在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAPGEF4 Antibody

  • 中文名稱:
    RAPGEF4兔多克隆抗體
  • 貨號:
    CSB-PA820189ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA820189ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA820189ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RAPGEF4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CAMP GEFII antibody; cAMP regulated guanine nucleotide exchange factor II antibody; cAMP-GEFII antibody; cAMP-regulated guanine nucleotide exchange factor II antibody; CAMPGEFII antibody; CGEF 2 antibody; CGEF2 antibody; Epac 2 antibody; EPAC2 antibody; Exchange factor directly activated by cAMP 2 antibody; Exchange protein directly activated by cAMP 2 antibody; Nbla00496 antibody; Putative protein product of Nbla00496 antibody; Rap guanine nucleotide exchange factor (GEF) 4 antibody; Rap guanine nucleotide exchange factor 4 antibody; RAPGEF 4 antibody; Rapgef4 antibody; RPGF4_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Rap guanine nucleotide exchange factor 4 protein (1-210AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
  • 基因功能參考文獻:
    1. Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production. PMID: 27649969
    2. rs17746510, one of the three single-nucleotide polymorphisms (SNPs) in RAPGEF4 associated with cognitive decline in Chinese Alzheimer's disease (AD) patients, was significantly correlated with apathy and mood disturbance PMID: 27598965
    3. Data show that Epac2 is activated by cAMP and changes its structure. It is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase and is expressed mainly in brain, neuroendocrine and endocrine tissues. [review] PMID: 26390815
    4. CALR regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF and PTGS2-mediated production of PGE2 through cAMP signaling. PMID: 25378661
    5. Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. PMID: 25187374
    6. EPAC2-mediated CRT expression is essential for the functional and morphological differentiation of endometrial stromal cells into decidual cells PMID: 24169561
    7. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry PMID: 21454623
    8. An important time-limited role is identified for hippocampal Epac2 signaling in cognition, opening new avenues to investigate the molecular mechanisms underlying memory retrieval. PMID: 19739231
    9. Epac2 & Epac1 signaling pathways may be associated with cAMP-mediated functional differentiation and syncytialization of trophoblasts. Expression of Epac2 & Epac 1 in placenta at different stages was investigated. PMID: 20663796
    10. Studies demonstrate the occurrence of the EPAC2 splicing variant EPAC2B in adrenocortical cancer cells and reveal the involvement of EPAC2B in cAMP-induced effects on cytoskeleton integrity and cell migration. PMID: 20233795
    11. Mutations in the hinge of Epac can uncouple cAMP binding from its exchange activity. PMID: 12469113
    12. variants were present in five families, where they segregate with the autistic phenotype. PMID: 14593429
    13. Epac2 signaling plays a stimulatory role in pancreatic and intestinal endocrine cells, including proglucagon transcription and glucagon and GLP-1 production. PMID: 18854429
    14. Substitution of the conserved phenylalanine 435 with glycine facilitates the hinge bending and leads to a constitutively active Epac2 capable of stimulating nucleotide exchange in the absence of cAMP. PMID: 19553663

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 組織特異性:
    Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
  • 數據庫鏈接:

    HGNC: 16626

    OMIM: 606058

    KEGG: hsa:11069

    STRING: 9606.ENSP00000380271

    UniGene: Hs.470646



主站蜘蛛池模板: 久久精品国产久精久精| 亚洲视频日本有码中文| 美女黄频视频大全免费的国内| 在线播放亚洲人成电影| 豆国产95在线 | 亚洲| 久久精品这里热有精品| 久久青青草原国产毛片| 韩国 日本 亚洲 国产 不卡| 免费人成视频19674不收费| 欧美国产激情18| 久久亚洲人成综合网| 99热网址最新获取域名| 北条麻妃在线一区二区| 日日拍夜夜嗷嗷叫国产| 丰满人妻熟妇乱又伦精品视 | 99久久无码一区人妻a片蜜| 夜夜添无码试看一区二区三区| 大屁股熟女一区二区三区| 精品黑人一区二区三区久久| 欧美孕妇变态孕交粗暴| 精品熟女少妇av久久免费软件| 肥臀熟女一区二区三区| 噜噜色综合噜噜色噜噜色| 日本天天日噜噜噜| 日亚韩在线无码一区二区三区| 无码中文字幕日韩专区视频| 国产极品白嫩精品| 东北老女人高潮大喊舒服死了 | 日韩中文字幕区一区有砖一区| 无码h肉在线观看免费一区| 国产精品鲁鲁鲁| 乱码人妻一区二区三区| 乌克兰少妇性做爰| 久久精品国产精品亚洲毛片| 日韩精品一区二区三区免费视频| 伊人久久大香线蕉午夜av| 校花高潮抽搐冒白浆| 隔壁人妻偷人bd中字| 又色又爽又黄的gif动态图| 亚洲国产成人久久综合一区77| 东京热无码av男人的天堂|