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RAD9A Antibody

  • 中文名稱:
    RAD9A兔多克隆抗體
  • 貨號:
    CSB-PA019273GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cell cycle checkpoint control protein antibody; Cell cycle checkpoint control protein RAD9A antibody; DNA repair exonuclease rad9 homolog A antibody; hRAD 9 antibody; hRAD9 antibody; Rad 9 antibody; RAD 9A antibody; RAD9 (S pombe) homolog antibody; RAD9 homolog A antibody; RAD9 homolog antibody; Rad9a antibody; RAD9A_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RAD9A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
  • 基因功能參考文獻:
    1. The authors show that human Cyclin-Dependent-Kinases (CDKs) target the RAD9 subunit of the 9-1-1 checkpoint clamp on Thr292, to modulate DNA damage checkpoint activation. Thr292 phosphorylation on RAD9 creates a binding site for Polo-Like-Kinase1 (PLK1), which phosphorylates RAD9 on Thr313. PMID: 29254517
    2. TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint PMID: 26860083
    3. RAD9 has a prominent role in the ATR-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling. PMID: 26667770
    4. these results demonstrate a positive feedback loop involving Rad9A-dependend activation of Chk1. PMID: 26658951
    5. The role of Rad9 in homologous recombination is independent of its function in checkpoint activation, and this function is important for preventing alternative non-homologous end joining. PMID: 25485590
    6. we found that H1299 cells with reduced RAD9 protein levels showed a higher frequency of radiation induced bystander micronuclei formation PMID: 25234738
    7. These data reveal that human Rad9 interacts directly with N-terminal region of human MYH. PMID: 25127721
    8. Downregulation of RAD9 when combined with ionizing radiation results in reduction of ITGB1 protein levels in prostate cancer cells, and increased lethality. PMID: 25111005
    9. Loss of hrad9 expression is associated with breast and lung cancer. PMID: 24403312
    10. These data suggest that v-Src attenuates ATR-Chk1 signaling through the inhibition of Rad17-Rad9 interaction. PMID: 24971543
    11. Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit. PMID: 24376897
    12. Loss of Rad9 alters expression of nucleotide excision repair factors. PMID: 23433811
    13. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance. PMID: 23383325
    14. cyclin A-Cdk2 regulates apoptosis through a mechanism that involves Rad9phosphorylation PMID: 23028682
    15. Rad9 contributes to prostate tumorigenesis by increasing not only tumor proliferation and survival but also tumor migration and invasion, anoikis resistance, and anchorage-independent growth PMID: 23066031
    16. the affinity of Rad9 to TopBP1 correlates with the activation of the cellular DNA damage response and survival after DNA damage in HeLa cells. PMID: 22925454
    17. A review of the many activities assigned to Rad9, and speculation as to which influence its function in tumor development. PMID: 22034047
    18. The RAD9 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins. PMID: 21978893
    19. Data indicate that association of RAD18 with DSBs through ubiquitylated H2A and other ubiquitylated chromatin components allows recruitment of RAD9. PMID: 21858012
    20. Modulation of RAD9A and other cell cycle arrest and DNA repair proteins contribute to the risk of developing a second malignancy in childhood cancer patients. PMID: 21991345
    21. When over-expressed in HeLa cells, a mutant Rad9 harboring phospho-deficient substitutions at both Ser-341 and Ser-387 residues causes hypersensitivity to UV and methyl methane sulfonate. PMID: 20545769
    22. results emphasize the importance of Rad9A in preserving genomic integrity in the presence of catenated chromosomes and all types of DNA aberrations PMID: 20305300
    23. Rad9A-mediated Claspin localization is a vital step during checkpoint activation. PMID: 20081369
    24. These findings indicate that Rad9 is regulated by a c-Abl-dependent mechanism in the apoptotic response to genotoxic stress. (c-abl protein) PMID: 11971963
    25. role of C-terminal region in nuclear transport of the hRad9 checkpoint complex PMID: 11994305
    26. Protein kinase C-delta is responsible for constitutive and DNA damage-induced phosphorylation of this protein. PMID: 12628935
    27. the Rad9 phospho-tail is a key participant in the transduction of downstream checkpoint signals PMID: 12709442
    28. Characterization of nonphosphorylatable mutants has revealed that Rad9 phosphorylation plays a critical role in checkpoint signaling. PMID: 12734188
    29. hRad9/hHus1/hRad1 complex acts as a checkpoint sensor during S phase by rapidly localizing to sites of DNA damage and transducing checkpoint responses by facilitating proper localization of downstream checkpoint proteins, including TopBP1. PMID: 12941802
    30. HRAD9 and Mrad9 are part of a gene family and reveal a new genetic element encoding a product that interacts with multiple, known cell cycle checkpoint control proteins. PMID: 14500360
    31. Data report the identification of Rad9, a key member of the checkpoint Rad protein family, as a coregulator to suppress androgen-androgen receptor transactivation in prostate cancer cells. PMID: 14966297
    32. results suggest that the predominant role of Rad9 in embryonic stem cells is to promote survival after replicative stress and topoisomerase-mediated DNA damage PMID: 14988409
    33. Rad9 stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. PMID: 15326225
    34. complex with rad1 and hus1 is a damage-specific activator of flap endonuclease 1 PMID: 15556996
    35. Rad9 expression may play an important role in cell cycle control in NSCLC cells and may influence NSCLC cell phenotype PMID: 15558813
    36. Rad9 plays critical role in the activation of S-phase checkpoint and the maintenance of chromosome stability. PMID: 15773892
    37. The encoded mammalian proteins participate in promoting resistance to DNA damage, cell cycle checkpoint control, DNA repair, and apoptosis. PMID: 16365875
    38. role for Rad9 in telomere stability and homologous recombinational repair as a mechanism for promoting cell survival after ionizing radiation exposure PMID: 16479004
    39. Human NEIL1 DNA glycosylase activity is significantly stimulated by hRad9 and by the Rad9/Rad1/Hus1 heterotrimer. PMID: 17395641
    40. Rad9 modulates the P21WAF1 pathway by direct association with p53. PMID: 17511890
    41. Rad9 expression correlated closely to significance only with the apoptotic and mitotic indices in epithelial ovarian tumors PMID: 18156970
    42. elements found in the aquaporin-5 and the Rad9 (radiation-sensitive 9) genes showed selective AR versus GR binding in band-shift assays and a strong activity and selectivity in functional assays, both as isolated elements and in their original contexts PMID: 18215141
    43. Rad9 levels are high in prostate cancer cells due at least in part to aberrant methylation or gene amplification PMID: 18316588
    44. up-regulated in breast cancer; mRNA up-regulation correlates with tumor size and local recurrenc;hyperphosphorylated forms of the protein inthe nucleus of the cancer cells PMID: 18616832
    45. Disruption of the Rad9-MLH1 interaction by a single-point mutation in Rad9 leads to significantly reduced DNA mismatch repair activity. PMID: 18842633
    46. Data show that the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling. PMID: 18936170
    47. Rad9 foci were predominately formed in G1 and S phase after UV light, while treatment of cells with ionizing radiation (IR) resulted in accumulation of Rad9 into foci in S and G2. PMID: 19411845

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Rad9 family
  • 數據庫鏈接:

    HGNC: 9827

    OMIM: 603761

    KEGG: hsa:5883

    STRING: 9606.ENSP00000311360

    UniGene: Hs.655354



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