在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RAD1 Antibody

  • 中文名稱:
    RAD1兔多克隆抗體
  • 貨號:
    CSB-PA019252GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cell cycle checkpoint protein Hrad1 antibody; Cell cycle checkpoint protein Rad 1 A / B antibody; Cell cycle checkpoint protein RAD1 antibody; Checkpoint control protein HRAD1 antibody; Checkpoint control protein RAD1 antibody; DNA repair exonuclease antibody; DNA repair exonuclease rad1 antibody; DNA repair exonuclease rad1 homolog antibody; DNA repair exonuclease REC1 antibody; DNA repair protein RAD1 antibody; EC 3.1.11.2 antibody; Exonuclease homolog RAD1 antibody; GTP-binding protein RAD antibody; hRAD 1 antibody; hRAD1 antibody; MGC77779 antibody; RAD 1 antibody; RAD antibody; RAD1 antibody; RAD1 homolog (S. pombe) antibody; RAD1 homolog antibody; Rad1 like DNA damage checkpoint antibody; Rad1 like DNA damage checkpoint protein antibody; RAD1; S. pombe; homolog of antibody; Rad1-like DNA damage checkpoint protein antibody; RAD1_HUMAN antibody; Ras associated with diabetes antibody; REC 1 antibody; REC1 antibody; RRAD antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human RAD1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.
  • 基因功能參考文獻:
    1. Dominant alleles of RAD51, TP53 and XRCC1 combined genotypes indicated a strong protective role against hereditary breast cancer. PMID: 26954070
    2. Intramolecular binding of the rad9 C-terminus in the checkpoint clamp Rad9-Hus1-Rad1 is closely linked with its DNA binding. PMID: 26088138
    3. Data show models for the ternary PCNA/FEN1/DNA and Rad9-Rad1-Hus1 (9-1-1 complex)/FEN1/DNA assemblies. PMID: 22586102
    4. The RAD1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins. PMID: 21978893
    5. CK2 plays a crucial role in the ATR-dependent checkpoint pathway through its ability to phosphorylate Ser-341 and Ser-387 of the Rad9 subunit of the Rad9-Hus1-Rad1 complex PMID: 20545769
    6. 9-1-1 complex is a component of the mismatch repair involved in MNNG-induced damage response. PMID: 20188637
    7. Rad9-Rad1-Hus1 complex enhances in vitro activity of 8-oxoguanine DNA glycosylase. PMID: 19615952
    8. Rad9, Hus1, and Rad1 heterotrimeric complex chromatin binding is a proximal event in the checkpoint signaling cascade PMID: 12228248
    9. RAD1 is a potential intrinsic chaperone in the stabilization of HUS1 for the heterotrimeric (RAD9-RAD1-HUS1) checkpoint complex formation. PMID: 15122316
    10. The human Rad9/Rad1/Hus1 complex interacts with and stimulates DNA polymerase beta activity. PMID: 15314187
    11. complex with rad9 and hus1 is a damage-specific activator of flap endonuclease 1 PMID: 15556996
    12. The long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA. PMID: 15871698
    13. PCNA and the Rad9/Rad1/Hus1 complex can independently bind and activate Fen1; acetylation of Fen1 by p300-HAT abolished the stimulatory effect of the complex but not that of PCNA, suggesting a possible mechanism of regulation of this repair pathway PMID: 16216273
    14. human DNA ligase I is stimulated by the Rad9-rad1-Hus1 checkpoint complex PMID: 16731526
    15. These data provide in vivo evidence that the human 9-1-1 complex participates in DNA repair in addition to its previously described role in DNA damage sensing. PMID: 16814252
    16. Human NEIL1 DNA glycosylase activity is significantly stimulated by hRad1 and by the Rad9/Rad1/Hus1 heterotrimer. PMID: 17395641
    17. we report successful tri-cistronic cloning, overexpression and purification of a three-protein complex of Rad9, Rad1 and Hus1 using a single hexa-histidine tag. PMID: 17493829
    18. Jab1 physically associates with the 9-1-1 complex; this association is mediated through direct interaction between Jab1 and Rad1, one of the subunits of the 9-1-1 complex PMID: 17583730
    19. Human thymine DNA glycosylase activity is significantly stimulated by hHus1, hRad1, hRad9 separately, and by the 9-1-1 complex. PMID: 17855402
    20. The DNA binding domain (DBD) within the hLigI catalytic fragment interacts with both PCNA and the heterotrimeric cell-cycle checkpoint clamp, hRad9-hRad1-hHus1 (9-1-1). PMID: 19523882
    21. The interdomain connecting loops (IDC loop) of hRad9, hHus1, and hRad1 are largely divergent and unique structural features of the 9-1-1 complex that are proposed to contribute to DNA damage recognition. PMID: 19535328

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Rad1 family
  • 組織特異性:
    Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).
  • 數據庫鏈接:

    HGNC: 9806

    OMIM: 603153

    KEGG: hsa:5810

    STRING: 9606.ENSP00000340879

    UniGene: Hs.38114



主站蜘蛛池模板: 久久久一本精品99久久精品66直播| 高清一区二区三区日本久| 亚洲国产成人综合一区二区三区| 3d动漫精品啪啪一区二区免费| 中文乱码人妻系列一区二区| 中文字幕无码人妻丝袜| 69久久精品无码一区二区无码| 亚洲国产精品一区二区www| 婷婷五月综合色视频| 久久视频这里有精品33| a欧美爰片久久毛片a片| 少妇精品无码一区二区免费视频| 国产免费视频| 国产高清午夜人成在线观看| 少妇呻吟白浆高潮啪啪69| 国产人妻大战黑人20p| 国产97色在线 | 日韩| 国产成人综合久久精品推最新| 无码精品人妻一区二区三区av| 国产成人精品一区二区三区| 国产老熟女网站| 制服 丝袜 亚洲 中文 综合| 久久精品www人人做人人爽| 邻居少妇张开腿让我爽了在线观看| 欧美交换配乱吟粗大25p | 偷窥 亚洲 另类 图片 熟女| 午夜影视免费x看| 五月av综合av国产av| 日本午夜免费啪视频在线| 国产区精品一区二区不卡中文 | 欧美牲交a欧美牲交aⅴ久久| 国精品无码一区二区三区在线| 99国产成人精品视频| 国产国拍精品av在线观看按摩| 国产成人久久精品一区二区三区 | 欧美乱码卡一卡二卡三新区| 四川丰满妇女毛片四川话| 国产人成无码视频在线| 亚洲精品第一国产综合国服瑶 | 国产麻豆精品福利在线观看 | 亚洲色大成网站www永久网站|