
  • 貨號：
    CSB-PA030287
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RCC2
  • 別名：
    KIAA1470 antibody; Protein RCC2 antibody; RCC 2 antibody; RCC1 like protein TD 60 antibody; RCC1-like protein TD-60 antibody; RCC2 antibody; RCC2_HUMAN antibody; Regulator of chromosome condensation 2 antibody; TD60 antibody; Telophase disk protein of 60 kDa antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human RCC2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions. Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro).
  • 基因功能參考文獻：
    1. Study reports that p53 is a transcriptional regulator of RCC2 that acts through its binding to a palindromic motif in the RCC2 promoter. p53 and RCC2 signaling is important for regulation of cell migration and suppression of metastasis. PMID: 28869598
    2. RCC2 regulates apoptosis by blocking Rac1 signaling. RCC2 expression in tumor can be a useful marker for predicting chemotherapeutic response. PMID: 29321004
    3. results suggest that combined exposure to CSE and PM2.5 induces LCPAT1 expression, which up-regulates autophagy, and promotes lung cancer progression via RCC2. PMID: 29913439
    4. RCC2 plays a pivotal role in LUAD metastasis by inducing EMT via activation of MAPK-JNK signaling. PMID: 28606921
    5. Impaired RCC2 affects functional and clinical endpoints of colorectal cancer. High-risk patients with either MSI or MSS tumors can be identified with cost-effective routine RCC2 assays. PMID: 25910952
    6. RCC2 exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase RalA. RCC2 and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis. PMID: 26158537
    7. MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2. PMID: 23442884
    8. TD-60 is an essential regulator of cell cycle progression during interphase. PMID: 23388455
    9. a complex containing cortactin and RCC2/TD60 complex that may play a functional role in cells undergoing mitosis. PMID: 22282019
    10. Studies indicated that DDX21, HNRNPC, and RCC2 were isolated from Ku86 multicomponent complex in response to DNA damage. PMID: 20873769
    11. Data show that TD-60 is a member of the RCC1 family and that it binds preferentially the nucleotide-free form of the small G protein Rac1. PMID: 12919680
    12. Dysregulation of Rac1 and Arf6 function by RCC2 knockdown also abolished persistent migration along fibronectin fibers, indicating a functional role for RCC2 in directional cell movement. PMID: 19738201

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  • 亞細胞定位：
    Nucleus, nucleolus. Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 數據庫鏈接：

    HGNC: 30297

    OMIM: 609587

    KEGG: hsa:55920

    STRING: 9606.ENSP00000364582

    UniGene: Hs.380857



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