在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RASAL1 Antibody

  • 中文名稱:
    RASAL1兔多克隆抗體
  • 貨號:
    CSB-PA912569
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA912569(RASAL1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA912569(RASAL1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GAP1 like protein antibody; MRASAL antibody; RAS GTPase activating protein like antibody; RAS protein activator like 1 (GAP1 like) antibody; RAS protein activator like 1 antibody; RASAL antibody; Rasal1 antibody; rasGAP activating like protein 1 antibody; RasGAP-activating-like protein 1 antibody; RASGAP1 LIKE antibody; RASL1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human RASAL1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:20-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.
  • 基因功能參考文獻:
    1. Domain topology of human Rasal PMID: 28885980
    2. HIF1alpha and transforming growth factor (TGF)/SMAD signalling pathways synergistically regulate hypoxia-induced endothelial-to-mesenchymal transition through both DNMT3a-mediated hypermethylation of RASAL1 promoter and direct SNAIL induction. PMID: 27012941
    3. RASAL1 role in in sorafenib-resistance of liver cancer cells PMID: 27878301
    4. our study showed significantly longer overall survival times for oesophagogastric adenocarcinoma patients without RASAL1 expression PMID: 28011578
    5. DNA methylation, TGFbeta1 and RASAL1 appear to have an interacting relationship. PMID: 27124111
    6. Report a new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification. PMID: 26997440
    7. These findings suggest that Ebp1 suppressed thyroid cancer cell lines by upregulating RASRAL expression. PMID: 26008146
    8. large chromosome 12 rearrangement, spanning MDM2 and RASAL1, is the first recurrent molecular abnormality to be reported in juvenile ossifying fibroma PMID: 24925056
    9. Loss of RASAL1 expression is associated with gastric carcinogenesis. PMID: 25735335
    10. Transcriptional suppression of RASAL1 through aberrant promoter methylation contributes to endothelial-mesenchymal transition and ultimately to progression of cardiac fibrosis. PMID: 25616414
    11. Promoter hypermethylation of the RASAL1 gene was detected in MKN-28, SGC-790l and BGC-823 cancer cells. PMID: 24377515
    12. It is a tumor suppressor gene which influences the proliferation and invasion of gastric cancer by regulating RAS/ERK signaling pathway. PMID: 24531877
    13. Germline RASAL1 alterations are uncommon in patients with Cowden syndrome but may not be infrequent in patients with apparently sporadic follicular-variant papillary thyroid cancer. PMID: 24712574
    14. We identified RASAL1 as a major tumor suppressor gene that is frequently inactivated by hypermethylation and mutations, providing a new alternative genetic background for thyroid cancer, particularly FTC and ATC. PMID: 24136889
    15. Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium PMID: 23665422
    16. decreased RASAL1 expression is a characteristic of gastric cancer and regulated by epigenetic mechanisms PMID: 22825043
    17. Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. PMID: 23251034
    18. Reduced expression of RAS protein activator like-1 is associated with gastric cancer. PMID: 20473946
    19. Galpha and Gbeta gamma require distinct Src-dependent pathways for its activation PMID: 12221082
    20. RASAL preservs of Ca2+ frequency information PMID: 16009725
    21. RASAL constitutes a tumor suppressor gene and therefore further emphasized the importance of Ca(2+) in the regulation of Ras signaling and has established that deregulation of this pathway is an important step in Ras-mediated tumorigenesis PMID: 17640920
    22. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. PMID: 18992247

    顯示更多

    收起更多

  • 組織特異性:
    Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea. Expressed in melanocytes.
  • 數據庫鏈接:

    HGNC: 9873

    OMIM: 604118

    KEGG: hsa:8437

    STRING: 9606.ENSP00000450244

    UniGene: Hs.528693



主站蜘蛛池模板: 亚洲国产福利一区二区三区| 国产日产欧产精品精品ai| 东京热无码一区二区三区av | 中国大陆精品视频xxxx| 18禁裸体动漫美女无遮挡网站| 欧美日韩精品一区二区视频| www激情内射在线看| 伊人色综合一区二区三区影院视频| 精品国内在视频线2019| 2020久久香蕉国产线看观看| 亚洲gv永久无码天堂网| 国产成人精品午夜福利不卡| 久久无码人妻影院| 琪琪电影午夜理论片八戒八戒| 国内一区二区三区香蕉aⅴ| 又色又爽又黄的视频日本| 国产精品美女久久久网av| 无码中文av有码中文a| 人妻.中文字幕无码| 午夜免费男女aaaa片| 日本熟妇人妻xxxxx| 99久热re在线精品视频| 夜夜爽妓女8888888视频| 亚洲最大天堂无码精品区| 中年人妻丰满av无码久久不卡| 精品性影院一区二区三区内射 | 欧美精品高清在线观看| 欧美黑人与白人精品a片| 偷自拍亚洲视频在线观看99| 97人妻天天摸天天爽天天| 国产激情久久久久影院老熟女免费| 亚拍精品一区二区三区探花 | 亚洲 一区二区 在线| 成人女人看片免费视频放人| 国模欢欢炮交啪啪150| 日本真人边吃奶边做爽动态图| 一本一久本久a久久精品综合| 日韩国产成人精品视频| 精品国产福利一区二区| 日韩国产综合精选| 无码国产精品一区二区免费式芒果|