在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RBL1 Antibody

  • 中文名稱:
    RBL1兔多克隆抗體
  • 貨號:
    CSB-PA019398GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    107 kDa retinoblastoma-associated protein antibody; Cellular protein 107 antibody; Cellular protein p107 antibody; CP107 antibody; MGC40006 antibody; p107 antibody; PRB1 antibody; RBL1 antibody; RBL1_HUMAN antibody; Retinoblastoma like protein 1 antibody; retinoblastoma-like 1 (p107) antibody; Retinoblastoma-like protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RBL1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
  • 基因功能參考文獻:
    1. Study found that the methylation of global DNA decreased gradually after irradiation, and the methylation of the promoter of RBL1 gene may play an important role in the induction of radioresistance for three dimensional cultured carcinoma cells. PMID: 27779109
    2. These findings in human skeletal muscle suggest that attenuated transcriptional repression through p107 may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise. PMID: 28270591
    3. The authors found that phosphorylation of residues S650 and S975 in p107 weakens the E2F4 transactivation domain binding. PMID: 27567532
    4. UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins PMID: 28289097
    5. Sequence analysis of the RB1 gene detected a novel mutation in bilateral retinoblastoma. PMID: 22729126
    6. MAGE-A11 is a proto-oncogene whose increased expression in prostate cancer reverses retinoblastoma-related protein p107 from a transcriptional repressor to a transcriptional activator of the androgen receptor and E2F1. PMID: 23853093
    7. Single nucleotide polymorphism in the ultraconserved elements of RBL1 gene is associated with recurrence in colorectal adenocarcinoma. PMID: 22673945
    8. Concomitant germline large cytogenetic 13q deletion and somatic mutations in the RB1 gene in unilateral retinoblastoma. PMID: 22303805
    9. may have a role in the mechanisms of proliferation and differentiation during human placental development PMID: 11642725
    10. regulation of expression of p130, p107 and E2F-4 in human cells PMID: 12006580
    11. suggests that the p107 N-terminus provides an interaction domain for transcription factors involved in cell cycle control PMID: 12439743
    12. report shows hypophosphorylation of the retinoblastoma family proteins induced by H2O2 was because of the activity of protein phosphatase 2A PMID: 12621062
    13. p107 plays a constitutive role in the progression of papillary carcinoma of the thyroid and that decreased p107 expression may contribute to the transformation from follicular adenoma to follicular carcinoma and anaplastic transformation. PMID: 14666683
    14. Induction of p130 and p107 play an important role in the inhibition of growth of C33A cells by MIS. PMID: 14671316
    15. the PP2A catalytic subunit (PP2A/C) specifically interacts with both p130 and p107 in quiescent cells as well as cells progressing throughout the cell cycle PMID: 15467457
    16. Data suggest that p107, in addition to its interaction with E2F, inhibits cell proliferation through the control of Skp2 expression and the resulting stabilization of p27. PMID: 15631990
    17. p107 is a trancriptional regulator of the cell cycle genes. PMID: 16135806
    18. These results demonstrate a mechanistic role for p130 and compensatory roles for p107 and RB in the long-term senescence-like growth arrest response of breast cancer cells to DNA damage. PMID: 16537896
    19. The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750
    20. Differentiating human adipose-derived human stem cells (hASC), do not undergo clonal expansion and p130 expression gradually diminishes across differentiation. However, p107 expression is transiently increased during hASC differentiation. PMID: 18086563
    21. P107 is needed for initiation of accelerated cellular senescence in the absence of Rb and introduces the concept that p130 may be required to prevent the onset of terminal growth arrest in unstimulated prostate cancer cells lacking a functional Rb allele. PMID: 18418057
    22. These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex. PMID: 18799622

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Retinoblastoma protein (RB) family
  • 數據庫鏈接:

    HGNC: 9893

    OMIM: 116957

    KEGG: hsa:5933

    STRING: 9606.ENSP00000362768

    UniGene: Hs.207745



主站蜘蛛池模板: 亚洲人成色77777在线观看大战p| 日韩人妻无码一区二区三区综合 | 亚洲国产日韩a在线播放| 久久天天躁狠狠躁夜夜96流白浆| 99无码熟妇丰满人妻啪啪| 久久人人爽av亚洲精品天堂| 国内揄拍国产精品人妻门事件| 国产制服丝袜亚洲高清| а√最新版在线天堂| 一区二区在线 | 欧洲| 99蜜桃臀久久久欧美精品网站| 成人h动漫无码网站久久| 国产午夜福利不卡在线观看| av电影在线观看| 亚洲国产精品久久久久秋霞影院| 亚欧免费无码aⅴ在线观看蜜桃| 曰本一道本久久88不卡| 久九九久视频精品免费| av永久天堂一区二区三区| 国产又粗又猛又大爽老大爷| 成在线人av无码高潮喷水| 亚洲中文无码线在线观看| 影音先锋无码aⅴ男人资源站| 99久久久无码国产精品试看| 亚洲欧洲免费三级网站| 亚洲精品久久久久avwww潮水| 亚洲精品久久久中文字幕痴女| 在线欧美日韩制服国产| 日韩精品专区在线影院重磅| 双乳奶水饱满少妇呻吟| 18禁白丝喷水视频www视频| 亚洲中文字幕无码久久2020 | 国产卡1卡2卡3麻豆精品免费| 国产精品久久午夜夜伦鲁鲁| 欧美人与动牲交a欧美| 国产欧美一区二区精品仙草咪| 亚洲熟妇自偷自拍另类| 97视频在线观看播放| 99久久无色码中文字幕人妻 | 亚洲人成电影网站色www| 狠狠躁夜夜躁人人爽蜜桃 |