在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RBBP5 Antibody

RBBP5 Antibody

  • 中文名稱：
    RBBP5兔多克隆抗體
  • 貨號：
    CSB-PA040179
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of CoLo cells using RBQ-3 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RBBP5
  • 別名：
    RBBP 5 antibody; RBBP-5 antibody; RBBP5 antibody; RBBP5_HUMAN antibody; RBQ 3 antibody; RBQ3 antibody; Retinoblastoma binding protein 5 antibody; Retinoblastoma binding protein RBQ3 antibody; Retinoblastoma binding protein5 antibody; Retinoblastoma-binding protein 5 antibody; Retinoblastoma-binding protein RBQ-3 antibody; SWD1 antibody; SWD1; Set1c WD40 repeat protein; homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RBQ-3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
  • 基因功能參考文獻：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. this study shows that during epithelial-mesenchymal transition in the prostate cancer cell line RbBP5 binding is increased in the vicinity of Snail transcription start site PMID: 27566588
    3. different cancer mutations in MLL1 lead to a loss or increase in activity, illustrating the complex and tumor-specific role of MLL1 in carcinogenesis. PMID: 28182322
    4. role of RBQ3 in the development of multiple myeloma PMID: 27189701
    5. This study demonstrated that RBQ3 might play an important role in glioma, and RBQ3 inhibitors might be novel anti-tumor agents. PMID: 26671109
    6. The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L, RbBP5, WDR5, HCF-1, DBC-1, and EMSY. PMID: 19131338
    7. Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L heterodimer. PMID: 24680668
    8. Data indicate that MLL1 methylates Ash2L in the absence of histone H3, but only when assembled within a complex with WDR5 and RbBP5. PMID: 24235145
    9. structural and biochemical analyses reveal a basic surface on Ash2L as the RbBP5-binding interface, and this interface is crucial for both RbBP5 binding and MLL1 methyltransferase activity regulation PMID: 22231628
    10. MLL1 SET domain make direct contacts with the substrates and contribute to the formation of a joint catalytic center. PMID: 21124902
    11. Results show that Depletion of CHD8 enhances HOXA2 expression and a loss of the WDR5/Ash2L/RbBP5 subcomplex. PMID: 20085832
    12. analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1 PMID: 16604156

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 9888

    OMIM: 600697

    KEGG: hsa:5929

    STRING: 9606.ENSP00000264515

    UniGene: Hs.519230



主站蜘蛛池模板： 区二区欧美性插b在线视频网站| 中文字幕无码免费不卡视频| 成在人线av无码免费高潮水老板| 又黄又爽又色的视频| 强制高潮18xxxx按摩| 久久成人伊人欧洲精品| 亚洲熟女乱色一区二区三区| 少妇做爰免费视频网站| 在线观看麻豆国产成人av在线播放 | 天天躁日日躁狠狠躁超碰97| 伊人大香人妻在线播放| 午夜人妻理论片天堂影院| 亚洲精品国产一区黑色丝袜| 国产av无码专区亚洲a∨毛片| 欧美巨波霸乳影院| 亚洲国产美国国产综合一区| 强奷妇系列中文字幕| 久久av无码精品人妻糸列| 久久这里只有精品18| 成人无码www在线看免费| 无码av不卡免费播放| 鲁鲁网亚洲站内射污| 亚洲中文字幕无码中文字在线| 亚洲国产一区二区三区| 人妻精品制服丝袜久久久| 国产精品久久国产精麻豆99网站 | 国产国拍亚洲精品av| 成人免费毛片内射美女-百度| 免费看欧美成人a片无码| 免费看无码毛视频成片| 国产免费又色又爽又黄软件| 野外做受又硬又粗又大视幕| 人妻少妇中文字幕久久| 日韩人妻中文无码一区二区七区| 亚洲中文色欧另类欧美| 免费观看男女性高视频| 嫩草av久久伊人妇女超级a| 成人aa免费视频在线播放| 久久九九精品国产av片国产| 国产一区二区三区内射高清| 红桃av一区二区三区在线无码av |