在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAD51D Antibody

RAD51D Antibody

  • 中文名稱：
    RAD51D兔多克隆抗體
  • 貨號：
    CSB-PA019268ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: DNA repair protein RAD51 homolog 4 antibody at 8μg/ml + Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 36, 6, 24, 31, 13, 23, 38 kDa
      Observed band size: 36 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA019268ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RAD51D Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RAD51D
  • 別名：
    BROVCA4 antibody; DNA repair protein RAD51 homolog 4 antibody; HsTRAD antibody; OTTHUMP00000163851 antibody; OTTHUMP00000163852 antibody; OTTHUMP00000163853 antibody; R51H3 antibody; RA51D_HUMAN antibody; RAD51 homolog D (S. cerevisiae) antibody; RAD51 homolog D antibody; RAD51 like 3 (S. cerevisiae) antibody; RAD51 paralog D antibody; RAD51, S. cerevisiae, homolog of, D antibody; RAD51-like protein 3 antibody; Rad51l3 antibody; Recombination repair protein antibody; S. cerevisiae RAD51-like 3 antibody; TRAD antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DNA repair protein RAD51 homolog 4 protein (1-328AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
  • 基因功能參考文獻：
    1. Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece. PMID: 30111881
    2. Results highlight the importance of a functional RAD51D-XRCC2 interaction to promote HR and prevent the development of HGSC. PMID: 28646019
    3. variants in RAD51D were associated with moderate risks of breast cancer. PMID: 28418444
    4. of Rad51d mediated by E3 Ligase Rnf138 has a role in the homologous recombination repair pathway PMID: 27195665
    5. endogenous regulation of RAD51D by miR-103/107 was observed in several tumor subtypes; both miR-103 and miR-107 directly target and regulate RAD51 and RAD51D PMID: 24088786
    6. We aimed to determine the prevalence of germline RAD51D mutations in Spanish breast and ovarian cancer families negative for BRCA1/BRCA2 PMID: 24130102
    7. Our data provide additional evidence that RAD51D mutations are enriched among ovarian cancer patients, but are extremely rare among familial breast cancer patients. PMID: 23372765
    8. loss-of-function mutations in RAD51D predispose to ovarian carcinoma but not to breast carcinoma. PMID: 22986143
    9. RAD51D is primarily a moderate penetrance susceptibility gene for ovarian cancer, with clinical significance for the carriers. PMID: 22652533
    10. The RAD51D should be included in genetic screening of ovarian cancer families that do not have BRCA1/BRCA2 mutations. PMID: 22415235
    11. These data indicate that RAD51D mutation testing may have clinical utility in individuals with ovarian cancer and their families. PMID: 21822267
    12. The N-terminal domain of Rad51D is required for the ssDNA-specific binding function of human Rad51D. PMID: 21111057
    13. Polymorphisms in RAD51D gene is associated with breast cancer. PMID: 20054644
    14. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex PMID: 11834724
    15. RAD51L3 cooperates with Bloom Syndrome Protein during the late stages of homologous recombination processes that serve to restore productive DNA replication at sites of damaged or stalled replication forks PMID: 12975363
    16. Telomere maintenance requires RAD51D. PMID: 15109494
    17. E233G single nucleotide polymorphism is a low-penetrance susceptibility gene in the specific subgroup of high-risk familial breast cancer cases that are not related to BRCA1/2. PMID: 15170666
    18. Interactions between RAD51D and its XRCC2 and RAD51C partners require a functional RAD51D Walker B ATPase motif, but not motif A. PMID: 16717288
    19. The RAD51D E233G variant is not associated with breast cancer. PMID: 18058226

    顯示更多

    收起更多

  • 相關疾病：
    Breast-ovarian cancer, familial, 4 (BROVCA4)
  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.
  • 蛋白家族：
    RecA family, RAD51 subfamily
  • 組織特異性：
    Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes.
  • 數據庫鏈接：

    HGNC: 9823

    OMIM: 602954

    KEGG: hsa:5892

    STRING: 9606.ENSP00000466834

    UniGene: Hs.631757



主站蜘蛛池模板： 国产精品人人爽人人做我的可爱| 久久精品国产亚洲不av麻豆 | 99re6这里有精品热视频| 色爱无码av综合区| 国产av激情久久无码天堂| 国产av亚洲aⅴ一区二区| 中国老妇xxxx性开放| 欧美老妇乱辈通奷| 欧洲lv尺码大精品久久久| 99国产精品自在自在久久| 日日躁狠狠躁狠狠爱| 国产片av国语在线观麻豆| 一区二区三区内射美女毛片| 亚洲精品成人片在线观看精品字幕| 青青青草国产线观| 色综合亚洲一区二区小说性色aⅴ 最激烈的床震娇喘视频出水 | 2021国产精品视频网站| 国产亚洲曝欧美曝妖精品| 丰满人妻精品国产99aⅴ| 久久精品无码一区二区三区| 国产av一区二区精品凹凸| 一区二区三区在线 | 日| 熟妇人妻系列aⅴ无码专区友真希| 久久人妻无码中文字幕| 日本一区二区三区免费播放视频站| 国产成人精品无码a区在线观看| 人妻少妇精品视频二区| 丰满少妇被粗大的猛烈进出视频| 午夜无码精品国产片| 久久一日本综合色鬼综合色| 久久天天躁狠狠躁夜夜avapp| 久久九九精品99国产精品| 在线|国产精品女主播阳台| 内射老阿姨1区2区3区4区| 波多野结衣一区二区三区高清av| 伊人色综合久久天天网| 自拍偷在线精品自拍偷免费| 亚洲日本va中文字幕| 人人爽人人爽人人片a| 亚洲欧洲综合有码无码| 国产午夜手机精彩视频|