在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RAD51AP1 Antibody

RAD51AP1 Antibody

  • 中文名稱：
    RAD51AP1兔多克隆抗體
  • 貨號：
    CSB-PA019264GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    RAD51AP1
  • 別名：
    2510006L10Rik antibody; MGC156698 antibody; OTTMUSP00000028651 antibody; PIR51 antibody; R51A1_HUMAN antibody; RAB22 antibody; RAD51 associated protein 1 antibody; RAD51 interacting protein antibody; RAD51-associated protein 1 antibody; RAD51-interacting protein antibody; Rad51ap1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human RAD51AP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination. Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51. Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation. Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair. WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2. Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination. Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination. May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo.
  • 基因功能參考文獻：
    1. RAD51AP1 upregulation is described in both tissue and matching blood from patients with ovarian and lung cancer compared with healthy controls. PMID: 29126163
    2. The current understanding of the biochemical and biological functions of RAD51AP1 as HR factor is reviewed. It is also discussed how RAD51AP1 may help to promote cancer development and potentially be a promising new target for therapeutic intervention. [REVIEW] PMID: 28963981
    3. USP1-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1. PMID: 27463890
    4. RAD51AP1 is required for the maintenance of DNA replication fork progression. PMID: 25288561
    5. Data suggest that microRNA/mRNA pairs in hsa-miR-140-3p/RAD51AP1/, hsa-miR-145/E2F3, hsa-miR-139-5p/TOP2A, and hsa-miR-133a/GCLC were correlated with ovarian tumorigenesis. PMID: 22452920
    6. We have finely mapped the two DNA binding domains in RAD51AP1 and using mutant variants, reveal that both domains are indispensable for RAD51AP1 function in cells. PMID: 22375013
    7. RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif. PMID: 21903585
    8. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes. PMID: 21307306
    9. Although PALB2 alone stimulates D-loop formation, it has a cooperative effect with RAD51AP1, an enhancer of RAD51. PMID: 20871616
    10. expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues PMID: 14966907
    11. RAD51AP1 has a selective affinity for branched-DNA structures that are obligatory intermediates during joint molecule formation. PMID: 17996710
    12. RAD51AP1 helps maintain genomic integrity via RAD51 recombinase enhancement. PMID: 17996711
    13. Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma PMID: 18316552

    顯示更多

    收起更多

  • 亞細胞定位：
    Chromosome. Nucleus. Chromosome, telomere.
  • 組織特異性：
    Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 16956

    OMIM: 603070

    KEGG: hsa:10635

    STRING: 9606.ENSP00000228843

    UniGene: Hs.730696



主站蜘蛛池模板： 欧洲丰满大乳人妻无码欧美| 国产99在线 | 中国| 欧美激性欧美激情在线| 免费的污污的网站在线观看| 国产sm重味一区二区三区| 国产成人免费无码视频在线观看 | 精品人妻大屁股白浆无码| 亚洲色大18成人网站www在线播放| 丁香婷婷无码不卡在线| 色哟哟免费视频播放网站| 一卡二卡3卡四卡网站精品| 亚洲 欧美 激情 小说 另类| 无罩大乳的熟妇正在播放| 久久人妻无码中文字幕| 狼群社区www中文视频| 免费大片av手机看片不卡| 国产又粗又猛又爽又黄的视频在线观看动漫| 欧美成人午夜精品久久久| 国产精品久久精品国产| 亚洲va综合va国产产va中文| 午夜免费无码福利视频| 国产成人啪精品午夜网站a片免费| 深夜福利在线观看视频| 亚洲精品久久久久久动漫器材一区 | 在线视频夫妻内射| 麻豆视传媒精品av| 亚洲精品久久国产高清小说| 欧美熟妇色ⅹxxx欧美妇| 无套内射在线无码播放| 久久精品女人天堂av麻| 四虎永久在线精品884aa| 美女18禁一区二区三区视频| 亚洲精华国产精华精华液网站| 狠狠五月深爱婷婷网| 欧美人与动牲交app视频| 国产精品免费无码二区| 伦人伦xxx国产对白| 日韩精品无码免费专区网站| 99亚洲精品自拍av成人| 人妻夜夜添夜夜无码av| 久久久久人妻精品一区蜜桃|