在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RBBP7 Antibody, HRP conjugated

RBBP7 Antibody, HRP conjugated

  • 中文名稱：
    RBBP7兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA621959LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RBBP7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RBBP7
  • 別名：
    G1/S transition control protein binding protein RbAp46 antibody; Histone acetyltransferase type B subunit 2 antibody; Histone binding protein RBBP7 antibody; Histone-binding protein RBBP7 antibody; MGC138867 antibody; MGC138868 antibody; Nucleosome remodeling factor subunit RBAP46 antibody; Nucleosome-remodeling factor subunit RBAP46 antibody; RBAP46 antibody; RBBP 7 antibody; RBBP-7 antibody; RBBP7 antibody; RBBP7_HUMAN antibody; Retinoblastoma binding protein 7 antibody; Retinoblastoma binding protein p46 antibody; Retinoblastoma-binding protein 7 antibody; Retinoblastoma-binding protein p46 antibody; Retinoblastoma-binding protein RbAp46 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Histone-binding protein RBBP7 protein (1-425AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
  • 基因功能參考文獻：
    1. show that BCL11A(2-16) pulls down RBBP4, RBBP7, and other components of PRC2, NuRD, and SIN3A from the cell lysate of the TNBC cell line SUM149 PMID: 29263092
    2. RBBP7 controls the stability of HUWE1.RBBP7 is the E3 ligase responsible for the proteasomal degradation of HUWE1. PMID: 29738775
    3. Taken together with previous findings this suggests, that MTA-RBBP is a stable complex, with a central role in the initial assembly of the human NuRD complex. PMID: 28179136
    4. NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor. PMID: 26257059
    5. Results show a novel interaction of the Lsm4 RGG domain with HAT1 and RBBP7, leading to the possibility of a posttranslational modifications network involved in mRNP regulation. PMID: 27247266
    6. the CRL4 complex containing RBBP7 (CRL4(RBBP7)) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle. PMID: 25795299
    7. Ras induced RbAp46 expression increases invasion of bladder cancer cells. PMID: 25885317
    8. Both of RbAp46 mRNA and protein levels were upregulated significantly in NSCLC cancer tissues. Serum levels of RbAp46 were markedly higher in NSCLC patients than in healthy controls. PMID: 19655816
    9. RbAp46 expression suppresses the transformed phenotypes of breast cancer cells, and dysregulation of RbAp46 expression may contribute to breast cancer tumorigenesis. PMID: 14666671
    10. RbAp46 inhibits cell growth and suppresses the transformed phenotypes of tumor cell lines. PMID: 14981905
    11. RT-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues. PMID: 17314274
    12. RbAp46 folds into a seven-bladed beta propeller structure and binds histone H4 in a groove formed between an N-terminal alpha helix and an extended loop inserted into blade six. PMID: 18571423

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat RBAP46/RBAP48/MSI1 family
  • 數據庫鏈接：

    HGNC: 9890

    OMIM: 300825

    KEGG: hsa:5931

    STRING: 9606.ENSP00000369424

    UniGene: Hs.495755



主站蜘蛛池模板： yy111111少妇无码理论片 | 一本大道东京热无码| 欧美颜射内射中出口爆在线| 无码人妻精品一区二区三区久久久| 中文字幕久久久久人妻中出| 日本久久综合久久鬼色| 国产成人精品亚洲777人妖| 永久免费的av在线电影网无码| 亚洲欧洲日产国码无码av一| 香港台湾经典三级a视频| 人人做人人爽久久久精品| 国产日产欧产美韩系列影片| 国产亚洲精品久久久久四川人| 欧美金妇欧美乱妇xxxx| 五月丁香啪啪激情综合色九色| 国产成人精品午夜福利不卡 | 精品国产自在现线电影| 国产成人无码一区二区三区在线| 日本免费人成视频播放| av无码动漫一区二区三区精品| 亚洲sm另类一区二区三区| 日本人与黑人做爰视频网站| 国产精品美女被遭强扒开双腿| 亚洲aⅴ综合色区无码一区| 做性久久久久久| 五月丁香综合激情六月久久| 天堂а√中文在线官网| 免费观看性行为视频的网站| 欧美最猛性xxxxx大叫| 护士被强女千到高潮视频| 野外做受又硬又粗又大视频| 免费看成人aa片无码视频| 中本亚洲欧美国产日韩| 精品国产av一二三四区| 天堂网www在线资源中文| a毛片免费全部播放自慰| 精品人妻va出轨中文字幕| 久久人搡人人玩人妻精品首页| 亚洲中文在线播放一区| 在线看片免费人成视频国产片| 国产精品久久久久一区二区三区|