在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RBM7 Antibody, Biotin conjugated

  • 中文名稱:
    RBM7兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA896729LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RBM7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RBM7
  • 別名:
    RBM7 antibody; RNA-binding protein 7 antibody; RNA-binding motif protein 7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human RNA-binding protein 7 protein (5-266AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability.
  • 基因功能參考文獻:
    1. a proline-rich segment of ZCCHC8 as the interaction site for the RNA-recognition motif (RRM) of RBM7 and present the crystal structure of the corresponding complex at 2.0 A resolution. PMID: 27905398
    2. Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation PMID: 27193168
    3. RBM8 and CBP20 RRM-domain crystal structures were used to successfully determine the RBM7 structure by molecular replacement. The structure reveals a ring-shaped pentameric assembly, which is most likely a consequence of crystal packing PMID: 27139832
    4. Phosphorylation of RBM7 by the p38(MAPK)/MK2 axis increases nuclear ncRNA stability by blocking their RBM7-binding and subsequent RNA exosome targeting to allow stress-dependent modulations of the noncoding transcriptome. PMID: 25525152
  • 亞細胞定位:
    Nucleus, nucleoplasm. Nucleus.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 9904

    OMIM: 612413

    KEGG: hsa:10179

    STRING: 9606.ENSP00000439918

    UniGene: Hs.7527



主站蜘蛛池模板: 日韩精品a片一区二区三区妖精| 日韩精品久久久免费观看| 国产午夜永久福利视频在线观看| 国产欧美va天堂在线观看视频| 欧美乱妇高清无乱码| 久久国产精品偷| 欧美人与禽猛交狂配| 尤物av无码国产在线看| 国产专区一线二线三线码| 久久成人伊人欧洲精品| 国产人妻久久精品一区二区三区| 欧洲精品码一区二区三区免费看| 亚洲熟妇av乱码在线观看| 亚洲国产精品久久久久婷蜜芽| 啊轻点内射在线视频| 不卡无码人妻一区二区三区| 女人国产香蕉久久精品| 三上悠亚ssⅰn939无码播放| 强奷人妻日本中文字幕| 四虎影视国产精品久久| 久久无码无码久久综合综合| 日本丰满老妇bbw| 丰满妇女强制高潮18xxxx| 精品少妇无码av无码专区| 免费看国产曰批40分钟| 久久夜色撩人精品国产小说| 无码无套少妇18p在线直播| 中文字幕欧美亚州视频免费| 66亚洲一卡2卡新区成片发布| 精品亚洲一区二区三区在线观看| 中文天堂在线www最新版官网| 亚洲综合无码无在线观看| 日本高清无卡码一区二区| 最新国产在线拍揄自揄视频| 欧美人与动性xxxxx杂| 欧美精品高清在线观看| 熟女少妇在线视频播放| 高清性欧美暴力猛交| 国内野外强奷在线视频| 久久无码精品一区二区三区| 国产精品亚洲欧美大片在线看|