在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RBM39 Antibody

  • 中文名稱:
    RBM39兔多克隆抗體
  • 貨號:
    CSB-PA019424GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CAPER alpha antibody; CAPER antibody; CAPERalpha antibody; CC1.3 antibody; Coactivator of activating protein 1 and estrogen receptors antibody; Coactivator of AP1 and ERs antibody; DKFZp781C0423 antibody; FLJ44170 antibody; HCC 1 antibody; Hepatocellular carcinoma protein 1 antibody; RBM 39 antibody; RBM39 antibody; RBM39_HUMAN antibody; RNA binding motif protein 39 antibody; RNA binding region (RNP1 RRM) containing 2 antibody; RNA binding region containing 2 antibody; RNA binding region containing protein 2 antibody; RNA-binding motif protein 39 antibody; RNA-binding protein 39 antibody; RNA-binding region-containing protein 2 antibody; RNPC 2 antibody; RNPC2 antibody; Splicing factor CC1.3 antibody; Splicing factor CC1.4 antibody; Splicing factor HCC 1 antibody; Splicing factor HCC1 antibody; Transcription coactivator CAPER antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RBM39
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity.
  • 基因功能參考文獻:
    1. Decreased expression of CAPERalpha appears to be correlated with appearance of microvessels in hepatocellular carcinoma PMID: 26934653
    2. RBM39 is extensively involved in alternative splicing of RNA and helps regulate transcript levels. RBM39 may modulate alternative splicing similarly to U2AF65 by either directly binding to RNA or recruiting other splicing factors, such as U2AF65. PMID: 27354116
    3. The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1, and RBM39 stabilizes or increases U2 snRNP recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation. PMID: 28193846
    4. This study therefore establishes a structural basis for specific UHM-ULM interactions by splicing factors such as U2AF35, U2AF65, RBM39 and SF3b155, and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells. PMID: 27050129
    5. mammalian c-Abl plays an important role in steroid hormone receptor-mediated transcription by regulating RBM39 PMID: 27018250
    6. Knockdown of CAPER expression markedly reduced human breast cancer cell proliferation in both in vitro and in vivo settings. Mechanistically, knockdown of CAPER abrogated the activity of proliferative and protein synthesis pathways. PMID: 24621503
    7. Our data suggest that overexpression of HCC1/CAPERalpha may increase the proliferation and migration of NSCLC cells, and HCC1/CAPERalpha could be a promising biomarker for lung cancer PMID: 24643682
    8. identify SF3b155 as the relevant ULM-containing partner of full-length CAPERalpha in human cell extracts. PMID: 24795046
    9. Data show that CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. PMID: 22711543
    10. Increased VEGF(165) expression is secondary to the down-regulation of CAPER-alpha by EWS/FLI-1. CAPER-alpha mediates alternative splicing and controls the shift from VEGF(189) to VEGF(165) . PMID: 22009261
    11. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h PMID: 15747776
    12. this study identifies CAPERalpha (RNA binding motif protein 39) as a new transcriptional coregulator for v-Rel and reveals an important role in modulating Rel's oncogenic activity. PMID: 18753212
    13. Analysis of human breast cancer samples revealed that CAPER is overexpressed and undergoes a cytoplasmic-to-nuclear shift during the transition from pre-malignancy to ductal carcinoma in situ PMID: 19342371
    14. This paper describes the mouse gene. PMID: 11704680

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus speckle.
  • 蛋白家族:
    Splicing factor SR family
  • 組織特異性:
    Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain. Expressed at intermediate level in kidney, liver and heart.
  • 數據庫鏈接:

    HGNC: 15923

    OMIM: 604739

    KEGG: hsa:9584

    STRING: 9606.ENSP00000253363

    UniGene: Hs.282901



主站蜘蛛池模板: 农民人伦一区二区三区| 无码啪啪熟妇人妻区| 亚洲欧美日韩一区在线观看 | 69久久精品无码一区二区无码| 欧美国产日本高清不卡| 久久精品人妻无码一区二区三区 | 亚洲另类欧美小说图片区 | 精品国产免费第一区二区三区| 999国内精品永久免费观看| 粗大的内捧猛烈进出在线视频| 永久黄网站色视频免费| 性欧美疯狂xxxxbbbb| 亚洲中文无码永久免| 欧美又黄又大又爽a片三年片| 国产精品午夜无码av天美传媒| 精品国产一区二区三区四区五区| 亚洲偷自拍国综合色帝国| 老司机性色福利精品视频| 英语老师丝袜娇喘好爽视频| 国产精品亚韩精品无码a在线| 欧美精品乱码99久久蜜桃| 国产日本精品视频在线观看| 日本成a人片在线播放| 亚洲丰满熟女一区二区v| 国模裸体无码xxxx视频| 国产欧美综合在线观看第十页 | 日韩欧美tⅴ一中文字暮| 欧美肥老太牲交大战| 天堂www中文在线资源| 特级无码毛片免费视频尤物| 久久国内精品自在自线观看 | 欧美牲交a欧美牲交| 亚洲熟女综合一区二区三区| 日本在线a一区视频| 亚洲欧美不卡视频在线播放| 少妇人妻系列无码专区视频| 精品国内自产拍在线播放观看 | 日本黄页网站免费观看| 国产成人精品三级在线影院| 都市激综合小说区另类区| 日韩精品久久无码人妻中文字幕|