在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RBMX Antibody

RBMX Antibody

  • 中文名稱：
    RBMX兔多克隆抗體
  • 貨號：
    CSB-PA296056
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: K562 cells, hela cells, Jurkat cells, Primary antibody: CSB-PA296056(RBMX Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RBMX
  • 別名：
    RBMX antibody; HNRPG antibody; RBMXP1 antibody; RNA-binding motif protein antibody; X chromosome antibody; Glycoprotein p43 antibody; Heterogeneous nuclear ribonucleoprotein G antibody; hnRNP G) [Cleaved into: RNA-binding motif protein antibody; X chromosome antibody; N-terminally processed] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human RBMX
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
  • 基因功能參考文獻：
    1. These results suggest that satellite I RNA plays a role in stabilizing RBMX and Sororin in the ncRNP complex to maintain proper sister chromatid cohesion. PMID: 29383807
    2. HNRNPG binds m6A-methylated RNAs through its C-terminal low-complexity region, which self-assembles into large particles in vitro. The Arg-Gly-Gly repeats within the low-complexity region are required for binding to the RNA motif exposed by m6A methylation. PMID: 28334903
    3. A sequence deletion within RBMX is identified as associated with with Shashi X-linked intellectual disability syndrome. PMID: 25256757
    4. Host RBMX is required for the maintenance of Borna disease virus nuclear viral factories. PMID: 26333388
    5. Results showed that HNRNPG and HTRA2-BETA1 were specific antagonistic regulators of ERa exon7 splicing and increased HNRNPG levels were associated with improved clinical outcome of endometrial cancer through up-regulation of ERaD7 expression. PMID: 25884434
    6. RBMX is a cohesion regulator that maintains the proper cohesion of sister chromatids. PMID: 22832223
    7. Data show that RBMX accumulated at DNA lesions through multiple domains in a poly(ADP-ribose) polymerase 1-dependent manner and promoted HR by facilitating proper BRCA2 expression. PMID: 22344029
    8. studied the genetic and expression states of hnRNP G in normal, premalignant and malignant human oral tissues to further understand the relationship between the hnRNP G alterations and the development of human oral cancer PMID: 21840245
    9. evidence provided that deletions in or around RBMX may be involved in non-obstructive azoospermia(NOA) PMID: 16491274
    10. From these results, it seems that the X-chromosome, through its RBM genes, plays a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer. PMID: 16552754
    11. p53 modulates DNA DSB repair by, in part, inducing hnRNP G PMID: 17387044
    12. This identifies RBMX as an ARTS-1-associated protein that regulates both the constitutive release of TNFR1 exosome-like vesicles and the inducible proteolytic cleavage of TNFR1 ectodomains. PMID: 18445477

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, X-linked, syndromic, 11 (MRXS11)
  • 亞細胞定位：
    Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.
  • 組織特異性：
    Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9910

    OMIM: 300199

    KEGG: hsa:27316

    STRING: 9606.ENSP00000359645

    UniGene: Hs.380118



主站蜘蛛池模板： 日韩加勒比一本无码精品| 色综合久久久久综合体桃花网| 亚洲高清国产拍精品网络战| 日本一区二区三区免费播放视频站| 正在播放国产剧情亂倫| 青青草原综合久久大伊人| 2020久久香蕉国产线看观看| 日产日韩亚洲欧美综合在线| 久久综合精品国产一区二区三区无码| 精品国产午夜福利精品推荐| 日本乱子伦一区二区三区| 蜜臀av午夜一区二区三区| 午夜福利电影网站鲁片大全| 国产传媒精品1区2区3区| 成人午夜精品无码区久久| 久久99精品国产麻豆| 亚洲欧美日本久久综合网站| 久久国产乱子精品免费女| 色悠久久久久综合网国产| 西西人体做爰大胆gogo| 亚洲国产成人爱av在线播放| 国产成人av在线一区二区三区| 日本熟妇人妻xxxx| 国产肉体xxxx裸体137大胆 | 国产亚洲精品福利视频| 国产精品久久久久久2021| 亚洲成av人片在线观看无码不卡| 色一情一乱一伦一区二区三区小说 | 在线中文新版最新版在线| 美女视频黄又黄又免费| 午夜精品乱人伦小说区| 国产亚洲精品久久久久久| 国产自偷在线拍精品热| 四虎成人精品永久网站| 99久久免费精品高清特色大片 | 国产内射合集颜射| 风韵犹存丰满大屁股熟妇视频| 亲近乱子伦免费视频| 精品乱码一区二区三四区视频| 浪荡女天天不停挨cao日常视频| 亚洲一卡2卡3卡4卡5卡乱码观看|