在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RBM5 Antibody

  • 中文名稱:
    RBM5兔多克隆抗體
  • 貨號:
    CSB-PA239401
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells, using RBM5 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using RBM5 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RBM5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RBM5
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human RBM5.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
  • 基因功能參考文獻:
    1. RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD). PMID: 28586478
    2. results provide evidence that RBM10 expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value PMID: 28662214
    3. the mechanism of action of RBM5-AS1 in the WNT pathway via physical interactions with beta-catenin, helping organize transcriptional complexes that sustain colon cancer-initiating cells function. PMID: 27520449
    4. Low RBM5 expression was significantly associated with gliomas. PMID: 28061901
    5. RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer PMID: 28347247
    6. Results show that RBM5 is downregulated in smoke induced tumor; its overexpression inhibits tumor growth through cell cycle arrest and induction of apoptosis suggesting the importance of RBM5 in the pathogenesis of smoking-related cancer. PMID: 26782095
    7. ICG-001 had no apparent effect on the RBM5 levels. PMID: 25738917
    8. RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine. PMID: 25586139
    9. Loss of RBM5 expression is associated with lung adenocarcinoma. PMID: 23721095
    10. expression of RBM5 protein was significantly decreased in cancerous prostatic tissues compared to the normal tissues PMID: 23158838
    11. RBM5 can inhibit the growth of lung cancer cells and induce apoptosis both in vitro and in vivo. PMID: 22866867
    12. Expression of RBM5 mRNA and protein was negatively correlated with expression of EGFR and KRAS mRNA and protein in NSCLC tissues. PMID: 22537942
    13. RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract. PMID: 23017209
    14. RBM5 may serve as a biomarker with the ability to predict a response to cisplatin PMID: 22609235
    15. The results suggest that RBM5 expression is not directly regulated by EGFR in non-smoker related lung adenocarinomas. PMID: 22882865
    16. NMR data analysis of RBM5 RRM2 reveals several features of protein-RNA interfaces. The most striking observation is the presence of two preferred target RNA sequences, the sequences [5'-(CUCUUC)-3'] and [5'-(GAGAAG)-3']. PMID: 22839758
    17. Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. PMID: 22569250
    18. alters expression of genes involved in metastasis PMID: 20338664
    19. p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5. PMID: 20309933
    20. Over-expression of the splice variant LUCA15 shortened the cell cycle and inhibited CD95-mediated apoptosis in CEM-C7 T-cells. PMID: 12581154
    21. LUCA-15/RMB5 sensitises Jurkat cells to apoptosis initiated by anti-Fas antibody, TNF-alpha, or TRAIL. PMID: 15192330
    22. Results provide the first evidence of an apoptotic modulatory role for LUCA-15 in MCF-7 breast carcinoma cell line, which is a non-T cell line. PMID: 15338470
    23. Results suggest that LUCA-15 plays a central role in regulating cell fate consistent with its tumor suppressor activity. PMID: 16546166
    24. H37 was transfected into A549 non-small cell lung cancer cells. A549/H37 cells show significant growth inhibition compared with the vector controls by in vitro and in vivo cell proliferation assays. PMID: 16585163
    25. Results suggest that reversible phosphorylation of RBM5 is a mechanism capable of regulating RBM5 participation in modulating apoptosis, and perhaps tumour suppression. PMID: 16927403
    26. analysis of Hedgehog modulator properties after functional coupling of Smoothened to G15 PMID: 16945339
    27. specific allele types at C1138T and C2185T single nucleotide polymorphisms positions are correlated with different histological subtypes of non-small cell lung cancer PMID: 17606309
    28. In breast tumour tissue, chimeric expression was associated with elevated levels of RBM5 mRNA, and increased tumour size. PMID: 17908320
    29. suggest some of the possible, further- alternative means of the H37/RMB5 gene expression loss in tumor, including defects in transcription and post-transcriptional/translational modifications as well as mechanisms related to haploinsufficiency PMID: 18038152
    30. RBM5 binds to casp-2 pre-mRNA at a U/C-rich sequence immediately upstream of the previously identified In100 splicing repressor element PMID: 18840686
    31. RBM5 inhibits the transition between prespliceosomal complexes assembled around exon 6 to mature spliceosomes assembled on the flanking introns and promotes sequence-specific pairing of the distal splice sites. PMID: 18851835
    32. LUST is a novel, functional, non-coding RNA that plays a role in determining the apoptotic fate of a cell by regulating the expression of RBM5 splice variants. PMID: 19559772

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    RBM5/RBM10 family
  • 組織特異性:
    Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
  • 數據庫鏈接:

    HGNC: 9902

    OMIM: 606884

    KEGG: hsa:10181

    STRING: 9606.ENSP00000343054

    UniGene: Hs.439480



主站蜘蛛池模板: 国产精品va在线观看h| 国产精品99久久精品| 午夜好爽好舒服免费视频| 久久99亚洲精品久久69| 狠狠色狠狠色综合网| 国产最新进精品视频| 欧美又粗又大又硬又长又爽视频| 人人澡人人澡人人看添av| 好吊妞人成视频在线观看27du| 少妇特黄a一区二区三区| 直接观看黄网站免费视频| 无码人妻丝袜在线视频红杏| 曰批全过程免费视频观看软件潮喷 | 国产互换人妻hd| 狼友av永久网站免费观看孕交| 国产精品99爱免费视频| 亚洲免费观看在线视频| 国产极品白嫩精品| 精品无码久久久久国产电影| 青青草原亚洲| 精品人妻伦九区久久aaa片| 国产成人综合久久精品推下载| 亚洲色欲色欲77777小说网站| 国产精品毛多多水多| 天天爽天天爽夜夜爽毛片| 成人免费无遮挡在线播放| 国产乱子伦一区二区三区视频播放| 亚洲伊人成无码综合网| 久久久国产精品消防器材| 成人影院yy111111在线| 囯产精品一区二区三区线| 国产成人无码av在线播放dvd| 污18禁污色黄网站免费| 黑人大战欲求不满人妻| 中文无码伦av中文字幕| 人妻洗澡被强公日日澡| 超薄丝袜足j好爽在线观看| 亚洲精品成a人在线观看| 波多野结衣av一区二区全免费观看 | 国产做a爰片久久毛片a片白丝| 国产性色av一区二区三区|