在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RASSF6 Antibody

RASSF6 Antibody

  • 中文名稱：
    RASSF6兔多克隆抗體
  • 貨號：
    CSB-PA754570ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA754570ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA754570ESR2HU at dilution of 1:100
    • IHC image of CSB-PA754570ESR2HU diluted at 1:263 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RASSF6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    RASSF6 antibody; Ras association domain-containing protein 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras association domain-containing protein 6 protein (1-303AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.
  • 基因功能參考文獻：
    1. RASSF6 is down-regulated and exhibits tumor suppressor activities in hepatocellular carcinoma. PMID: 27983932
    2. Study reports the interaction of BCL-XL with RASSF6. BCL-XL inhibits the interaction between RASSF6 and MDM2 and suppresses p53 expression. Consequently, BCL-XL antagonizes RASSF6-mediated apoptosis. Thus, the inhibition of RASSF6-mediated apoptosis also underlies the prosurvival role of BCL-XL. PMID: 29193479
    3. Data suggest that Ras-association domain family protein 6 (RASSF6) may serve as a candidate against tumor growth for sporadic colorectal cancer (sCRC). PMID: 27009808
    4. RASSF6 and RASSF10 were frequently hypermethylated in the samples at the time of diagnosis of adult acute lymphoblastic leukemia patients PMID: 28869817
    5. Overexpression or silencing of RASSF6 could partially reverse the effects of the overexpression or repression of miR-181a-5p on GC progress caused by activation of the MAKP pathway in vitro and in vivo. PMID: 28043911
    6. Results suggest that down-regulation of RASSF2, and RASSF6 is a tumor-specific phenomenon and their inactivation through CpG island methylation may play important roles in gastric cardia carcinogenesis. PMID: 26456015
    7. Mechanistic investigation shows that RASSF6 triggers p21(Cip1/Waf1) accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents, and both of these mechanisms appear to be mediated by activated JNK signaling. PMID: 24626183
    8. RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with pancreatic ductal adenocarcinoma. PMID: 26074700
    9. RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.RASSF6 exhibits the highest frequency of inactivation in melanoma and in melanoma brain metastases. PMID: 25482183
    10. downregulation of RASSF6 in highly metastatic nasopharyngeal carcinoma cells contributed to their treatment resistance PMID: 25028967
    11. RASSF6-induced apoptosis partially depends on p53. RASSF6 binds MDM2 and facilitates its ubiquitination. RASSF6 depletion blocks the increase of p53 in response to UV exposure and up-regulation of p53 target genes. PMID: 24003224
    12. Decreased expression of RASSF6 is associated with gastric cancer. PMID: 21442347
    13. These findings indicate that RASSF6 is implicated in apoptosis in HeLa cells and that it triggers both caspase-dependent and caspase-independent pathways. PMID: 17367779
    14. Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members. PMID: 17404571
    15. Sequencing revealed RASSF6 and RASSF10 were the only RASSF members with a high frequency of leukaemia-specific methylation. PMID: 19570220
    16. activation of MST2 causes apoptosis through the Hippo pathway, as well as through a RASSF6-mediated pathway PMID: 19797269

    顯示更多

    收起更多

  • 組織特異性：
    Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the n
  • 數據庫鏈接：

    HGNC: 20796

    OMIM: 612620

    KEGG: hsa:166824

    STRING: 9606.ENSP00000340578

    UniGene: Hs.529677



主站蜘蛛池模板： 日韩人妻无码精品系列专区| 97精品国产97久久久久久免费| 亚洲精品国产一区二区的区别| 欧美亚洲另类自拍丝袜| 亚洲人成网站在小说| 玩弄japan白嫩少妇hd小说| 国产99久一区二区三区a片| 2020最新国产高清毛片| 国产欧美日韩亚洲18禁在线| 狠狠色丁香久久综合婷婷| 亚洲成a人片在线观看www| 色一情一区二| 2021少妇久久久久久久久久| 香蕉视频在线精品视频| 亚洲熟女乱色综合亚洲图片| 丁香五月亚洲综合深深爱| 中文字幕乱码免费专区| 国产免码va在线观看免费| 国产精品一品二区三区的使用体验 | 国产亚洲精品久久yy50| 国产精品99久久精品爆乳 | 亚洲一区二区三区| 巨胸不知火舞露双奶头无遮挡| 国产婷婷成人久久av免费高清| 日本大胆欧美人术艺术| 丁香五月综合久久激情| 舌头伸进去搅动好爽视频| 韩国乱码伦视频免费| 国内精品视频自在一区| 国产男女嘿咻视频在线观看| 藏春阁福利视频| 久久人人爽人人爽人人爽| 国产精品一区二区在线蜜芽tv| 性无码专区一色吊丝中文字幕 | 又色又爽又黄的视频日本| 乱色熟女综合一区二区三区 | 亚洲精品欧美精品日韩精品| 国产+成+人+亚洲欧洲自线 | 天天鲁一鲁摸一摸爽一爽| 五月婷婷俺也去开心| 中文av岛国无码免费播放|