在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RALB Antibody

RALB Antibody

  • 中文名稱：
    RALB兔多克隆抗體
  • 貨號(hào)：
    CSB-PA219431
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA219431(RALB Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using CSB-PA219431(RALB Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse lung tissue, Primary antibody: CSB-PA219431(RALB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    5730472O18Rik antibody; dRalb antibody; GTP binding protein antibody; Ralb antibody; RALB_HUMAN antibody; RAS like protein B antibody; RAS like proto oncogene B antibody; Ras related GTP binding protein B antibody; Ras-related protein Ral-B antibody; v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody; v ral simian leukemia viral oncogene homolog B (ras related) antibody; V ral simian leukemia viral oncogene homolog B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human RALB
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:500-1:5000
    WB 1:500-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors.
  • 基因功能參考文獻(xiàn)：
    1. our work provides new insight into the specific roles of Ras effector pathways in acute myeloid leukemia and has identified RALB signaling as a key survival pathway PMID: 27556501
    2. High RALB expression is associated with acute myeloid leukemia. PMID: 27991934
    3. Inhibition of Ral GTPases Using a Stapled Peptide Approach. PMID: 27334922
    4. These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I. PMID: 25573158
    5. High RALB mRNA expression is associated with non-small-cell lung cancer growth and progression. PMID: 24389431
    6. Integrin alpha(v)beta expression and the resulting KRAS-RalB-NF-kappaB pathway were both necessary and sufficient for tumour initiation, anchorage independence, self-renewal and erlotinib resistance. PMID: 24747441
    7. nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles PMID: 24056301
    8. a novel RalB-mediated biochemical and signaling mechanism for invadopodium formation PMID: 22331470
    9. Study finds that the Ras-like small G protein, RalB, is localized to nascent autophagosomes and is activated on nutrient deprivation. PMID: 21241894
    10. Non-phosphorylated RalB is associated with bladder cancer cell growth and metastasis. PMID: 20940393
    11. RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival; RALB is specifically required for survival of tumour cells but not normal cells PMID: 12856001
    12. These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
    13. RalB was found to mediate SDF-1-induced migration PMID: 18227351
    14. Backbone dynamics and the structure of free RalB bound to the GTP analogue GMPPNP were determined using NMR spectroscopy. PMID: 19166349
    15. 1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation. Backbone amide dynamics parameters for a majority of residues have also been obtained PMID: 19636851

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9840

    OMIM: 179551

    KEGG: hsa:5899

    STRING: 9606.ENSP00000272519

    UniGene: Hs.469820



主站蜘蛛池模板： 麻豆视传媒官网免费观看| 免费1级a做爰片观看| 国产精自产拍在线看中文| 欧美精品一产区二产区| 欧美日本韩国亚洲| 内射中出日韩无国产剧情| 日产乱码一区二区三区在线| 亚洲国产区男人本色vr| 久久综合九色综合97欧美| 亚洲中文字幕无码一区在线| 18禁黄网站禁片无遮挡观看| 亚洲色成人一区二区三区| 成人免费无码大片a毛片| 另类老妇奶性生bbwbbw | 久久青草成人综合网站| 中国丰满少妇人妻xxx性董鑫洁| 国产suv精品一区| 中文乱码人妻系列一区| 成人无码av网站在线观看| 亚洲一区二区三区av天堂| 欧美性大战久久久久久| 久久久久无码精品国产人妻无码| 色欲香天天综合网站| 自拍偷自拍亚洲精品被多人伦好爽| 亚洲国产综合精品 在线 一区 | 国内少妇高潮嗷嗷叫在线播放| 国产成人免费一区二区三区| 狠狠色丁香久久婷婷综合图片 | 亚洲 欧美 日韩 国产综合 在线| 老妇高潮潮喷到猛进猛出| 99999久久久久久亚洲| 四虎av永久在线精品免费观看 | 国产精品无码永久免费不卡| 国色天香网www在线观看| 国产色a在线观看| 92久久精品一区二区| 国产精品久久国产精品99盘| 无码中文字幕av免费放dvd| 苍井空张开腿实干12次| 亚洲午夜久久久久妓女影院| 亚洲1卡二卡三新区2022|