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Your Good Partner in Biology Research

RASEF Antibody

  • 中文名稱:
    RASEF兔多克隆抗體
  • 貨號:
    CSB-PA019356GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    RASEF
  • 別名:
    RASEF antibody; RAB45 antibody; Ras and EF-hand domain-containing protein antibody; Ras-related protein Rab-45 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Human RASEF
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules.
  • 基因功能參考文獻:
    1. Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. PMID: 24703243
    2. overexpression of RAB45 increased the phosphorylation levels of p38, resulting in the induction of apoptosis and inhibition of proliferation of CML progenitor cells PMID: 21890458
    3. Homozygosity, in combination with methylation, appears to be the mechanism targeting RASEF in uveal melanoma, and allelic imbalance at this locus supports a TSG role for RASEF. PMID: 18385040
  • 亞細胞定位:
    Cytoplasm, perinuclear region.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 組織特異性:
    Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
  • 數據庫鏈接:

    HGNC: 26464

    OMIM: 611344

    KEGG: hsa:158158

    STRING: 9606.ENSP00000365630

    UniGene: Hs.129136



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