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  4. RBM4 Antibody, FITC conjugated

RBM4 Antibody, FITC conjugated

  • 中文名稱：
    RBM4兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA880118LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RBM4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RBM4
  • 別名：
    dkfzp547k0918 antibody; hLark antibody; lark antibody; Lark homolog antibody; lark homologue antibody; mgc75138 antibody; RBM4 antibody; rbm4 lark antibody; RBM4_HUMAN antibody; RNA binding motif 4 antibody; RNA binding motif 4a antibody; RNA-binding motif protein 4 antibody; RNA-binding motif protein 4a antibody; RNA-binding protein 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human RNA-binding protein 4 protein (121-205AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
  • 基因功能參考文獻：
    1. The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells. PMID: 28276498
    2. hese findings suggest that RBM4 is a new biomarker in gastric cancer, as the reduced expression of this protein is correlated with poor differentiation, lymph node status and distant metastasis PMID: 27324405
    3. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway. PMID: 29138007
    4. TPM1-AS regulates the alternative splicing of TPM1 through an interaction with RBM4 and involves in TPM1-mediated filopodium formation and migration of cancer cells PMID: 28754317
    5. RBM4 is induced and is involved in the PKM splicing switch and neuronal gene expression during hypoxia-induced neuronal differentiation. PMID: 27821480
    6. alternative splicing patterns were altered by knockdown of RBM4 in several types of neoplasms PMID: 26898347
    7. Loss of RBM4 expression is associated with colorectal cancer. PMID: 26506517
    8. The results indicate that the alanine-rich C-terminal domain, in conjunction with its conjoined RNA-binding domain(s), differentially influences the subnuclear localization and biogenesis of RBM4. PMID: 25414336
    9. Up-regulation of RBM4 is associated with breast cancer. PMID: 25140042
    10. RBM4 is a tumor suppressor with therapeutic potential and clinical values as a prognostic factor. PMID: 25203323
    11. we propose the emerging role of RBM4 in regulating the adipocyte-specific splicing events and transcription cascade, which subsequently facilitate the development and function of brown adipocyte-like cells. PMID: 24389249
    12. role in negative feed-forward loop that disrupts inflammattory cytokine translation following Toll-like receptor 4 response PMID: 23897118
    13. RBM4 homologs exert different effects on 5' splice site utilization and exon selection, and exhibit different subnuclear localization patterns. PMID: 23527094
    14. Data show that RBM4 interacts directly with Ago2 during muscle cell differentiation and may recruit Ago2 to suppress translation of target mRNAs. PMID: 19801630
    15. Data show that the nuclear matrix protein matrin 3, cytoskeletal motor protein HMP, and the circadian clock protein lark were significantly decreased in fetal Down syndrome brain. PMID: 12469345
    16. the regulated alternative splicing of alpha-TM by the antagonistic splicing regulators RBM4 and PTB PMID: 16260624
    17. RBM4 is expressed in the human brain regions affected in tauopathy, including the hippocampus and frontal cortex. RBM4 is involved in tau exon 10 alternative splicing PMID: 16777844
    18. Wilms tumor 1 protein, WT1 interacts with the novel splicing regulator RBM4, the longer isoform of WT1 is able to inhibit the effect of RBM4 on alternative splicing. PMID: 16934801
    19. a previously unrecognized paradigm for the RNA-binding protein RBM4 in its phosphorylation-modulated dual action as a suppressor of cap-dependent and enhancer of IRES-mediated translation in response to stress signals PMID: 17284590
    20. human brain, expression of RBM4a was strongly up-regulated in cerebellum as compared to forebrain. PMID: 18708123
    21. RBM4 is an RNA-binding protein involved in diverse cellular processes that include alternative splicing of pre-mRNA, translation, and RNA silencing. PMID: 18723113
    22. The alternative splicing imbalance of CoAA and RBM4, because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation PMID: 19416963

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  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.
  • 組織特異性：
    Expressed in the cerebellum. Expressed in neurons and glial cells, including layers II neurons in the frontal cortex and CA1 pyramidal neurons in the hippocampus. Expressed in heart, liver, pancreas, skeletal muscle, placenta, primary fibroblasts and peri
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9901

    OMIM: 602571

    KEGG: hsa:5936

    STRING: 9606.ENSP00000425446

    UniGene: Hs.523822



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