在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAP2B Antibody

RAP2B Antibody

  • 中文名稱：
    RAP2B兔多克隆抗體
  • 貨號：
    CSB-PA040161
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RAP2B
  • 別名：
    MGC20484 antibody; RAP 2B antibody; RAP2A antibody; Rap2b antibody; RAP2B member of RAS oncogene family antibody; RAP2B_HUMAN antibody; Ras family small GTP binding protein RAP2B antibody; Ras related protein RAP 2B antibody; Ras related protein RAP2B antibody; Ras-related protein Rap-2b antibody; Small GTP binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Rap 2B.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
  • 基因功能參考文獻：
    1. Rap2B was overexpressed in cervical cancer tissues and cell lines and knockdown of Rap2B inhibited cervical cancer cell proliferation, migration, and invasion in vitro and suppressed cervical cancer cell growth and metastasis in vivo PMID: 28390112
    2. these results revealed that Rap2B promotes renal cell carcinoma angiogenesis via phosphoinositide 3-kinase/AKT/vascular endothelial growth factor signaling pathway, which suggests that Rap2B is a novel therapeutic target for renal cell carcinoma anti-angiogenesis therapy. PMID: 28691643
    3. our results suggested that Rap2b may be a potential therapeutic target for lung cancer. PMID: 26671640
    4. knockdown of Rap2B inhibits the proliferation and invasion in HCC cells. These findings reveal that Rap2B plays an important role in the regulation of HCC progression. PMID: 28081729
    5. miR-194 is inversely correlated with RAP2B. PMID: 27133066
    6. Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK, suggesting that FAK-dependent pathway might be responsible for the effect of Rap2B on PCa cells migration and invasion. PMID: 27154636
    7. Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate PMID: 26308105
    8. Our collective findings provide preliminary evidence that miR-342-3p acts as a tumor suppressor in small cell lung cancer through repression of RAP2B. PMID: 25663460
    9. Rap2B itself is not necessary for p53-dependent cell cycle arrest. PMID: 25762091
    10. Data indicate that rap GTP-binding protein Rap2B expression is significantly increased in suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, suggesting a target for the treatment of suprarenal epithelioma. PMID: 24951956
    11. Rap2b is a conserved p53-activated gene that counters p53-mediated apoptosis after DNA damage. PMID: 23535297
    12. Rap2b mediates the pro-survival function of p53 upon DNA damage. PMID: 23535297
    13. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B PMID: 11877431
    14. the small GTPase Rap2B is involved in platelet activation PMID: 15613030
    15. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1. PMID: 17316888

    顯示更多

    收起更多

  • 亞細胞定位：
    Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 組織特異性：
    Expressed in red blood cells (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9862

    OMIM: 179541

    KEGG: hsa:5912

    STRING: 9606.ENSP00000319096

    UniGene: Hs.700713



主站蜘蛛池模板： 日韩精品电影综合区亚洲 | 中文在线а√在线天堂中文| 亚洲日韩欧美国产另类综合| 亚洲天天做日日做天天欢毛片 | 亚洲人成网站日本片| 无码人妻精品一区二区三区久久| 一区一区三区产品乱码| 国产麻豆精品一区| 熟女人妻av粗壮巨龙| 成人免费网站视频www| 少妇伦子伦精品无吗| 日本免费一区二区三区最新| 欧美村妇激情内射| 蜜桃麻豆www久久国产sex| 精人妻无码一区二区三区| 人妻aⅴ无码一区二区三区| 成人片无码免费播放| 人妻少妇88久久中文字幕| 久久人人爽人人爽人人片av东京热| 国产偷人妻精品一区二区在线| 巨熟乳波霸若妻在线播放| 双乳奶水饱满少妇呻吟| 欧美日韩在线第一页免费观看| 亚洲日韩av片在线观看| 亚洲不卡1卡2卡三卡入口| 亚洲精品无amm毛片| 野狼第一精品社区| 草裙社区精品视频三区免费看| 久久丫精品系列| 对白脏话肉麻粗话av| 青青草国产精品免费观看| 亚洲s久久久久一区二区| 色五月激情五月| 亚洲欧美日韩成人综合一区 | 日本精品中文字幕在线播放| 久久久久久好爽爽久久| 中文字幕人成乱码熟女| 欧美xxxx做受欧美1314| 国产精品亚洲a∨天堂| 青青草97国产精品免费观看| 男女同房做爰爽免费|