在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RASGRP1 Antibody, Biotin conjugated

  • 中文名稱:
    RASGRP1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA019362LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RASGRP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    RASGRP1 antibody; RASGRPRAS guanyl-releasing protein 1 antibody; Calcium and DAG-regulated guanine nucleotide exchange factor II antibody; CalDAG-GEFII antibody; Ras guanyl-releasing protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human RAS guanyl-releasing protein 1 protein (594-716AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
  • 基因功能參考文獻:
    1. Histidine 212 is located at the fulcrum of these conformational changes, and structural features in its vicinity are consistent with its function as a pH-dependent switch. PMID: 28952923
    2. The rs7170151 in RASGRP1 showed novel associations in IgA nephropathy. PMID: 27804980
    3. The marked differences between RasGRP3 and RasGRP1 in membrane interaction necessarily will contribute to their different behavior in cells. PMID: 28912101
    4. Cytokines IL-2/7/9 stimulation activates PI3K/Akt pathways downstream of Ras in RasGRP1 T-cell acute lymphoblastic leukemia (T-ALL). PMID: 26549032
    5. results demonstrate the critical role of CalDAG-GEFI in rapid alphaIIbbeta3 activation of human platelets. PMID: 27663674
    6. Low-level expression of CD-GEFI impairs platelet activation, leading to protection from thrombosis, but not to marked bleeding in mice. PMID: 27417588
    7. This study shows that deficiency in RASGRP1 results in a previously unknown primary immunodeficiency disease, and that RASGRP1 plays role in immune cell signaling and function in T cells, B cells and NK cells. It also identifies a previously unknown role for RASGRP1 in the dynamic regulation of the cytoskeleton, and identify lenalidomide as a potpotential treatment option for this immunodeficiency. PMID: 27776107
    8. This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population. PMID: 26076219
    9. present a crystal structure of a fragment of RasGRP1 in which the Ras-binding site is blocked by an interdomain linker and the membrane-interaction surface of RasGRP1 is hidden within a dimerization interface PMID: 23908768
    10. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. PMID: 22961080
    11. This is the first study aimed at evaluating CalDAG-GEFI gene sequences in people with mucocutaneous bleeding of unknown cause. PMID: 21815871
    12. PAQR10 and PAQR11 are able to interact with RasGRP1, a guanine nucleotide exchange protein of Ras, and increase Golgi localization of RasGRP1. The C1 domain of RasGRP1 is both necessary and sufficient for the interaction of RasGRP1 with PAQR10/PAQR11. PMID: 21968647
    13. cooperation between aberrant expression of RasGRP1, a strong activator of Ras, and secondary gain-of-function mutations of NOTCH1 have an important role in T-cell leukemogenesis PMID: 22116551
    14. remission in systemic lupus erythematosus activity associated with decreased RasGRP-1 expression in lymphocytes PMID: 21976405
    15. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRalpha gene expression. PMID: 21966541
    16. SDF-1 treatment of T cells induced the formation of a novel molecular signaling complex containing RasGRP1, Galphai2, and ZAP-70. PMID: 21856938
    17. Data show that the RASGRP1/APTX gene expression ratio was higher in the responder while the AKAP13 expression was higher in the non-responders. PMID: 19960345
    18. in response to Src-dependent activation of phospholipase Cgamma1, the Ras guanine nucleotide exchange factor RasGRP1 translocated to the Golgi where it activated Ras PMID: 12845332
    19. RasGRP binds to three DAG molecular species, but only DAG-AA and DAG-DHA participate in the modulation of RasGRP-mediated activation of MAP kinases in Jurkat T cells PMID: 14583629
    20. RasGRP1 transgene conferred pre-TCR-independent survival and proliferation of immature thymocytes, suggesting that deregulated expression of RasGRP1 promotes lymphomagenesis by expanding the pool of thymocytes which are susceptible to transformation. PMID: 15829980
    21. RasGRP1-/- mast cells had markedly reduced degranulation and cytokine production. PMID: 17190838
    22. The unusual RasGRP-SOS interplay results in sensitive and robust Ras activation that cannot be achieved with either activator alone. PMID: 17283063
    23. CalDAG-GEFI as a critical regulator of inside-out integrin activation in human T lymphocytes, neutrophils, and platelets. PMID: 17576779
    24. These results suggest that SKAP55 modulates signal transduction from the T cell antigen receptor to Ras by binding to RasGRP1. PMID: 17658605
    25. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 mediated human T-cell adhesion. PMID: 17702895
    26. identify 13 new splice variants of the human RasGRP1 gene PMID: 17878389
    27. Stimulation of human mast cells by activated T cells leads to N-Ras activation through Ras guanine nucleotide releasing protein 1. PMID: 18760455
    28. Studied RASGRP1, found 1 locus, mapping to a linkage disequilibrium (LD) block at chr15q14, reached statistical significance by combining results from two markers. PMID: 19465406

    顯示更多

    收起更多

  • 相關疾病:
    Systemic lupus erythematosus (SLE)
  • 亞細胞定位:
    Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族:
    RASGRP family
  • 組織特異性:
    Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level).
  • 數據庫鏈接:

    HGNC: 9878

    OMIM: 152700

    KEGG: hsa:10125

    STRING: 9606.ENSP00000310244

    UniGene: Hs.591127



主站蜘蛛池模板: 天天躁夜夜躁av天天爽| 人妻少妇精品视频无码专区| 成人一在线视频日韩国产| 久久久国产精品无码一区二区 | 蜜桃av无码免费看永久| 欧美性生交xxxxx无码久久久| 亚洲国产欧美中文丝袜日韩 | 国产98在线 | 免费| 一本久道综合色婷婷五月| 久久国产精品波多野结衣av| 77777亚洲午夜久久多人| 无码av片av片av无码| 西西人体大胆无码视频| 久久经精品久久精品免费观看 | 3d动漫精品啪啪一区二区免费| 日本最新免费二区| 国产卡二卡三卡四卡免费网址 | 无码啪啪熟妇人妻区| 天天摸天天做天天爽水多| 亚洲国产成人乱码| 久久亚洲精品国产亚洲老地址| 人妻人人澡人人添人人爽人人玩| 尤物蜜芽国产成人精品区| 国产精品久久久久久久久久| 成熟老妇女视频| 国产午夜精品久久精品电影 | 国产成人无码a区视频在线观看 | 亚洲精品~无码抽插| 亚洲熟妇av午夜无码不卡| 三级全黄的视频在线观看| 成人区人妻精品一区二区三区| 曰本女人与公拘交酡免费视频| 亚洲 欧美 天堂 综合| 又粗又黄又爽视频免费看| 337p日本欧洲亚洲大胆张筱雨| 日本高清无卡码一区二区久久| 99精品热在线在线观看视频| 久久精品免费一区二区三区| 久久精品国产丝袜人妻| 狼人大香伊蕉国产www亚洲| 色欲来吧来吧天天综合网|